Transitioning From Bimodal to Bilateral Cochlear Implant Listening: Speech Recognition and Localization in Four Individuals

Potts, Lisa G.; Litovsky, Ruth Y.

doi:10.1044/1059-0889(2013/11-0031)

Cited by 30 publications

(26 citation statements)

References 53 publications

(88 reference statements)

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“…For example, if a person uses a CI and a contralateral hearing aid and there is minimal contribution of the hearing aid to the binaural score, bilateral CIs could be the next step. Indeed, studies conducted by Ching et al (2007) and Potts and Litovsky (2014) have reported on these client outcomes comparing bimodal to bilateral CI use, with encouraging results.…”

Section: Discussionmentioning

confidence: 95%

“…For these reasons, bimodal users may be at a further disadvantage compared to bilateral CI users on sound localization tasks. Studies comparing sound localization ability across these modes within a given individual have shown that bilateral CI use provides improved sound localization and better subjective outcomes compared to bimodal use for adult listeners (Ching et al, 2007; Potts & Litovsky, 2014), suggesting that, at least for some individuals, bilateral CI use may provide better spatial hearing ability than bimodal use.…”

Section: Discussionmentioning

confidence: 99%

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Self-Reported Spatial Hearing Abilities Across Different Cochlear Implant Profiles

Perreau

Tyler

et al. 2014

Am J Audiol

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Purpose The goal of this study was to determine how self-reported spatial hearing abilities differ across various cochlear implant (CI) profiles and to examine the degree of subjective benefit following cochlear implantation across different groups of CI users. Method This was a retrospective study of subjective spatial hearing ability of CI recipients. The subjects consisted of 99 unilateral CI users, 49 bilateral CI users, 32 subjects with a CI and contralateral hearing aid (bimodal users), and 37 short-electrode CI users. All subjects completed the Spatial Hearing Questionnaire (Tyler, Perreau, & Ji, 2009), a questionnaire assessing spatial hearing ability, after implantation, and a subset of the subjects completed the questionnaire pre- and postimplantation. Results Subjective spatial hearing ability was rated higher for the bilateral and short electrode CI users compared to the unilateral and bimodal users. There was no significant difference in subjective spatial hearing performance between the bilateral and short electrode CI users and the unilateral CI and bimodal users. A separate analysis of pre- and postimplant performance revealed that all CI groups reported significant improvements in spatial hearing ability after implantation. Conclusion This study suggests that there are substantial differences in perceived spatial hearing ability among unilateral and bimodal CI users compared with bilateral and short electrode CI users.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Self-Reported Spatial Hearing Abilities Across Different Cochlear Implant Profiles

Perreau

Tyler

et al. 2014

Am J Audiol

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“…Indeed, deaf patients wearing bilateral cochlear implants can detect ILDs (Nopp et al . ; van Hoesel, ; Seeber & Fastl, ; Potts & Litovsky, ).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, OTOF patients with cochlear implants might be able to process ILDs efficiently. Indeed, deaf patients wearing bilateral cochlear implants can detect ILDs (Nopp et al 2004;van Hoesel, 2004;Seeber & Fastl, 2008;Potts & Litovsky, 2014).…”

Section: Discussionmentioning

confidence: 99%

Topographic map refinement and synaptic strengthening of a sound localization circuit require spontaneous peripheral activity

