Translation of three-dimensional printing of ceramics in bone tissue engineering and drug delivery

Abstract

Three-dimensional printing has opened up new perspectives in bone substitution, facilitating the production of customized scaffolds. The advances of the last few years have placed this technology at the forefront of personalized medicine and virtual surgical planning. This article presents an overview of additive MRS Bulletin Article TemplateAuthor Name/Issue Date 2 manufacturing of bioceramics for bone regeneration, covering both the additive manufacturing methods and the consolidation strategies that can be applied. We highlight the main progress made in recent years, with an insight into drug delivery applications and the advances in the translation of this technology to the biomedical industry and the clinics. Furthermore, the main challenges and future trends of this new medical technology are identified and discussed.

Translation of 3D printed materials for medical applications

“…14 Raymond et al discussed the translation of 3DP of ceramics in bone tissue engineering, drug delivery, and patient-matched personalized medicine along with current challenges. 69 Chae et al described the application of bioprinting with decellularized extracellular matrix-based bioinks in translational regenerative medicine, emphasizing musculoskeletal and cardiovascular tissue engineering. 70 Mahajan et al discussed the translation of bioprinted materials in skin, bone, cartilage, nerve, cardiac tissue, and vascular network repair, along with constructing organoids for toxicology testing as an alternative to animal studies.…”

Three-Dimensional Printed Patient-Specific Vestibular Augmentation: A Case Report

“…Today, various techniques are used to achieve ridge augmentation, such as guided bone regeneration (GBR) using bone graft granules as a filler and a membrane for confinement; bone split techniques using chisels and/or osteotomes; bone grafting with standard blocks; and customized bone grafts [3,[5][6][7]. Although GBR is a frequently used technique in vestibular augmentations, unconfined granules can migrate, making it difficult to obtain a stable volume during the bone regeneration period.…”

“…Bone split techniques are complex and, in many cases, result in high tissue morbidity. Standard blocks are beneficial for non-confined defects; however, they require onsite milling and shaping, prolonging the surgeries, and often result in a poor fit with the surgical site and high resorption of the graft [3,[5][6][7]. One strategy to shorten surgical time and improve the fit of these grafts is based on customized and pre-milled bone blocks using pre-surgical virtual planning [9].…”

“…This technology can simplify the augmentation procedure, increase the accuracy of the bone graft dimensions, and reduce surgery time. They meet all the advantages of allograft blocks while eliminating the risk of disease transfer, allowing for a precise control of the external shape and volume, which helps predict the final bone gain and the geometrical fit with the contour of the surgical site [7]. Moreover, the internal porosity of the 3D-printed constructs can be controlled and tailored for optimal vascularization and bone colonization, which is an advantage compared to solid pre-shaped blocks [7,11].…”

“…They meet all the advantages of allograft blocks while eliminating the risk of disease transfer, allowing for a precise control of the external shape and volume, which helps predict the final bone gain and the geometrical fit with the contour of the surgical site [7]. Moreover, the internal porosity of the 3D-printed constructs can be controlled and tailored for optimal vascularization and bone colonization, which is an advantage compared to solid pre-shaped blocks [7,11]. Calcium-deficient hydroxyapatite (CDHA) 3D-printed bone grafts stand out among customized synthetic bone grafts.…”