Translational strategies in drug development for knee osteoarthritis

Cowan, Kyra J.; Kleinschmidt-Dörr, Kerstin; Gigout, Anne; Moreau, Flavie; Kraines, Jeff; Townsend, Robert M.; Dolgos, Hugues; DeMartino, Julie A.

doi:10.1016/j.drudis.2020.03.015

Cited by 7 publications

(2 citation statements)

References 60 publications

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“…The treatment methods for KOA include mainly surgical treatment, drug treatment, and physical therapy [23][24][25], and drug therapy for KOA comprises mainly nonsteroidal anti-inflammatory drugs and glucosamine [26]. Although the application of these drugs alleviates the pain or improves the activity of KOA patients, the objective adverse reactions and high costs of these drugs are still key problems that need to be solved.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis

Zhao

Liang

Pan

et al. 2022

BioMed Research International

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Aim. The aim of this study is to provide evidence of the effect of Duhuo Jisheng decoction (DHJSD) on knee osteoarthritis (KOA) of the cold-dampness obstruction syndrome type. Methods. We searched PubMed, Embase, the Cochrane Library, the China National Knowledge Infrastructure, the Wanfang database, and the China Biology Medicine for randomized controlled trials (RCTs) evaluating DHJSD or DHJSD combined with other conventional therapies (DHJSD group) compared to conventional therapy (control group) for cold-dampness obstruction syndrome-type KOA. We calculated the pooled odds ratio (OR), mean difference (MD), and 95% confidence interval (CI) using fixed- or random-effects models. Results. Eleven RCTs, with a total of 895 patients, were included. The results showed that DHJSD could significantly improve the effective rate ( OR = 3.13 , 95 % CI = 2.07 to 4.72, P < 0.001 ), reduce both the WOMAC ( MD = − 12.06 , 95 % CI = -16.34 to -7.79, P < 0.001 ) and VAS ( MD = − 1.02 , 95 % CI = -1.54 to -0.50, P = 0.0001 ) scores, and reduce the serum IL-6 ( MD = − 0.80 , 95 % CI = -0.90 to -0.69, P < 0.001 ) and TNF-α ( MD = − 2.49 , 95 % CI = -2.77 to -2.21, P < 0.001 ) levels during the treatment of cold-dampness obstruction syndrome-type KOA. The subgroup analysis showed that compared with glucosamine sulfate (GS) alone, DHJSD combined with GS significantly improved the effective rate ( OR = 2.59 , 95 % CI = 1.19 to 5.65, P = 0.02 ) and reduced the WOMAC ( MD = − 13.83 , 95 % CI = -16.14 to -11.51, P < 0.001 ) and VAS ( MD = − 0.91 , 95 % CI = -1.27 to -0.55, P < 0.001 ) scores. DHJSD + warm-needle acupuncture (WA) lowered the VAS score more than WA alone. There was no significant difference in the decrease in serum IL-1β between the DHJSD and control groups. Conclusion. This study shows that DHJSD can improve the clinical efficacy and reduce the VAS and WOMAC scores in the treatment of cold-dampness obstruction syndrome-type KOA. Compared with GS or WA alone, the combined application of DHJSD with GS or WA could better reduce both the VAS and WOMAC scores.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis

Zhao

Liang

Pan

et al. 2022

BioMed Research International

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“…KOA, a common disease affecting middle-aged and elderly individuals, poses challenges to their physical and mental health. 20 The cause of KOA is still unknown, and there is a lack of effective conservative treatments. 21 Clinicians are particularly interested in intra-articular injection of PRP or HA for KOA.…”

Section: Discussionmentioning

confidence: 99%

The Analysis Study of Association of Pharmacological Treatments With Long-Term Pain Control in Patients With Knee Osteoarthritis : A Comprehensive Systematic Review

Yulanda Putra,

Tri Lestari,

Saputra

et al. 2024

JARMHS

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Background: Knee osteoarthritis (KOA) is a degenerative joint disease affecting 10 of males and 13 of women aged 60 or older. It causes joint discomfort, weakened muscles, and physical limitations. Treatment consists of surgical and non-surgical approaches, with knee arthroplasty being the most successful. Non-regenerative therapies like ozone, corticosteroids, and prolotherapy are popular but short-lived. Chinese herbal medicine (CHM) is widely used to treat KOA, targeting specific biological processes associated with the disease. Methods: Following PRISMA 2020 guidelines, this systematic review concentrated on full-text English literature published between 2014 and 2024. Editorials and review articles that appeared in the same journal as the submission were not accepted without a DOI. A number of websites, including ScienceDirect, PubMed, and SagePub, were utilized to gather the literature. Result: The study looked at more than 200 publications using reputable sources including Science Direct, SagePub, and PubMed. After it was decided that eight publications needed greater investigation, a more extensive review of the entire literature was carried out. Conclusion: Knee osteoarthritis is a common disease affecting middle-aged and elderly individuals. Platelet-rich plasma (PRP) injections, combined with hyaluronic acid, can alleviate knee pain and improve function. However, the efficacy varies depending on the formulation. Traditional Chinese herbal medicine has shown potential in treating KOA, but its effectiveness and safety remain debatable due to limited clinical trials and methodological rigor

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Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY® (M6495) using the neo-epitope ARGS as a biomarker

Pereira,

Ottevaere,

Serruys

et al. 2024

J Pharmacokinet Pharmacodyn

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Translational strategies in drug development for knee osteoarthritis

Cited by 7 publications

References 60 publications

Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis

Efficacy of Duhuo Jisheng Decoction for Treating Cold-Dampness Obstruction Syndrome-Type Knee Osteoarthritis: A Pooled Analysis

The Analysis Study of Association of Pharmacological Treatments With Long-Term Pain Control in Patients With Knee Osteoarthritis : A Comprehensive Systematic Review

Translational pharmacokinetic and pharmacodynamic modelling of the anti-ADAMTS-5 NANOBODY® (M6495) using the neo-epitope ARGS as a biomarker

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