[Translated article] Chemotherapy, Alopecia, and Scalp Cooling Systems

Amarillo, Dahiana; Boni, Daniela De; Cuello, M.

doi:10.1016/j.ad.2022.02.014

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Chemotherapy-induced alopecia may have a slightly different approach. A limited number of effective prevention strategies have been reported, including scalp-cooling techniques, although with variable results and indications 82,83 . Despite the lack of benefit in preventing chemotherapy-induced alopecia, topical and oral minoxidil may help by reducing the time of hair regrowth 48 .…”

Section: Psychotropicsmentioning

confidence: 99%

Drugs and alopecia

Relvas¹,

Soares²

2023

PJDV

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Drugs are a relatively common cause of diffuse, nonscarring hair loss. They may interfere with the normal hair cycle, either by an abrupt cessation of the mitotic activity of matrix cells, causing anagen effluvium, or by an interruption of the anagen and a premature passage to the telogen phase, originating telogen effluvium. It is essential to obtain a complete history, including previous diseases and medications, focusing on the past 3 months, in order to rule out possible drug-induced alopecia. This review encompasses the most frequently involved drugs, including mechanisms of action and clinical characteristics of drug-induced alopecia. The correct recognition of drug-induced alopecia is essential since the main approach is to stop the offending agent, whenever it is possible.

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Section: Psychotropicsmentioning

confidence: 99%

Drugs and alopecia

Relvas¹,

Soares²

2023

PJDV

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“…By 2040, the number of patients requiring first-course chemotherapy each year will increase by approximately 50% to 15.0 million [ 2 ]. Among patients receiving chemotherapy, an estimated 65% are expected to develop chemotherapy-induced alopecia (CIA) and possible changes in hair pigmentation, texture, quantity, and growth [ 3 , 4 ]. While many common targeted therapies and some immunotherapies are classified as chemotherapy in the National Cancer Database (NCDB), in this review we focus on CIA induced by cytotoxic drugs [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, patients with CIA may begin to perceive certain changes in the attitudes towards them, ranging from sympathy to rejection [ 20 ]. There are excellent recent reviews on the clinical features, diagnosis, pathobiology of CIA, and CIA effects on quality of life [ 3 , 4 , 9 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Prevention and Treatment of Chemotherapy-Induced Alopecia: What Is Available and What Is Coming?

et al. 2023

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Millions of new cancer patients receive chemotherapy each year. In addition to killing cancer cells, chemotherapy is likely to damage rapidly proliferating healthy cells, including the hair follicle keratinocytes. Chemotherapy causes substantial thinning or loss of hair, termed chemotherapy-induced alopecia (CIA), in approximately 65% of patients. CIA is often ranked as one of the most distressing adverse effects of chemotherapy, but interventional options have been limited. To date, only scalp cooling has been cleared by the US Food and Drug Administration (FDA) to prevent CIA. However, several factors, including the high costs not always covered by insurance, preclude its broader use. Here we review the current options for CIA prevention and treatment and discuss new approaches being tested. CIA interventions include scalp cooling systems (both non-portable and portable) and topical agents to prevent hair loss, versus topical and oral minoxidil, photobiomodulation therapy (PBMT), and platelet-rich plasma (PRP) injections, among others, to stimulate hair regrowth after hair loss. Evidence-based studies are needed to develop and validate methods to prevent hair loss and/or accelerate hair regrowth in cancer patients receiving chemotherapy, which could significantly improve cancer patients’ quality of life and may help improve compliance and consequently the outcome of cancer treatment.

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