Müller

Sonntag

Maraslioglu

et al. 2019

The Journal of Physiology

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Key points Loss of the calcium sensor otoferlin disrupts neurotransmission from inner hair cells. Central auditory nuclei are functionally denervated in otoferlin knockout mice (Otof KOs) via gene ablation confined to the periphery. We employed juvenile and young adult Otof KO mice (postnatal days (P)10–12 and P27–49) as a model for lacking spontaneous activity and deafness, respectively. We studied the impact of peripheral activity on synaptic refinement in the sound localization circuit from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO). MNTB in vivo recordings demonstrated drastically reduced spontaneous spiking and deafness in Otof KOs. Juvenile KOs showed impaired synapse elimination and strengthening, manifested by broader MNTB–LSO inputs, imprecise MNTB–LSO topography and weaker MNTB–LSO fibres. The impairments persisted into young adulthood. Further functional refinement after hearing onset was undetected in young adult wild‐types. Collectively, activity deprivation confined to peripheral protein loss impairs functional MNTB–LSO refinement during a critical prehearing period. Abstract Circuit refinement is critical for the developing sound localization pathways in the auditory brainstem. In prehearing mice (hearing onset around postnatal day (P)12), spontaneous activity propagates from the periphery to central auditory nuclei. At the glycinergic projection from the medial nucleus of the trapezoid body (MNTB) to the lateral superior olive (LSO) of neonatal mice, super‐numerous MNTB fibres innervate a given LSO neuron. Between P4 and P9, MNTB fibres are functionally eliminated, whereas the remaining fibres are strengthened. Little is known about MNTB–LSO circuit refinement after P20. Moreover, MNTB–LSO refinement upon activity deprivation confined to the periphery is largely unexplored. This leaves a considerable knowledge gap, as deprivation often occurs in patients with congenital deafness, e.g. upon mutations in the otoferlin gene (OTOF). Here, we analysed juvenile (P10–12) and young adult (P27–49) otoferlin knockout (Otof KO) mice with respect to MNTB–LSO refinement. MNTB in vivo recordings revealed drastically reduced spontaneous activity and deafness in knockouts (KOs), confirming deprivation. As RNA sequencing revealed Otof absence in the MNTB and LSO of wild‐types, Otof loss in KOs is specific to the periphery. Functional denervation impaired MNTB–LSO synapse elimination and strengthening, which was assessed by glutamate uncaging and electrical stimulation. Impaired elimination led to imprecise MNTB–LSO topography. Impaired strengthening was associated with lower quantal content per MNTB fibre. In young adult KOs, the MNTB–LSO circuit remained unrefined. Further functional refinement after P12 appeared absent in wild‐types. Collectively, we provide novel insights into functional MNTB–LSO circuit maturation governed by a cochlea‐specific protein. The central malfunctions in Otof KOs may have implications for patients with sensorineuronal hearing loss.

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“…Potts and Litovksy 13 describe speech understanding and sound source localization for four individuals in bimodal and bilateral CI conditions. The individuals received little benefit from amplification in the bimodal condition, as scores were no different than the unilateral CI condition.…”

Section: Introductionmentioning

confidence: 99%

A Within-Subject Comparison of Bimodal Hearing, Bilateral Cochlear Implantation, and Bilateral Cochlear Implantation With Bilateral Hearing Preservation

Gifford¹,

Driscoll²,

Davis³

et al. 2015

Otology &Amp; Neurotology

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A comparison of bimodal hearing and bilateral cochlear implants (CIs) was completed using a within-subjects, repeated-measures study for eight adult sequential recipients who despite achieving incredibly high performance with the first CI, self-selected for bilateral implantation. Speech understanding was assessed with the minimum speech test battery (MSTB) as well as sentences in semi-diffuse noise using the R-SPACE™ system. Conditions included unilateral hearing aid (HA) in the non-implanted ear, unilateral CI, bimodal (CI+HA), and bilateral CI. Additionally, three participants had bilateral hearing preservation and were also tested with bilateral CIs and bilateral HAs (BiBi). All testing was completed in the bimodal hearing configuration and repeated at least six months following activation of the second CI. Bilateral CIs afforded significant individual improvement in a complex listening environment even for individuals demonstrating near perfect sentence scores with both the 1st CI alone as well as the bimodal condition. The 3 BiBi participants demonstrated additional significant benefit over the bilateral CI condition—presumably due to the availability of interaural time difference cues. These data suggest that for noisy environments, adding a second implant can significantly improve speech understanding—even for high performing unilateral CI with bimodal hearing. In diffuse noise conditions, bilateral acoustic hearing can yield even greater benefit beyond that offered by bilateral implantation.

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Transitioning From Bimodal to Bilateral Cochlear Implant Listening: Speech Recognition and Localization in Four Individuals

Cited by 30 publications

References 53 publications

Self-Reported Spatial Hearing Abilities Across Different Cochlear Implant Profiles

Self-Reported Spatial Hearing Abilities Across Different Cochlear Implant Profiles

Topographic map refinement and synaptic strengthening of a sound localization circuit require spontaneous peripheral activity

A Within-Subject Comparison of Bimodal Hearing, Bilateral Cochlear Implantation, and Bilateral Cochlear Implantation With Bilateral Hearing Preservation

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