Translational research in radiobiology in the framework of France HADRON national collaboration

Rodriguez-Lafrasse, Claire; Saintigny, Yannick; Chevalier, François; Bernaudin, Myriam; Laurent, Carine; Pouzoulet, F.; Prezado, Yolanda; Mégnin-Chanet, Frédérique; François, Agnès; Guipaud, Olivier; Beuve, Michaël; Balosso, Jacques

doi:10.21037/tcr.2017.06.33

Cited by 1 publication

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“…In 2022, we will be able to propose to our patients carbon beam irradiation, and definitely clinical carbon beam irradiation combined with PARPi will be the next clinical research step. However pending the arrival of this hadrontherapy facilities 49 hadronbiology still needs exhaustive research. While it could be considered an efficient antitumor therapy 14 , the high sensitivity of human neural stem cells to carbon ion beams could limit its use in clinical practice 50 .…”

Section: Discussionmentioning

confidence: 99%

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation

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Chevalier

El-Habr

et al. 2018

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Despite continuous improvements in treatment of glioblastoma, tumor recurrence and therapy resistance still occur in a high proportion of patients. One underlying reason for this radioresistance might be the presence of glioblastoma cancer stem cells (GSCs), which feature high DNA repair capability. PARP protein plays an important cellular role by detecting the presence of damaged DNA and then activating signaling pathways that promote appropriate cellular responses. Thus, PARP inhibitors (PARPi) have recently emerged as potential radiosensitizing agents. In this study, we investigated the preclinical efficacy of talazoparib, a new PARPi, in association with low and high linear energy transfer (LET) irradiation in two GSC cell lines. Reduction of GSC fraction, impact on cell proliferation, and cell cycle arrest were evaluated for each condition. All combinations were compared with a reference schedule: photonic irradiation combined with temozolomide. The use of PARPi combined with photon beam and even more carbon beam irradiation drastically reduced the GSC frequency of GBM cell lines in vitro. Furthermore, talazoparib combined with irradiation induced a marked and prolonged G2/M block, and decreased proliferation. These results show that talazoparib is a new candidate that effects radiosensitization in radioresistant GSCs, and its combination with high LET irradiation, is promising.

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Section: Discussionmentioning

confidence: 99%

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation

Lesueur

Chevalier

El-Habr

et al. 2018

Sci Rep

Self Cite

View full text Add to dashboard Cite

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Translational research in radiobiology in the framework of France HADRON national collaboration

Abstract: is a French national collaboration that brings together 26 teams in nine different French cities (Lyon,

Cited by 1 publication

References 35 publications

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation

Radiosensitization Effect of Talazoparib, a Parp Inhibitor, on Glioblastoma Stem Cells Exposed to Low and High Linear Energy Transfer Radiation

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