Translational Neuroimaging: Positron Emission Tomography Studies of Monoamine Oxidase

Fowler, Joanna S.; Logan, Jean; Volkow, Nora D.; Wang, Gene‐Jack

doi:10.1007/s11307-005-0016-1

Cited by 74 publications

(56 citation statements)

References 78 publications

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“…These results are consistent with previous imaging studies of MAO A and B. Although both subtypes are highest in the thalamus, MAO A is higher in cortical regions than MAO B (Fowler et al, 2005). It is important to remember that, Figure 2.…”

Section: Discussionsupporting

confidence: 91%

Brain Monoamine Oxidase A Activity Predicts Trait Aggression

Alia‐Klein¹,

Goldstein²,

Kriplani³

et al. 2008

J. Neurosci.

223

137

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The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in the MAO A gene (MAOA, Mendelian Inheritance in Men database number 309850, referred to as high or low based on transcription in non-neuronal cells) has been investigated in a number of externalizing behavioral and clinical phenotypes. These studies provide evidence linking the low MAOA genotype and violent behavior but only through interaction with severe environmental stressors during childhood. Here, we hypothesized that in healthy adult males the gene product of MAO A in the brain, rather than the gene per se, would be associated with regulating the concentration of brain amines involved in trait aggression. Brain MAO A activity was measured in vivo in healthy nonsmoking men with positron emission tomography using a radioligand specific for MAO A (clorgyline labeled with carbon 11). Trait aggression was measured with the multidimensional personality questionnaire (MPQ). Here we report for the first time that brain MAO A correlates inversely with the MPQ trait measure of aggression (but not with other personality traits) such that the lower the MAO A activity in cortical and subcortical brain regions, the higher the self-reported aggression (in both MAOA genotype groups) contributing to more than one-third of the variability. Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression.

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Section: Discussionsupporting

confidence: 91%

Brain Monoamine Oxidase A Activity Predicts Trait Aggression

Alia‐Klein¹,

Goldstein²,

Kriplani³

et al. 2008

J. Neurosci.

223

137

View full text Add to dashboard Cite

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“…Activity in the cell is restored only by synthesis of new MAO B, a slow process with a half-life of 9 days in rat brain (Youdim and Tipton, 2002). For the best pharmacological effect, MAO B must be more than 90% inhibited (Fowler et al, 2005). The recovery of MAO B in human brain was followed using PET, revealing a recovery period of about 40 days (Fowler et al, 2005, Fowler et al, 2015.…”

Section: Irreversible and Reversible Inhibition Of Mao Bmentioning

confidence: 99%

“…For the best pharmacological effect, MAO B must be more than 90% inhibited (Fowler et al, 2005). The recovery of MAO B in human brain was followed using PET, revealing a recovery period of about 40 days (Fowler et al, 2005, Fowler et al, 2015. enzyme is added to the substrate and inhibitor at the same time.…”

Section: Irreversible and Reversible Inhibition Of Mao Bmentioning

confidence: 99%

Molecular aspects of monoamine oxidase B

Ramsay

2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Graphical abstract Highlights• MAO B activity depends on both amine and oxygen concentrations KeywordsMonoamine oxidase B; kinetics; drug design; neurotransmitter levels; platelet AbbreviationsAlzheimer's Disease, AD; Parkinson's Disease, PD; dopamine transporter, DAT; serotonin transporter, SERT; noradrenaline transporter, NET; the vesicular transporter, VMAT; Gprotein coupled receptor, GPCR; induced pluripotent stem cells, iPSC; serotonin reuptake inhibitor, SSRI; brain-derived neurotrophic factor, BDNF; multi-target designed ligands, MTDL; IC 50 , the concentration of compound required to inhibit a specified assay by 50%; K i , a kinetically measured inhibitor dissociation constant. Word count -approx 5490 (excluding references). Abstract 196 words.3

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“…The enzyme MAO-B exists on the outer mitochondrial membrane, occurring predominantly in astrocytes (9,10). The PET tracer 11 C-deuterium-L-deprenyl ( 11 C-DED) has high affinity and specificity for MAO-B (11); a previous PET study with 11 C-DED has shown that MAO-B increases in most brain regions in healthy older individuals (12).…”

mentioning

confidence: 99%