Translocation of a globular polymer through a hairy pore

Constraints on Knot Insertion, Not Internal Jamming, Control Polycatenane Translocation Dynamics through Crystalline Pores

“…Additionally, the FENE bond potential (eq ) is defined up to a maximum value of 1.5σ, so both bond deformation and the pore microstructure can act to accommodate Hopf link translocation through the particularly small pores considered in this work. These pore sizes are smaller than those typically studied in the literature. ,,− , As such, we observe the emergence of atypical dynamics over the range of pore sizes that do not follow the archetypal power law behavior observed over sets of larger pore sizes.…”

“…Polymer translocation also has broad practical applications in biotechnology, spanning polymer characterization and separation, , gene therapy, DNA sequencing, , and controlled drug delivery . Since the pioneering works initiated the polymer translocation research field nearly three decades ago, , experimental research has been underpinned by a wide range of theoretical − and simulation-based studies. − …”

Mapping a single-molecule folding process onto a topological space

“…[7][8][9][10][11][12][13][14][15] How the molecules explore the topology landscape during folding and how the trajectory to the final topology is affected by external constraints are intriguing open questions. There are ubiquitous examples in nature and technology that macromolecules undergo drastic conformational changes under constraints, 16 including the translocation process of (bio)polymers through nanopores, [17][18][19][20][21] foldingunfolding transitions of globular proteins in shear flow [22][23][24] and constraining the chain ends by molecular chaperones and ribosomes. [25][26][27] In such processes, depending on the speed of the folding process, which can be considered as a measure of deviation from the equilibrium or quasi-equilibrium state, and geometrical constraints, the molecule undergoes different intermediate states before folding into its final state.…”

Drag Force for Asymmetrically Grafted Colloids in Polymer Solutions

“…They provide a basic structural element that can be used to produce useful nanoparticle clusters of different topologies through DNA-based self-assembly [33][34][35]. The concept of anisotropic viscosity might also be applicable for describing the transport of protein through the nuclear pore complex, where the transporting protein encounters heterogeneous polymer brush or gel like environment [36][37][38].…”