2010
DOI: 10.1074/jbc.m109.089755
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Translational Regulation of Gene Expression by an Anaerobically Induced Small Non-coding RNA in Escherichia coli

Abstract: Small non-coding RNAs (sRNA) have emerged as important elements of gene regulatory circuits. In enterobacteria such as Escherichia coli and Salmonella many of these sRNAs interact with the Hfq protein, an RNA chaperone similar to mammalian Sm-like proteins and act in the post-transcriptional regulation of many genes. A number of these highly conserved ribo-regulators are stringently regulated at the level of transcription and are part of major regulons that deal with the immediate response to various stress co… Show more

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Cited by 103 publications
(108 citation statements)
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“…FnrS is involved in gene regulation after the shift from aerobic to anaerobic conditions, and its expression is activated by the transcription factors FNR and ArcA (20,21). The combination of existing information (45) with our predictions and verifications for FnrS results in a remarkable complex regulatory network ( Fig.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…FnrS is involved in gene regulation after the shift from aerobic to anaerobic conditions, and its expression is activated by the transcription factors FNR and ArcA (20,21). The combination of existing information (45) with our predictions and verifications for FnrS results in a remarkable complex regulatory network ( Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, single-organism-specific targets are likely to be missed, as are interactions that generally are not predictable by the underlying IntaRNA algorithm (e.g., double-kissing hairpin complexes). For example, the metE-FnrS interaction [verified in E. coli (20)] seems to be conserved or detectable only in three of the eight included species (SI Appendix, Fig. S12).…”
Section: Discussionmentioning
confidence: 99%
“…Most of the intergenic sRNAs characterized to date, bind to the 5' UTR of mRNAs most often inhibiting translation by base pairing with the ribosome-binding site (RBS) or upstream of the AUG codon of the mRNA (45,46). Trans-encoded sRNAs can also activate translation of their target mRNAs when base pairing of the sRNA disrupts an inhibitory secondary structure that sequesters the RBS ( [47][48][49]. sRNA-mRNA duplexes are often degraded by RNase E or RNase III, the two major endoribonucleases in bacteria.…”
Section: Trans-encoded Srnasmentioning
confidence: 99%
“…(Figure 12). PhrS activates the translation of the pqsR gene by base-pairing with a short untranslated open reading frame (uof) to which the pqsR gene is translationally coupled (47).…”
Section: Pseudomonas Aeruginosamentioning
confidence: 99%
“…The global regulator FNR binds upstream of the mRNA encoding gene dbpA in E. coli, but does not control its expression . Instead, FNR activates the expression of FnrS, an sRNA encoded within the dbpA regulatory region (Boysen et al, 2010;Durand & Storz, 2010). Hence, apparently cryptic regulator binding can be associated with the control of sRNA expression (Fig.…”
Section: Regulation Of Srna Expressionmentioning
confidence: 99%