2013
DOI: 10.1074/jbc.m113.472290
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Translation Initiation Requires Cell Division Cycle 123 (Cdc123) to Facilitate Biogenesis of the Eukaryotic Initiation Factor 2 (eIF2)

Abstract: Background:The eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric G-protein.Results: Cdc123, a conserved cell proliferation protein, binds the unassembled eIF2␥ subunit to promote eIF2 complex formation. Conclusion: Cdc123 is a specific eIF2 assembly factor indispensable for the onset of protein synthesis. Significance: This study describes a novel step in the eukaryotic translation initiation pathway.

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Cited by 31 publications
(52 citation statements)
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“…Based on structural studies of the archaeal and yeast complexes, eIF2g is the keystone of the eIF2 complex with separate docking sites for the eIF2a and eIF2b subunits (Schmitt et al 2012;Hussain et al 2014;Llacer et al 2015). The incorporation of eIF2g in the eIF2 complex is dependent on the apparently eIF2-specific chaperone Cdc123 (Perzlmaier et al 2013). The amino acid sequence and structure of eIF2g and aIF2g show striking similarity to elongation factor EF-Tu from bacteria (Hannig et al 1993;Schmitt et al 2002;Roll-Mecak et al 2004).…”
Section: Ternary Complex Formationmentioning
confidence: 99%
“…Based on structural studies of the archaeal and yeast complexes, eIF2g is the keystone of the eIF2 complex with separate docking sites for the eIF2a and eIF2b subunits (Schmitt et al 2012;Hussain et al 2014;Llacer et al 2015). The incorporation of eIF2g in the eIF2 complex is dependent on the apparently eIF2-specific chaperone Cdc123 (Perzlmaier et al 2013). The amino acid sequence and structure of eIF2g and aIF2g show striking similarity to elongation factor EF-Tu from bacteria (Hannig et al 1993;Schmitt et al 2002;Roll-Mecak et al 2004).…”
Section: Ternary Complex Formationmentioning
confidence: 99%
“…In vivo assembly of the eIF2 complex was shown to depend on Cdc123. Sc-Cdc123 activity involved an interaction with the unassembled eIF2γ subunit (Perzlmaier et al, 2013). eIF2γ is made of three domains: the GTP-binding domain, γDI, and the two β-barrels γDII and γDIII (Schmitt et al, 2010).…”
Section: Binding Of Cdc123 To Eif2γmentioning
confidence: 99%
“…eIF2γ is made of three domains: the GTP-binding domain, γDI, and the two β-barrels γDII and γDIII (Schmitt et al, 2010). Within eIF2γ, domain III was shown to be sufficient for binding to Cdc123 (Perzlmaier et al, 2013).…”
Section: Binding Of Cdc123 To Eif2γmentioning
confidence: 99%
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“…P2RY14 (Supplemental Spreadsheet 1), a purinergic receptor for UDP-glucose and other UDP-sugars is an asthma risk gene (52) . Finally, CDC123 (Supplemental Spreadsheet 1) is critical for the eukaryotic translation initiation factor 2 (eIF2) activity, which is required for the onset of protein synthesis (53) . Conversely, EEF2K, a kinase inhibitor of protein translation elongation (54) was one of the top 30 proteins down-regulated by IL-3 (Supplemental Spreadsheet 1).…”
Section: Resultsmentioning
confidence: 99%