Translational Molecular Self-Diffusion in Magnetic Resonance Imaging

Wesbey, George E.; Moseley, Michael E.; Ehman, Richard L.

doi:10.1097/00004424-198411000-00004

Cited by 70 publications

(64 citation statements)

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“…[24][25][26][27] Diffusion MRI is a non-invasive MRI technique that allows in vivo characterization and quantification of the molecular water diffusion in tissues by measuring a series of functional parameters that reveal the water diffusion in a microscopic environment, which can serve to characterize the pathological conditions of breast lesions. 21,28,29 The measurement of the water diffusivity has been shown to help distinguish between normal fibroglandular breast tissues and benign or malignant lesions. Full paper: Diffusion kurtosis imaging in breast lesions BJR However, benign and malignant lesions cannot always be distinguished from each other based only on their diffusion rate values, because of a wide overlap between them; so, advanced diffusion MRI techniques are needed for better characterization and differentiation of the breast lesions.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

Christou

Ghiatas²,

Priovolos

et al. 2017

BJR

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Objective: The aim of this study was to evaluate the accuracy of diffusion kurtosis in the characterization and differentiation of breast lesions. Methods: 49 females with 53 breast lesions underwent breast MRI. The MRI magnetic field is 1.5 T, and the protocol is standard MRI sequences, dynamic sequences pre-and post-contrast agent administration and diffusion images. Diffusion kurtosis imaging (DKI) was applied as part of our standard breast MRΙ protocol. Two experienced radiologists on breast MRI, blinded to the final diagnosis, reviewed the parametric maps and placed a volume of interest on all slices including each lesion. Kurtosis [K apparent (K app )] and corrected apparent diffusion coefficient [D apparent (D app )] median values were then calculated from the whole-lesion histogram analysis. Receiver-operating characteristic analysis was used to determine the most effective cut-off values for the differentiation between benign and malignant pathologies. Histological analysis of the breast lesions was performed, and further comparative analysis of the results was performed to investigate the accuracy of the method. Conclusion: DKI is an accurate additional tool for the characterization and differentiation of breast lesions with high K app and D app sensitivity and specificity rates. Advances in knowledge: DKI is able to distinguish benign from malignant breast pathologies. DKI increases the specificity of breast MRI. INTRODUCTIONBreast MRI is a well-established method for the evaluation of breast pathologies. It is widely used as a supplementary modality to mammography and ultrasound, mainly for local staging of recently diagnosed breast cancers and recently as a screening tool for patients at a high risk.

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Section: Discussionmentioning

confidence: 99%

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

Christou

Ghiatas²,

Priovolos

et al. 2017

BJR

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“…The idea of measuring anisotropic diffusion in tissue fibres in humans was pointed out in one of the first papers on DWI. 13 Early measurements of water diffusion in normal human brain white matter in vivo by Thomsen et al showed large variations of the ADC.…”

Section: Early Observationsmentioning

confidence: 99%

The basis of anisotropic water diffusion in the nervous system – a technical review

2002

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Anisotropic water diffusion in neural fibres such as nerve, white matter in spinal cord, or white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to track fibre pathways. The fact that water diffusion is sensitive to the underlying tissue microstructure provides a unique method of assessing the orientation and integrity of these neural fibres, which may be useful in assessing a number of neurological disorders. The purpose of this review is to characterize the relationship of nuclear magnetic resonance measurements of water diffusion and its anisotropy (i.e. directional dependence) with the underlying microstructure of neural fibres. The emphasis of the review will be on model neurological systems both in vitro and in vivo. A systematic discussion of the possible sources of anisotropy and their evaluation will be presented followed by an overview of various studies of restricted diffusion and compartmentation as they relate to anisotropy. Pertinent pathological models, developmental studies and theoretical analyses provide further insight into the basis of anisotropic diffusion and its potential utility in the nervous system.

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“…The development of MRI techniques that are sensitive to regional blood volume and regional blood flow, 22,23 regional diffusion of water, 24 and most importantly, regional blood oxygenation 25 ushered in the age of functional MRI. The impact of functional MRI has grown rapidly.…”

Section: Functional Mrimentioning

confidence: 99%

New developments in magnetic resonance imaging of the brain

Koretsky

2004

Neurotherapeutics

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Summary:Magnetic resonance imaging (MRI) continues to have a large impact on the diagnosis and management of a number of diseases, especially diseases associated with brain injury. The strengths of MRI are the unique contrast that can be obtained, and the fact that it is not harmful and that it can be readily applied to human and animal models. The past decade has seen development of functional MRI techniques that measure aspects of hemodynamics and water diffusion that are playing an important role. Indeed, these techniques are having a major impact on management of brain injury. The development of MRI continues at a rapid pace and a renewed push to increased spatial and temporal resolution will extend the applicability of anatomical and functional MRI. Increased interest in molecular imaging using MRI is increasing the number of processes that can be imaged in the brain. This work reviews some new developments that are being made in anatomical, functional, and molecular MRI of the brain, with comments about usefulness for work in the area of neuroprotection.

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Translational Molecular Self-Diffusion in Magnetic Resonance Imaging

Cited by 70 publications

References 0 publications

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

Accuracy of diffusion kurtosis imaging in characterization of breast lesions

The basis of anisotropic water diffusion in the nervous system – a technical review

New developments in magnetic resonance imaging of the brain

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