Translocation t(11;14) (q13;q32) and Genomic Imbalances in Multi-Ethnic Multiple Myeloma Patients: A Malaysian Study

Ni, Ivyna Bong Pau; Ching, Ng Ching; Meng, Chang Kian; Zakaria, Zubaidah

doi:10.4081/hr.2012.e19

Cited by 13 publications

(6 citation statements)

References 38 publications

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“…To that end, we compared microarrayed samples of human cancers paired with their normal organ tissue samples. Using a public dataset of RNA profiles reported from 43 pairs of breast cancer and normal breast samples [ 32 ], we determined that approximately two-thirds of the breast cancers showed increased RPL24 transcript levels relative to their matched normal breast sample (Figure 1a ). The entire group of tumor samples exhibited a significant 20% mean overall increase in RPL24 expression levels (p = 0.001), indicating that transcriptional upregulation of RPL24 commonly occurs in human breast tumorigenesis (Figure 1b ).…”

Section: Resultsmentioning

confidence: 99%

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

et al. 2014

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Partial loss of large ribosomal subunit protein 24 (RPL24) function is known to protect mice against Akt or Myc-driven cancers, in part via translational inhibition of a subset of cap(eIF4E)-dependently translated mRNAs. The role of RPL24 in human malignancies is unknown. By analyzing a public dataset of matched human breast cancers and normal mammary tissue, we found that breast cancers express significantly more RPL24 than matched normal breast samples. Depletion of RPL24 in breast cancer cells by >70% reduced cell viability by 80% and decreased protein expression of the eIF4E-dependently translated proteins cyclin D1 (75%), survivin (46%) and NBS1 (30%) without altering GAPDH or beta-tubulin levels. RPL24 knockdown also reduced 80S subunit levels relative to 40S and 60S levels. These effects on expression of eIF4E-dependent proteins and ribosome assembly were mimicked by 2-24 h treatment with the pan-HDACi, trichostatin A (TSA), which induced acetylation of 15 different polysome-associated proteins including RPL24. Furthermore, HDAC6-selective inhibition or HDAC6 knockdown induced ribosomal protein acetylation. Via mass spectrometry, we found that 60S-associated, but not, polysome-associated, RPL24 undergoes HDACi-induced acetylation on K27. Thus, RPL24 K27 acetylation may play a role in ribosome assembly. These findings point toward a novel acetylation-dependent polysome assembly mechanism regulating tumorigenesis.

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Section: Resultsmentioning

confidence: 99%

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

et al. 2014

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“…The ATP8B4 gene can encode a P4-ATPase flippase complex, a member of the cation transport ATPase (P-type) family and type IV subfamily ( 27 ). Ni et al ( 27 ) suggested that ATP8B4 may be a potential prognostic marker and a therapeutic target in the treatment of patients with multiple myeloma who are B-Cell chronic lymphocytic lymphoma/small lymphocytic Lymphoma (BCL)-1/JHt(11;14)(q13;q32) translocation positive.…”

Section: Discussionmentioning

confidence: 99%

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

et al. 2018

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The aim of the present study was to investigate transient receptor potential cation channel subfamily M member 2 (TRPM2), a promising therapeutic target and biomarker for pancreatic ductal adenocarcinoma (PDAC) prognosis, in addition to determining its effects regarding tumor progression and invasion. PDAC is a fatal disease with a poor prognosis, and its associated pathogenic molecular mechanisms remain to be determined. In the present study, combined analysis using genomic and transcriptomic data from two PDAC studies was performed to discover a survival-associated biomarker of PDAC. Survival analysis for genes mutated in ≥10 patients was performed using a Kaplan-Meier curve and tested for significance using a log-rank test. Furthermore, gene-expression correlation analysis was performed to determine the genes with the strongest correlations to TRPM2. In addition, a Cell Counting Kit-8 assay, a scratch wound-healing assay and a Transwell assay were performed in the present study to investigate the proliferative, invasive and metastatic ability of PANC-1 cells in TRPM2-overexpressing and downregulated groups. The mutated TRPM2 gene had a strong negative correlation with patient survival probability compared with the normal control group (P=1.06×10-4). Expression of TRPM2 was strongly correlated with expression of probable phospholipid-transporting ATPase IM, γ-parvin, tudor domain containing 9, Toll-like receptor 7 and Scm-like with four MBT domains protein 2 according to the criterion of a correlation coefficient >0.5. Furthermore, the results of the present study demonstrated that the TRPM2 overexpression in a PDAC cell line (PANC-1) promoted cell proliferation, invasion and metastatic ability. TRPM2 represents a potential therapeutic target and prognostic marker for patients with PDAC. TRPM2 regulates cell proliferation, invasion and migration; however, the underlying mechanism requires further investigation in future studies.

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“…It is frequently associated with genetic abnormalities such as chromosomal loss and translocation events 75,76 . In a Malaysian study in 2012, SLy2 was identified as a gene located within a chromosomal aberration region in 105 MM patients 77 . Subsequently, Amend and colleagues reported a large chromosome deletion in MM patients affecting the complete SLy2 ‐coding gene section and probably leading to a total loss of SLy2 78 .…”

Section: Sly2mentioning

confidence: 99%

The emerging and diverse roles of the SLy/SASH1‐protein family in health and disease—Overview of three multifunctional proteins

et al. 2021

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Translocation t(11;14) (q13;q32) and Genomic Imbalances in Multi-Ethnic Multiple Myeloma Patients: A Malaysian Study

Cited by 13 publications

References 38 publications

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth

TRPM2 promotes the proliferation and invasion of pancreatic ductal adenocarcinoma

The emerging and diverse roles of the SLy/SASH1‐protein family in health and disease—Overview of three multifunctional proteins

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