Traditional research in the health sciences has involved control and experimental groups of patients, and descriptive and inferential
statistical analyses performed on the measurements obtained from the samples in each group. As the novel model of translational
healthcare, which integrates translational research and translational effectiveness, becomes increasingly established in modern
contemporary medicine, healthcare continues to evolve into a model of care that is evidence-based, effectiveness-focused and patientcentered.
Patient-centered care requires the timely and critical development and validation of a new research paradigm, which is referred
to as “individual patient research (IPR)”, as opposed as the customary group research approach. That is to say, research in geriatric disease
conditions, such as Alzheimer’s Disease (AD) must be performed from the viewpoint of individual patient research outcomes, and
individual patient data analysis. Here, we discuss IPR in patients with AD in the context of the best available research evidence that
indicates psychological symptoms, endocrine deregulation, and immune alterations in AD. We propose a clinical adaptive cluster
randomized stepped wedge blinded controlled trial, with sequential with sequential roll-out of an evidence-based intervention in a
crossover paradigm.