[Translated article] Biological Biomarkers in Respiratory Diseases

García‐Río, Francisco; Alcázar‐Navarrete, Bernardino; Castillo-Villegas, Diego; Cillóniz, Catia; García-Ortega, Alberto; Leiro-Fernández, Virginia; Lojo-Rodríguez, Irene; Padilla-Galo, Alicia; Quezada-Loaiza, Carlos A.; Rodríguez-Portal, José Antonio; Sánchez‐de‐la‐Torre, Manuel; Sibila, Oriol; Martínez‐García, Miguel Ángel

doi:10.1016/j.arbres.2022.01.010

Cited by 18 publications

(6 citation statements)

References 183 publications

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“…Respiratory diseases are the diseases affecting the organs and tissues involved in gas exchange in air-breathing animals [ 46 ]. Some of the most common respiratory diseases include obstructive lung disease, restrictive lung disease, and respiratory tract infections.…”

Section: Resultsmentioning

confidence: 99%

The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various Diseases

2022

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Background. Although transcriptomic data have been widely applied to explore various diseases, few studies have investigated the association between transcriptomic perturbations and disease development in a wide variety of diseases. Methods. Based on a previously developed algorithm for quantifying intratumor heterogeneity at the transcriptomic level, we defined the variation of transcriptomic perturbations (VTP) of a disease relative to the health status. Based on publicly available transcriptome datasets, we compared VTP values between the disease and health status and analyzed correlations between VTP values and disease progression or severity in various diseases, including neurological disorders, infectious diseases, cardiovascular diseases, respiratory diseases, liver diseases, kidney diseases, digestive diseases, and endocrine diseases. We also identified the genes and pathways whose expression perturbations correlated positively with VTP across diverse diseases. Results. VTP values were upregulated in various diseases relative to their normal controls. VTP values were significantly greater in define than in possible or probable Alzheimer’s disease. VTP values were significantly larger in intensive care unit (ICU) COVID-19 patients than in non-ICU patients, and in COVID-19 patients requiring mechanical ventilatory support (MVS) than in those not requiring MVS. VTP correlated positively with viral loads in acquired immune deficiency syndrome (AIDS) patients. Moreover, the AIDS patients treated with abacavir or zidovudine had lower VTP values than those without such therapies. In pulmonary tuberculosis (TB) patients, VTP values followed the pattern: active TB > latent TB > normal controls. VTP values were greater in clinically apparent than in presymptomatic malaria. VTP correlated negatively with the cardiac index of left ventricular ejection fraction (LVEF). In chronic obstructive pulmonary disease (COPD), VTP showed a negative correlation with forced expiratory volume in the first second (FEV1). VTP values increased with H. pylori infection and were upregulated in atrophic gastritis caused by H. pylori infection. The genes and pathways whose expression perturbations correlated positively with VTP scores across diseases were mainly involved in the regulation of immune, metabolic, and cellular activities. Conclusions. VTP is upregulated in the disease versus health status, and its upregulation is associated with disease progression and severity in various diseases. Thus, VTP has potential clinical implications for disease diagnosis and prognosis.

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Section: Resultsmentioning

confidence: 99%

The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various Diseases

2022

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“…The main consequence of OSA is nocturnal intermittent hypoxaemia, which, in turn, sets in motion a series of mechanisms capable of intensifying cardiovascular risk factors such as arteriosclerosis and arterial hypertension, as well as cardiovascular events, metabolic dysfunction and neuropsychiatric diseases, and making them more difficult to control [6]. Among the pathophysiological mechanisms mediated by intermittent hypoxemia to produce these phenomena are: sympathetic hyperactivity, increased plasma volume, RAS hyperactivity, increased peripheral insulin resistance, hypercoagulability, endothelial dysfunction, nocturnal fluid redistribution, sleep inefficiency, oxidative stress and inflammation [7][8][9][10][11][12][13]. Therefore, even in an initial approximation, it is already clear that some of the mechanisms capable of generating the aforementioned phenotypes of nocturnal arterial hypertension are similar to those that produce the respiratory events during sleep that define OSA.…”

Section: T He Latest European Society Of Hypertension (Esh)mentioning

confidence: 99%

Nocturnal hypertension phenotypes and obstructive sleep apnoea

Oscullo,

Gomez-Olivas,

Martínez-García

2023

Journal of Hypertension

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“…These symptoms mostly comprise chronic productive cough (usually with a purulent component) and multiple exacerbations of an infectious profile as well as chronic bronchial infection over the course of the disease’s natural history [ 2 , 3 , 4 , 5 ]. The airway inflammation usually observed in bronchiectasis is mixed, with a predominance of neutrophils [ 6 ], although some patients may also present an increase in eosinophils [ 7 , 8 , 9 ]. Bronchiectasis can be caused by underlying pulmonary and extra-pulmonary diseases [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Etiology of Bronchiectasis in the World: Data from the Published National and International Registries

Gómez-Olivas,

Oscullo,

Martínez-García

2023

JCM

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Bronchiectasis is the third leading chronic inflammatory disease of the airway caused by dozens of pulmonary and extra-pulmonary diseases. Infection by pathogenic microorganisms is very common. We aimed to analyze, for the first time in the literature, the etiology of bronchiectasis throughout the world via data published in national and international registries. A bibliographic search was carried out in PubMed and Web of Science. Seven studies were included, with a total of 27,258 patients from 33 countries of four continents. The most frequent cause of bronchiectasis was post-infectious: 30.5% (range: 19.1–40.4%), followed by idiopathic: 28.7% (18.5–38.1%). Post-tuberculous bronchiectasis accounted for 14.1% (1.8–35.5%), while etiologies associated with COPD and asthma comprised 7% (3.4–10.9%) and 5.2% (2.5–7.8%). In conclusion, there was a high degree of heterogeneity in the relative percentages of the main causes of bronchiectasis in the world, although post-infectious and idiophatic bronchiectasis continue to be the most frequent causes.

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[Translated article] Biological Biomarkers in Respiratory Diseases

Cited by 18 publications

References 183 publications

The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various Diseases

The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various Diseases

Nocturnal hypertension phenotypes and obstructive sleep apnoea

Etiology of Bronchiectasis in the World: Data from the Published National and International Registries

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