Translocation t(11; 14)(q 13;q32) in chronic lymphoid disorders

Abstract

The translocation t(11;14)(q13;q32) has been described in a spectrum of B-lymphoproliferative diseases and involves a putative oncogene, BCL1, which maps to chromosome band 11q13. Recent evidence indicates that this abnormality may delineate particular subtypes of lymphoma, such as intermediate lymphocytic and centrocytic lymphomas. Thus the possible significance of the t(11;14) within B-cell disorders should be reexamined in the light of a more objective approach to classifying these diseases by morphology, histology, and immunophenotype. We describe 16 patients with t(11;14)(q13;q32) from a series of 90 patients with chronic lymphoid disorders in whom clonal chromosome abnormalities were detected. All the cases were leukemic: prolymphocytic (B-PLL; 4/15 cases), chronic lymphocytic leukemia (CLL) with increase in prolymphocytes (2/9 cases), or non-Hodgkin lymphoma in leukemic phase, intermediate (3/4 cases), lymphoplasmacytic (2/2 cases), splenic lymphoma with villous lymphocytes (4/18 cases), and follicular (1 case). None of the CLL (25) or hairy cell leukemia cases (15) had t(11;14). Our findings showed that t(11;14) occurred in leukemias of mature B cells with lymphoplasmacytic features as judged by morphology and immunophenotype.

Small lymphocytic lymphoma, marginal zone B-cell lymphoma, and mantle cell lymphoma exhibit distinct gene-expression profiles allowing molecular diagnosis

“…[42][43][44] This feature is considered to be characteristic of MCL although it can also be seen in plasma-cell leukemia, multiple myeloma, hairy cell leukemias, and B-prolymphocytic leukemia, 45 and is missing in MCL. 7,46 We have demonstrated that the cyclin D1 signature was a feature independent from the MCL signature.…”

A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease

“…In the literature these cases have variously been called MCL, mantle cell leukemia, atypical CLL, PLL, and splenic lymphoma with villous lymphocytes (SLVL). [13][14][15][16][17] The basic question as to whether all cases with t(11;14) circulating lymphocytes are MCL variants or whether they encompass other diseases is unresolved.…”

FISH analysis for BCL-1 rearrangements and trisomy 12 helps the diagnosis of atypical B cell leukaemias

“…Follicular lymphoma carries the t(14;18)(q32;q21) in more than 80% of cases whilst 50-70% of mantle-cell lymphoma (MCL), [1][2][3][4][5] cases of splenic lymphoma with villous lymphocytes (SLVL) and lymphoplasmacytic lymphomas [6][7][8][9] have the t(11;14)(q13;q32) involving the IgH gene locus and the BCL1/cyclin D1 gene. In addition, few reports have suggested that t(11;14) is present in rare cases of atypical CLL although some of these patients have clinical and/or laboratory features of MCL.…”