Translating Developmental Science to Address Childhood Adversity

Garner, Andrew S.; Forkey, Heather; Szilagyi, Moira

doi:10.1016/j.acap.2015.05.010

Cited by 57 publications

(53 citation statements)

References 66 publications

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“…In earlier work [57] we investigated the natural history of neuroendocrine changes in relation to PTSD development and maintenance in children and adolescents experiencing a single stressor, a motor vehicle accident [57, 58]. The participants had no history of previous traumatic experiences, nor current or lifetime psychopathology.…”

Section: Neuroendocrine Responses To Early-life Stress and Adult Diseasementioning

confidence: 99%

“…Of course, some degree of stress is inevitable in life, and coping with manageable stress is part of healthy development. Because the concept of distress includes the absence of protective mechanisms needed for stress recovery, an early intervention strategy includes guidance, social support, teaching positive parenting techniques, and facilitating a child’s social, cognitive, and emotional development [58-60]. …”

Section: A New Role For Pediatriciansmentioning

confidence: 99%

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Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related Disorders

Pervanidou

Chrousos²

2018

Horm Res Paediatr

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Stress exposure is highly prevalent in the general population; however, the experience of stress during vulnerable periods of development has substantial and permanent effects on brain structure and function and physical health in adulthood. Stress, the state of threatened homeostasis, is generally associated with a time-limited activation of the stress system, i.e., the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous system, tailored to the stressful stimulus also known as the stressor. On the other hand, chronic stress may be associated with lingering hyper- or hyposecretion of mediators of the stress system. This chronic condition is called dyshomeostasis, allostasis, or cacostasis and is associated with increased mental and physical morbidity in the long term. Stressful or traumatic experiences during fetal life, early childhood, and adolescence have been related to persistent neuroendocrine and epigenetic changes. Further, brain structures involved in the stress response, such as those of the stress system, the hippocampus, and the amygdala, may be programmed early on for a life of adversity.

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Section: Neuroendocrine Responses To Early-life Stress and Adult Diseasementioning

confidence: 99%

Section: A New Role For Pediatriciansmentioning

confidence: 99%

Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related Disorders

Pervanidou

Chrousos²

2018

Horm Res Paediatr

View full text Add to dashboard Cite

show abstract

“…Strategies that improve and minimize adversity in childhood and help engage parents can lead to better health outcomes. 7 This focus, including determining how to prevent subsequent utilization (eg, readmissions), is especially relevant in this era of accountable care and episode-based payments.…”

mentioning

confidence: 99%

“…After discharge, resources that build and stabilize resilience include communitybased programs that support the parent-child relationship. 7 Learning about such programs and connecting families could be a critical component of the hospital-to-home transition. Strategies that improve and minimize adversity in childhood and help engage parents can lead to better health outcomes.…”

mentioning

confidence: 99%

“…If parents have never experienced positive relationships, they may deal with trauma in maladaptive ways, living "in survival mode and focused on securing the basic essentials for life" instead of responding to the emotional cues and needs of their child. 7 In addition to teaching trainees how to identify children at risk for clinical deterioration, we should also teach how to recognize those at risk for deterioration resulting from toxic stress responses to adversity.…”

mentioning

confidence: 99%

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