Sense of Coherence (SOC) is conceptualized as promoting resistance to stress. The study aimed to assess the impact of the Big Five personality traits and Social Capital (SC) on SOC levels during COVID-19, comparing associations with the pre-pandemic period. Another aim was to explore how personality and SC relate differently to SOC domains: Comprehensibility, Manageability, and Meaningfulness, reflecting perceptions of order, resource adequacy, and life’s significance, respectively. SOC, Big Five personality traits, SC (using by the 13 items SOC scale, NEO-FFI and PSCS inventories, respectively) and demographic data were obtained from 2717 Israeli participants during the heights of the third COVID-19 wave (November 2020–March 2021). Strong relationships between SOC and personality traits have been found through regression analysis, but these associations differed between SOC domains. Big Five traits demonstrated comparable association with Comprehensibly and Manageability, but different from those with Meaningfulness, particularly in Neuroticism, Openness and Extraversion. Significant SC–SOC associations were observed, though weaker than those reported in the pre-pandemic period. Age and female sex were also associated with stronger SOC. Overall, effect sizes for SOC domains were medium to large for Big Five personality traits and small to medium for demographic variables. SC demonstrated a negligible effect size. Significant interactions of demographic, SC and personality traits were also observed. The study highlights SOC’s strong links with personality and demographics, but weaker ties with psychosocial factors. Variations across SOC domains may explain diverse crisis effects.