Translating Experimental Data to Human Populations

Invited Perspective: Humanized Mice for Arsenic Metabolism—A Better Model for Investigating Arsenic-Induced Diseases?

“…Furthermore, translating a drinking water concentration from human to mouse is complicated not only by the usual issues of body surface area or body mass conversions, but also by differences between mice and humans in volume of water consumed per day and arsenic distribution, metabolism, and excretion. 14 The FDA recommends using allometric scaling to determine human equivalence of doses given to different species. 15 Using their guidelines, a dose to a mouse should be divided by to give the human equivalent dose.…”