Translating Interventional Neuroscience to Suicide: It’s About Time

Barredo, Jennifer; Bozzay, Melanie L.; Primack, Jennifer M.; Schatten, Heather T.; Armey, Michael F.; Carpenter, Linda L.; Philip, Noah S.

doi:10.1016/j.biopsych.2021.01.013

Cited by 11 publications

(10 citation statements)

References 148 publications

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“…Such data are congruous with evidence that exercising mindfulness breathing techniques for 3 weeks could improve inhibition and conflict monitoring in healthy controls [ 75 ] and patients with psychosis [ 76 ]. The possibility that MEMI optimized attention, cognitive control, and EF-related brain pathways [ 77 , 78 ] could explain these findings [ 79 ]. These hypotheses await empirical evaluation.…”

Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of a 14-day mindfulness ecological momentary intervention (MEMI) for generalized anxiety disorder

Zainal

Newman

2023

Eur. Psychiatr.

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Background. Little is known about whether brief mindfulness ecological momentary interventions (MEMIs) yield clinically beneficial effects. This gap exists despite the rapid growth of smartphone mindfulness applications. Specifically, no prior brief MEMI has targeted generalized anxiety disorder (GAD). Moreover, although theories propose that MEMIs can boost executive functioning (EF), they have largely gone untested. Thus, this randomized controlled trial (RCT) aimed to address these gaps by assessing the efficacy of a 14-day smartphone MEMI (versus self-monitoring placebo [SMP]). Method. Participants with GAD were randomly assigned to either condition (68 MEMI and 42 SMP). MEMI participants exercised multiple core mindfulness strategies and were instructed to practice mindfulness continually. Comparatively, SMP participants were prompted to practice self-monitoring and were not taught any mindfulness strategies. All prompts occurred five times a day for 14 consecutive days. Participants completed self-reports and neuropsychological assessments at baseline, posttreatment, and 1-month follow-up (1MFU). Piecewise hierarchical linear modeling analyses were conducted. Results. MEMI (versus SMP) produced greater pre-1MFU reductions in GAD severity and perseverative cognitions (between-group d = 0.393-0.394) and stronger improvements in trait mindfulness and performance-based inhibition (d = 0.280-0.303). Further, MEMI (versus SMP) led to more considerable pre-to posttreatment reduction in state-level depression and anxiety and more mindfulness gains (d = 0.50-1.13). Overall, between-treatment effects were stronger at pre-1MFU than pre-to posttreatment for trait-level than state-level treatment outcome measures. Conclusions. Preliminary findings suggest that the beneficial effect of an unguided brief MEMI to target pathological worry, trait mindfulness, and EF is modest yet potentially meaningful. Other theoretical and clinical implications were discussed.

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Section: Discussionmentioning

confidence: 99%

A randomized controlled trial of a 14-day mindfulness ecological momentary intervention (MEMI) for generalized anxiety disorder

Zainal

Newman

2023

Eur. Psychiatr.

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“…Prevailing theories on the ideation-to-action framework of suicide conceptualize distinct etiologic factors leading to the development of suicidal thoughts v. suicidal behaviors (Klonsky, Qiu, & Saffer, 2017). While there is increasing empirical support for distinct etiologic factors (Klonsky et al, 2017; Klonsky & May, 2015; Klonsky, Saffer, & Bryan, 2018), biological correlates of suicidal thoughts alone v. behaviors remain an understudied area in suicide prevention (Barredo et al, 2021; Desmyter, van Heeringen, & Audenaert, 2011; Huang, Rootes-Murdy, Bastidas, Nee, & Franklin, 2020; Jollant, Lawrence, Olie, Guillaume, & Courtet, 2011; Serafini, Pardini, Pompili, Girardi, & Amore, 2016; van Heeringen & Mann, 2014). Exploring biological correlates of suicide risk, especially through means like neuroimaging, provides insight into potential differences between those who only think about suicide v. those who subsequently progress from suicidal ideation to suicidal action(s) (Barredo et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Such theories posit that dispositional contributors, including biological factors like brain activation, may uniquely differentiate those at risk for suicidal behaviors v. suicidal thoughts alone (Klonsky & May, 2015). Neuroimaging studies of suicide have lagged behind psychosocial research, as only a few studies to date have compared individuals with suicide attempt histories to those with other STBs (Barredo et al, 2021). In a small sub-analysis, 18 individuals with current suicidal ideation and lifetime suicide attempt(s) had marginally higher connectivity between the dorsal posterior cingulate cortex and the left inferior frontal gyrus compared to 16 individuals with current suicidal ideation without lifetime suicide attempt(s) (Chase et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Resting-state network analysis of suicide attempt history in the UK Biobank

Thompson

Ghahramanlou‐Holloway

Murphy

et al. 2023

Psychol. Med.

