Translesion DNA Synthesis and Carcinogenesis

Shilkin, Evgeniy S.; Boldinova, Elizaveta O.; Stolyarenko, Anastasia D.; Гончарова, Р. И.; Chuprov‐Netochin, Roman N.; Хайруллин, Р З; Smal, M. P.; Makarova, Аlena V.

doi:10.1134/s0006297920040033

Cited by 9 publications

(8 citation statements)

References 116 publications

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“…REV1 also binds to other inserter polymerases Polη, ι, κ, and the PolD3 subunit of Polζ, and REV1 itself possesses deoxycytidyl transferase activity; thus, REV1 is thought to be a hub protein of the TLS machinery [ 50 , 51 , 52 ]. When the replication fork encounters damage on template DNA, REV1 binds to monoubiquitinated proliferating cell nuclear antigen (PCNA) at the lesion and recruits inserter polymerases Polη, ι, and κ to the damaged site, as well as Polζ via interaction with REV7 or PolD3, although the mechanistic details remain controversial ( Figure 2 ) [ 6 , 53 , 54 , 55 , 56 ]. The transcription factor TFII-I also binds to PCNA and REV7 and promotes TLS by connecting Polζ with PCNA [ 57 ].…”

Section: Role Of Rev7 In Translesion Dna Synthesis and Dna Damage-ind...mentioning

confidence: 99%

“…It was soon revealed that S. cerevisiae Rev7 and Rev3 proteins form a complex, resulting in mutagenic DNA polymerase ζ (Polζ), in which Rev3 is the catalytic subunit and Rev7 is the accessory subunit [ 4 ]. Polζ is involved in translesion DNA synthesis (TLS), which is a DNA damage-tolerance mechanism that synthesizes DNAs through damaged sites of the template DNAs [ 5 , 6 ]. Human REV7 (also known as MAD2L2 , MAD2B , MAD2β, and FANCV ) was identified as a homologous gene to spindle assembly checkpoint gene MAD2 , as well as to yeast REV7 ; therefore, research into REV7 was first progressed in the fields of TLS and cell cycle checkpoint [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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REV7 in Cancer Biology and Management

Murakumo

Sakurai

Kato

et al. 2023

Cancers

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DNA repair and cell cycle regulation are potential biological fields to develop molecular targeting therapies for cancer. Human REV7 was originally discovered as a homologous molecule to yeast Rev7, which is involved in DNA damage response and mutagenesis, and as the second homolog of yeast Mad2, involved in the spindle assembly checkpoint. Although REV7 principally functions in the fields of DNA repair and cell cycle regulation, many binding partners of REV7 have been identified using comprehensive analyses in the past decade, and the significance of REV7 is expanding in various other biological fields, such as gene transcription, epigenetics, primordial germ cell survival, neurogenesis, intracellular signaling, and microbial infection. In addition, the clinical significance of REV7 has been demonstrated in studies using human cancer tissues, and investigations in cancer cell lines and animal models have revealed the greater impacts of REV7 in cancer biology, which makes it an attractive target molecule for cancer management. This review focuses on the functions of REV7 in human cancer and discusses the utility of REV7 for cancer management with a summary of the recent development of inhibitors targeting REV7.

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Section: Role Of Rev7 In Translesion Dna Synthesis and Dna Damage-ind...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

REV7 in Cancer Biology and Management

Murakumo

Sakurai

Kato

et al. 2023

Cancers

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“…First calculations of a house without heating were presented by Wolfgang Feist and Bo Adamson for climate conditions of Germany in 1988 [1][2][3][4], later this concept was become known as the concept of a passive house. In Russia, interest to this topic has been actively developing over the past decade, research and development of concepts of houses with zero energy consumption have been published [5][6][7][8][9].…”

Section: Problem Of Construction Of Energy Efficient Housementioning

confidence: 99%

Using of BIM, BEM and CFD technologies for design and construction of energy-efficient houses

Султангузин

Kruglikov

Yatsyuk³

et al. 2019

E3S Web Conf.

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The article presents the concept and the process of integrated design and construction of energyefficient house during the life cycle based on the use of BIM (Building Information Model), BEM (Building Energy Modeling) and CFD (Computational Fluid Dynamics) technologies. The task of complex design is to create a house with harmonious architecture and minimal energy costs to maintain a comfortable microclimate, including using renewable energy sources. The article shows the effectiveness of the use of an integrated approach in the design of a house close to the Passive House standards.

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“…DNA damage can lead to genomic instability and carcinogenesis ( Hoeijmakers, 2009 ; Shilkin et al, 2020 ). TLS serves as a DNA damage tolerance mechanism by allowing DNA replication to persevere in the presence of DNA lesions.…”

Section: Introductionmentioning

confidence: 99%

Beyond the Lesion: Back to High Fidelity DNA Synthesis

Kaszubowski

Trakselis

2022

Front. Mol. Biosci.

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High fidelity (HiFi) DNA polymerases (Pols) perform the bulk of DNA synthesis required to duplicate genomes in all forms of life. Their structural features, enzymatic mechanisms, and inherent properties are well-described over several decades of research. HiFi Pols are so accurate that they become stalled at sites of DNA damage or lesions that are not one of the four canonical DNA bases. Once stalled, the replisome becomes compromised and vulnerable to further DNA damage. One mechanism to relieve stalling is to recruit a translesion synthesis (TLS) Pol to rapidly synthesize over and past the damage. These TLS Pols have good specificities for the lesion but are less accurate when synthesizing opposite undamaged DNA, and so, mechanisms are needed to limit TLS Pol synthesis and recruit back a HiFi Pol to reestablish the replisome. The overall TLS process can be complicated with several cellular Pols, multifaceted protein contacts, and variable nucleotide incorporation kinetics all contributing to several discrete substitution (or template hand-off) steps. In this review, we highlight the mechanistic differences between distributive equilibrium exchange events and concerted contact-dependent switching by DNA Pols for insertion, extension, and resumption of high-fidelity synthesis beyond the lesion.

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Translesion DNA Synthesis and Carcinogenesis

Cited by 9 publications

References 116 publications

REV7 in Cancer Biology and Management

REV7 in Cancer Biology and Management

Using of BIM, BEM and CFD technologies for design and construction of energy-efficient houses

Beyond the Lesion: Back to High Fidelity DNA Synthesis

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