Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Papa, Verónica; Marracino, Luisa; Fortini, Francesca; Rizzo, Paola; Campo, Gianluca; Vaccarezza, Mauro; Sega, Francesco Vieceli Dalla

doi:10.3390/jcm9082480

Cited by 22 publications

(15 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is now well established that the incidence of CVDs increases with aging [ 17 , 65 ], although the majority of elderly patients suffering from CVD have either no conventional risk factor or just one risk factor [ 66 , 67 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review

Papa

Tafuri

Vaccarezza

2021

IJERPH

Self Cite

View full text Add to dashboard Cite

More than 10.74 million people are currently held in penal institutions worldwide. Moreover, there is also evidence that the percentage of elder and female prisoners has been consistently growing. Cardiovascular diseases are the leading cause of death worldwide. Exercise training and physical activity help to prevent both primary and secondary cardiovascular events. Data on the influence of physical activity on the well-being in prison population is scarce. Here, we discussed, in a systematic review, the general health conditions and the cardiovascular risk profile in the prisoners compared to the general population and evaluated whether or not exercise could be a valuable tool in preventing these diseases in inmates. We performed a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement: 769 were initially identified, and a total of 24 studies were finally included. Nine studies evaluated the health conditions in prisoners, five studies evaluated the incidence of cardiovascular disease (CVD) and coronary heart disease (CHD) in the prison population, and 10 studies evaluated the feasibility and the effectiveness of exercise programs in prisoners. Sports-educational programs can benefit prison inmates. It appears that supervised exercise training is an effective coping strategy to deal with incarceration. Moreover, it seems the sports programs might be a useful tool in improving physical and mental health of prisoners as well as in decreasing cardiovascular risk factors.

show abstract

Section: Resultsmentioning

confidence: 99%

“…They demonstrated that shear stress and vascular remodeling played a crucial role in the benefits of exercise in CVD. Atherosclerosis and inflammation seem to be the cross-talking pathways between the two diseases [ 17 ], the shear stress and the remodeling of vascular endothelium being the common process both in CVD and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review

Papa

Tafuri

Vaccarezza

2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Patients were also presented when a subclonal population potentially indicating clonal hematopoiesis of indeterminate potential (CHIP) [25] was observed. CHIP, a recently described entity, is sometimes incidentally detected by NGS tests and can be a precursor to hematologic malignancies and cardiovascular disease [26]. Individuals in whom CHIP was identified (n = 5, 3%) and discussed in MTB have been referred to a CHIP clinic recently begun at Vanderbilt University Medical Center.…”

Section: Discussionmentioning

confidence: 99%

Framework for Implementing and Tracking a Molecular Tumor Board at a National Cancer Institute–Designated Comprehensive Cancer Center

Jain

Schmalz²,

Cann

et al. 2021

The Oncologist

View full text Add to dashboard Cite

Background. Over the past few years, next-generation tumor sequencing (NGS) panels have evolved in complexity and have changed from selected gene panels with a handful of genes to larger panels with hundreds of genes, sometimes in combination with paired germline filtering and/or testing. With this move toward increasingly large NGS panels, we have rapidly outgrown the available literature supporting the utility of treatments targeting many reported gene alterations making it challenging for oncology providers to interpret NGS results and make a therapy recommendation for their patients. Methods. To support the oncologists at Vanderbilt-Ingram Cancer Center (VICC) in interpreting NGS reports for patient care, we initiated two molecular tumor boards (MTBs)-a VICC-specific institutional board for our patients and a global community MTB open to the larger oncology patient

show abstract

“…As mentioned above, inflammatory signaling is one of the key mechanisms by which CHIP with somatic mutations such as TET2/DNMT3A increases risk of cardiovascular events. Likely, TET2/DNMT3A mutations increase proinflammatory cytokine release, driving a feedback loop that leads to clonal expansions of mutant dominant cells, which then again amplifies deregulated and unbalanced release of pro-inflammatory cytokines [61]. Whether other CHIPrelated mutations also increase cardiovascular risk through inflammatory mechanisms is not clear.…”

Section: Inflammatory Pathways Involved In the Mechanism By Which Chip Increases Cardiovascular Riskmentioning

confidence: 99%

A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease

Wang

Liu

et al. 2021

Mol Biol Rep

View full text Add to dashboard Cite

Age and inflammation are powerful drivers of cardiovascular disease. With the growing recognition that traditional cardiovascular risk factors are not fully accurate predictors of cardiovascular disease, recent studies have revealed the prevalence of positive selection of somatic cell mutations in hematopoietic stem cells in the elderly population, which can cause clonal hematopoiesis. Interestingly, clonal hematopoiesis is not only associated with cancer and death, but also closely related to the risk of increased cardiovascular disease due to mutations in TET2, DNMT3A, ASXL1, and JAK2. However, the mechanism of the interaction of clonal hematopoiesis and cardiovascular disease is only partially understood. In mice, somatic mutations have led to significantly increased expression of inflammatory genes in innate immune cells, which may explain the relationship between mutations and cardiovascular disease. Here, we further discuss the association between inflammatory signaling, clonal hematopoiesis, and cardiovascular disease,and using two hypotheses to propose a feedback loop between inflammatory signaling and clonal hematopoiesis for getting insight into the pathogenesis of cardiovascular diseases in depth. Therapies targeting mutant clones or increased inflammatory mediators may be useful for ameliorating the risk of cardiovascular disease.

show abstract

Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review

Cited by 22 publications

References 101 publications

Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review

Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review

Framework for Implementing and Tracking a Molecular Tumor Board at a National Cancer Institute–Designated Comprehensive Cancer Center

A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease

Contact Info

Product

Resources

About