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Background Prior research has identified altered brain structure and function in individuals at risk for self-directed violence thoughts and behaviors. However, these studies have largely utilized healthy controls and findings have been inconsistent. Thus, this study examined differences in resting-state functional network connectivity among individuals with lifetime suicide attempt(s) v. lifetime self-directed violence thoughts alone. Methods Using data from the UK Biobank, this study utilized a series of linear regressions to compare individuals with lifetime suicide attempt(s) (n = 566) v. lifetime self-directed violence thoughts alone (n = 3447) on within- and between- network resting-state functional connectivity subnetworks. Results There were no significant between-group differences for between-network, within-network, or whole-brain functional connectivity after adjusting for age, sex, ethnicity, and body mass index and performing statistical corrections for multiple comparisons. Resting-state network measures may not differentiate between individuals with lifetime suicide attempt(s) and lifetime self-directed violence thoughts alone. Conclusions Null findings diverge from results reported in smaller neuroimaging studies of suicide risk, but are consistent with null findings in other large-scale studies and meta-analyses. Strengths of the study include its large sample size and stringent control group. Future research on a wider array of imaging, genetic, and psychosocial risk factors can clarify relative contributions of individual and combined variables to suicide risk and inform scientific understanding of ideation-to-action framework.

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“…Prevailing theories on the ideation-to-action framework of suicide conceptualize distinct etiologic factors leading to the development of suicidal thoughts versus suicidal behaviors 4 . While there is increasing empirical support for distinct etiologic factors [4][5][6] , biological correlates of suicidal thoughts alone versus behaviors remain an understudied area in suicide prevention [7][8][9][10][11][12] . Exploring biological correlates of suicide risk, especially through means like neuroimaging, provides insight into potential differences between those who only think about suicide versus those who subsequently progress from suicidal ideation to suicidal action(s) 12 .…”

Section: Introductionmentioning

confidence: 99%

“…Neuroimaging studies of suicide have lagged behind psychosocial research, as only a few studies to date have compared individuals with suicide attempt histories to those with other STBs 12 . In a small sub-analysis, 18 individuals with current suicidal ideation and lifetime suicide attempt(s) had marginally higher connectivity between the dorsal posterior cingulate cortex and the left inferior frontal gyrus compared to 16 individuals with current suicidal ideation without lifetime suicide attempt(s) 16 .…”

Section: Introductionmentioning

confidence: 99%

Resting-State Network Analysis of Suicide Attempt History in the UK Biobank

Thompson

Ghahramanlou‐Holloway

Murphy

et al. 2022

Preprint

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Background: Prior research has identified altered brain structure and function in individuals at risk for self-directed violence thoughts and behaviors. However, these studies have largely utilized healthy controls and findings have been inconsistent. Thus, this study examined differences in resting-state functional network connectivity among individuals with lifetime suicide attempt(s) versus lifetime self-directed violence thoughts alone. Methods: Using data from the UK Biobank, this study utilized a series of linear regressions to compare individuals with lifetime suicide attempt(s) (n = 566) versus lifetime self-directed violence thoughts alone (n = 3,447) on within- and between- network resting-state functional connectivity subnetworks. Results: There were no significant between-group differences for between-network, within-network, or whole-brain functional connectivity after adjusting for age, sex, ethnicity, and body mass index and performing statistical corrections for multiple comparisons. Conclusions: Resting-state network measures may not differentiate between individuals with lifetime suicide attempt(s) and lifetime self-directed violence thoughts alone. Null findings diverge from results reported in smaller neuroimaging studies of suicide risk, but are consistent with null findings in other large-scale studies and meta-analyses. Strengths of the study include its large sample size and stringent control group. Future research on a wider array of imaging, genetic, and psychosocial risk factors can clarify relative contributions of individual and combined variables to suicide risk and inform scientific understanding of ideation-to-action framework.

show abstract

Translating Interventional Neuroscience to Suicide: It’s About Time

Cited by 11 publications

References 148 publications

A randomized controlled trial of a 14-day mindfulness ecological momentary intervention (MEMI) for generalized anxiety disorder

A randomized controlled trial of a 14-day mindfulness ecological momentary intervention (MEMI) for generalized anxiety disorder

Resting-state network analysis of suicide attempt history in the UK Biobank

Resting-State Network Analysis of Suicide Attempt History in the UK Biobank

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