Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Tang, Hui; Ju, Haisong; Zhao, Shufang; LaDuke, Carrie; Hahn, Suzette; Glick, James M.; Carey, Cynthia; Friedrichs, Gregory S.

doi:10.1016/j.vascn.2015.09.005

Cited by 14 publications

(2 citation statements)

References 32 publications

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“…We evaluated myocardial injury by using ECG, echocardiography, TTC staining, and myocardial enzyme levels. Echocardiographic EF and FS mainly estimated systolic cardiac function [31]; these results showed that both EF and FS were significantly decreased in the MI group. TTC staining showed a significant myocardial infraction and high levels of cTnT and cTnI in MI models.…”

Section: Discussionmentioning

confidence: 88%

Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

Yuan

Wang

et al. 2021

Chin Med

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Background The pathological process of myocardial ischemia (MI) is very complicated. Acupuncture at PC6 has been proved to be effective against MI injury, but the mechanism remains unclear. This study investigated the mechanism that underlies the effect of acupuncture on MI through full-length transcriptome. Methods Adult male C57/BL6 mice were randomly divided into control, MI, and PC6 groups. Mice in MI and PC6 group generated MI model by ligating the left anterior descending (LAD) coronary artery. The samples were collected 5 days after acupuncture treatment. Results The results showed that treatment by acupuncture improved cardiac function, decreased myocardial infraction area, and reduced the levels of cTnT and cTnI. Based on full-length transcriptome sequencing, 5083 differential expression genes (DEGs) and 324 DEGs were identified in the MI group and PC6 group, respectively. These genes regulated by acupuncture were mainly enriched in the inflammatory response pathway. Alternative splicing (AS) is a post-transcriptional action that contributes to the diversity of protein. In all samples, 8237 AS events associated with 1994 genes were found. Some differential AS-involved genes were enriched in the pathway related to heart disease. We also identified 602 new genes, 4 of which may the novel targets of acupuncture in MI. Conclusions Our findings suggest that the effect of acupuncture on MI may be based on the multi-level regulation of the transcriptome.

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Section: Discussionmentioning

confidence: 88%

Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

Yuan

Wang

et al. 2021

Chin Med

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“…Monitoring of the cardiac motion is desired in a number of applications. 2D-, 3D-and Doppler-echocardiography (Mandinov et al 2000;Zamorano et al 2009;Tang et al 2016), together with cardiac MRI by myocardial tissue tagging (Shehata et al 2009;Wu et al 2014), are the imaging modalities of choice for clinical evaluation of both global and regional myocardial function. Despite them being non-invasive, fast and widely available, the accuracy of these measurements is limited by image and signal quality.…”

Section: Introductionmentioning

confidence: 99%

Packaging of implantable accelerometers to monitor epicardial and endocardial wall motion

Brancato

Weydts

Oosterlinck

et al. 2017

Biomed Microdevices

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Acceleration signals, collected from the inner and the outer heart wall, offer a mean of assessing cardiac function during surgery. Accelerometric measurements can also provide detailed insights into myocardial motion during exploratory investigations. Two different implantable accelerometers to respectively record endocardial and epicardial vibrations, have been developed by packaging a commercially available capacitive transducer. The same coating materials have been deposited on the two devices to ensure biocompatibility of the implants: Parylene-C, medical epoxy and Polydimethylsiloxane (PDMS). The different position-specific requirements resulted in two very dissimilar sensor assemblies. The endocardial accelerometer, that measures accelerations from the inner surface of the heart during acute animal tests, is a 2 mm-radius hemisphere fixed on a polymethyl methacrylate (PMMA) rod to be inserted through the heart wall. The epicardial accelerometer, that monitors the motion of the outer surface of the heart, is a three-legged structure with a stretchable polytetrafluoroethylene (PTFE) reinforcement. This device can follow the continuous motion of the myocardium (the muscular tissue of the heart) during the cardiac cycle, without hindering its natural movement. Leakage currents lower than 1 μA have been measured during two weeks of continuous operation in saline. Both transducers have been used, during animal tests, to simultaneously record and compare acceleration signals from corresponding locations on the inner and the outer heart wall of a female sheep.

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LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p/TRAF6/NF-κB Axis

Xing

et al. 2020

Biochem Genet

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Translational assessment of cardiac contractility by echocardiography in the telemetered rat

Cited by 14 publications

References 32 publications

Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

Full-length transcriptome analysis reveals the mechanism of acupuncture at PC6 improves cardiac function in myocardial ischemia model

Packaging of implantable accelerometers to monitor epicardial and endocardial wall motion

LncRNA MIAT Promotes Inflammation and Oxidative Stress in Sepsis-Induced Cardiac Injury by Targeting miR-330-5p/TRAF6/NF-κB Axis

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