Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization

Popp, Susanne; Jauch, Anna; Qiu, Jing; Smialek, Barbara; Cremer, Thomas; Becher, R.

doi:10.1016/0165-4608(91)90195-z

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…Recent studies demonstrated that the newly developed FISH method has provided additional resources to improve the analysis of chromosome abnormalities. It can verify the involved segments of the chromosomes not only in metaphase but also in interphase cells, and help interpret marker chromosomes that cannot be identified by banding techniques along [10][11][12][13][14][15]. However, the FISH method itself has some restrictions: first, its performance needs freshly made metaphase spreads; second, FISH results from unbanded slides must be interpreted conservatively regarding complex karyotypes.…”

Section: Discussionmentioning

confidence: 99%

Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

1997

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In this study, we have performed fluorescence in situ hybridization (FISH) with chromosome-specific DNA painting probes 1, 2, 3, 4, 6, 8, and 12 and centromere-specific DNA probes 7, 10, 12, 17, 18, and X after G-banding on the same metaphase spreads from four patients with malignant hematological disorders to more precisely interpret their complex karyotypes. The findings demonstrated that the application of combined G-banding and FISH can more accurately explain complex karyotypes of hematological malignancies. FISH can detect not only the origin of marker chromosomes, but also the complex rearrangements that cannot be identified by routine banding techniques. This approach is very important to complement the cytogenetic analysis of malignant disorders and to evaluate the role of chromosome change in the development, progression, and prognosis of tumors. Am. J. Hematol. 55:69-76, 1997.

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Section: Discussionmentioning

confidence: 99%

Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

1997

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“…It is very often extremely difficult to assign small pieces of rearranged chromosomal material by banding techniques, whereas painting of the chromosome in question visualizes even small translocated material of the targeted chromosome [156]. Chromosome painting can be used for detecting numerical as well as structural aberrations of a particular chromosome (e.g., chromosome 21 aberrations diagnostic for Down's Syndrome) [48,59,67,69,157].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Analysis of genes and chromosomes by nonisotopic in situ hybridization

Lichter

Boyle

Cremer

et al. 1991

Genetic Analysis: Biomolecular Engineering

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224

102

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“…It has also been widely used for molecular cytotaxonomy, for example of primates (Muller et al 1999; Wienberg et al 1990), mutagenicity testing (Marshall and Obe 1998) and radiation biology (Gray et al 1992). High resolution CP-based analyses have become especially important to pre-, neo- and postnatal clinical diagnostics of various chromosomal aberrations associated with human diseases and malignancies (Gray and Pinkel 1992; Popp et al 1991; Tkachuk et al 1991; Weise et al 2003; Xu et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Painting the chromosomes of Brachypodium—current status and future prospects

et al. 2011

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Chromosome painting is one of the most powerful and spectacular tools of modern molecular cytogenetics, enabling complex analyses of nuclear genome structure and evolution. For many years, this technique was restricted to the study of mammalian chromosomes, as it failed to work in plant genomes due mainly to the presence of large amounts of repetitive DNA common to all the chromosomes of the complement. The availability of ordered, chromosome-specific BAC clones of Arabidopsis thaliana containing relatively little repetitive genomic DNA enabled the first chromosome painting in dicotyledonous plants. Here, we show for the first time chromosome painting in three different cytotypes of a monocotyledonous plant—the model grass, Brachypodium distachyon. Possible directions of further detailed studies are proposed, such as the evolution of grass karyotypes, the behaviour of meiotic chromosomes, and the analysis of chromosome distribution at interphase.

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Translocation (8;21) in acute nonlymphocytic leukemia delineated by chromosomal in situ suppression hybridization

Cited by 9 publications

References 16 publications

Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

Reinterpretation of G-banded complex karyotypes by fluorescence in situ hybridization with chromosome-specific DNA painting probes and alpha-satellite centromere-specific DNA probes in malignant hematological disorders

Analysis of genes and chromosomes by nonisotopic in situ hybridization

Painting the chromosomes of Brachypodium—current status and future prospects

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