[Translated article] ANTES Program: One Year on

Agustí, Àlvar; Alcázar, Bernardino; Ancochea, Julio; Casanova, Ciro; Celli, Bartolomé R.; Cosío, Borja G.; Echave-Sustaeta, José; Villar, Alberto Fernández; Rivero, Juan Luis García; González, Cruz; Izquierdo, José Luis; Lόpez-Campos, José Luís; Trigo, José María Marín; Sánchez, Javier Martín; Miravitlles, Marc; Molina, Jesús; Peces-Barba, Germán; Román, Miguel; Cataluña, Juan José Soler; Villar-Álvarez, Felipe

doi:10.1016/j.arbres.2021.10.011

Cited by 2 publications

(5 citation statements)

References 18 publications

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“…However, some researchers argue that spirometry may underestimate existing physiological damage. Accordingly, other diagnostic methods are advocated, such as measuring the diffusing capacity for carbon monoxide (DLCO) [ 10 ], structural abnormalities detected in computed tomography (CT) [ 33 ], such as the thickening of the wall of segmental and subsegmental bronchi or emphysema [ 34 ], or even detecting dysfunction of the small airway through techniques such as impulse oscillometry [ 35 ].…”

Section: Mild Copdmentioning

confidence: 99%

“…Second, it is a group of patients with a high impact of the disease. Notably, the available evidence shows that young patients are not asymptomatic; instead, they have a higher symptom burden, worse HRQoL, and considerably more exacerbations than older COPD subjects [ 10 ]. Additionally, there is also evidence that COPD subjects under the age of 50 years old have a more accelerated FEV 1 loss [ 11 , 14 ].…”

Section: Young Copdmentioning

confidence: 99%

“…In this sense, a working group in Spain has begun to assess an ambitious and multicenter research initiative named ANTES (anticipating the diagnosis and treatment of COPD in the 21st century) [ 9 , 10 , 88 ]. This initiative is based on the hypothesis that anticipating the diagnosis and treatment of COPD will lead to reducing the impact of the disease, improving its prevention, its treatment and its prognosis.…”

Section: Future Directionsmentioning

confidence: 99%

“…One of these initiatives is to establish a protocol which allows us to identify the disease in its earliest stages [ 9 ]. The hypothesis behind this is that it would be possible to improve prognosis and change the natural history of the disease at these stages [ 10 ]. This proposal has a solid background for several reasons.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD

Doña

Reinoso-Arija

Carrasco‐Hernández

et al. 2023

JCM

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The need to improve health outcomes, as well as disease prognosis, has led clinicians and researchers to propose new ways of identifying COPD in its earliest forms. This initiative is based on the hypothesis that an earlier intervention would have a greater prognostic impact. However, the operational definition of a patient in the initial stages of the disease is complex, and there is still no unanimously accepted definition. GOLD has recently proposed different concepts to identify COPD in its early stages, such as COPD in young people or COPD with mild functional impairment. In addition, GOLD proposes two other concepts, called pre-COPD (symptomatic non-obstructive patients) and PRISm (preserved ratio with impaired spirometry), which aim to identify the patient at risk of developing this chronic airflow obstruction. However, despite the attractiveness of these concepts, none have been taken up universally by the medical community. A universally accepted identification of how to define COPD in its early stages is necessary as a preliminary step in order to design clinical trials to find out the best way to treat these patients. This review deals with these concepts of COPD at the onset of the disease, highlighting their importance and the problems involved in identifying them as therapeutic targets in real clinical practice.

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Section: Mild Copdmentioning

confidence: 99%

Section: Young Copdmentioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD

Doña

Reinoso-Arija

Carrasco‐Hernández

et al. 2023

JCM

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“…No se conoce la evolución/pronóstico de este subgrupo de sujetos ni su tratamiento específico. El programa ANTES, liderado por investigadores españoles, pretende aclarar esta cuestión, entre otras 33 .…”

Section: Highlights En El áRea De Enfermedad Pulmonar Obstru...unclassified

Highlights del 55.° Congreso SEPAR

Meñaca

Herranz

Muñoz-Esquerre

et al. 2023

Open Respiratory Archives

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[Translated article] ANTES Program: One Year on

Cited by 2 publications

References 18 publications

Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD

Exploring Current Concepts and Challenges in the Identification and Management of Early-Stage COPD

Highlights del 55.° Congreso SEPAR

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