Translating Temporal Interference Brain Stimulation to Treat Neurological and Psychiatric Conditions

Grossman, Nir; Okun, Michael S.; Boyden, Edward S.

doi:10.1001/jamaneurol.2018.2760

Cited by 43 publications

(40 citation statements)

References 8 publications

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“…For example, one attractive application of TI technologies would be non-invasive deep brain stimulation to treat a variety of neurological and psychiatric conditions, such as Parkinson's disease (Grossman et al, 2018;Lozano et al, 2019). Current deep brain stimulation approaches to treat Parkinson's disease involve implantation of electrodes in deep brain areas, such as the subthalamic nucleus.…”

Section: Discussionmentioning

confidence: 99%

Biophysics of Temporal Interference Stimulation

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Biophysics of Temporal Interference Stimulation

et al. 2020

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“…Cellular and networks biophysics are not uniform across the brain, and moreover would change with brain state 46 and disease 47 . Similarly, divergent results across animal studies (e.g.…”

Section: Discussionmentioning

confidence: 99%

Temporal interference stimulation targets deep brain regions by modulating neural oscillations

Esmaeilpour

Kronberg

Parra

et al. 2019

Preprint

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Temporal interference (TI) stimulation of the brain generates amplitude-modulated electric fields oscillating in the kHz range. A validated current-flow model of the human head estimates that amplitude-modulated electric fields are stronger in deep brain regions, while unmodulated electric fields are maximal at the cortical regions. The electric field threshold to modulate carbacholinduced gamma oscillations in rat hippocampal slices was determined for unmodulated 0.05-2 kHz sine waveforms, and 5 Hz amplitude-modulated waveforms with 0.1-2 kHz carrier frequencies. The neuronal effects are replicated with a computational network model to explore the underlying mechanisms. Experiment and model confirm the hypothesis that spatial selectivity of temporal interference stimulation depends on the phasic modulation of neural oscillations only in deep brain regions. This selectivity is governed by network adaption (e.g. GABA b ) that is faster than the amplitude-modulation frequency. The applied current required depends on the neuronal membrane time-constant (e.g. axons) approaching the kHz carrier frequency of temporal interference stimulation.

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“…145 Such noninvasive DBS could pave the way for potential treatment of poststroke motor recovery and other movement disorders. 146 Future studies should explore new techniques and translate them into practical applications.…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration

et al. 2020

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Electrical stimulation has been extensively applied in post-stroke motor restoration, but its treatment mechanisms are not fully understood. Stimulation of neuromotor control system at multiple levels manipulates the corresponding neuronal circuits and results in neuroplasticity changes of stroke survivors. This rewires the lesioned brain and advances functional improvement. This review addresses the therapeutic mechanisms of different stimulation modalities, such as noninvasive brain stimulation, peripheral electrical stimulation, and other emerging techniques. The existing applications, the latest progress, and future directions are discussed. The use of electrical stimulation to facilitate post-stroke motor recovery presents great opportunities in terms of targeted intervention and easy applicability. Further technical improvements and clinical studies are required to reveal the neuromodulatory mechanisms and to enhance rehabilitation therapy efficiency in stroke survivors and people with other movement disorders.

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Translating Temporal Interference Brain Stimulation to Treat Neurological and Psychiatric Conditions

Cited by 43 publications

References 8 publications

Biophysics of Temporal Interference Stimulation

Biophysics of Temporal Interference Stimulation

Temporal interference stimulation targets deep brain regions by modulating neural oscillations

Rewiring the Lesioned Brain: Electrical Stimulation for Post-Stroke Motor Restoration

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