Translocation (2;3) and myeloid disorders

Translocation (2;3)(p21;q26) as the Sole Anomaly in a Case of Primary Myelofibrosis

“…The same conclusion can be drawn from CML patients where the detection of the t(2p;3q) coincided with rapid conversion to blast crisis [8,9]. Our observation also confirms previously established correlations between rapid blastic transformation and 3q abnormalities [13,14]. Other common features of 3q26 aberrations are also encountered, such as an abnormal platelet count and micromegakaryocytes [14].…”

“…Other common features of 3q26 aberrations are also encountered, such as an abnormal platelet count and micromegakaryocytes [14]. Finally, our observation further confirms that t(2;3) appears in a pluripotent stem cell, is associated with a poor prognosis, and constitutes a nonrandom chromosomal anomaly associated with myeloid disorders [1][2][3][4][5][6][7][8][9]13]. Kwong et al [8] M/16 CML (blastic phase) 46,Y,der(X)t(X;9)(p22;q22),t(2;3)(p13;q26), t(9;22)(q34;q11)…”