Translocation t(8;14)(q24;q32) and del(1)(p22) in FAB-L1 adult acute lymphoblastic leukemia with long survival

Carbone, P.; Barbata, G; Tumminello, P.; Bellanca, F.; Majolino, Ignazio; Granata, G

doi:10.1016/0165-4608(88)90321-4

Cited by 5 publications

(1 citation statement)

References 22 publications

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“…Carbone et al (1988), for example, described a patient with acute lymphoblastic leukemia and a del This YAC also contains D1S3649 which is known to lie above the 1p22 breakpoint and is on the same 150 Kb fragment which contains the NotI site. The location of D1S424 which is a reference marker on the chromosome 1 linkage map (Gyapay et al, 1994) is also indicated Figure 2 Analysis of the cosmid contig containing the G®-1 gene.…”

mentioning

confidence: 99%

Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22

Roberts

Cowell

1997

Oncogene

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mentioning

confidence: 99%

Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22

Roberts

Cowell

1997

Oncogene

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Acute Lymphoblastic Leukemia, FAB-L3, with t(8;14) and Precursor B Cell Immunophenotype: Case Report and Literature Review

Voytek¹,

Rezuke²,

Benn³

et al. 1995

Journal of Histotechnology

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New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group report of 343 cases

Schneider

Carroll

Shuster

et al. 2000

Blood

109

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To further define the cytogenetic differences between B-cell lineage (B-lineage) acute lymphoblastic leukemia (ALL) and T-cell lineage ALL (T-ALL) and to determine the prognostic value of cytogenetics in childhood T-ALL, the blast cell karyotypes of 343 cases of pediatric T-ALL, the largest series reported to date, were evaluated. Cytogenetics were performed in a single central laboratory, and the children were treated using a single Pediatric Oncology Group protocol. Clear differences between the karyotypic characteristics of B-lineage ALL and T-ALL were confirmed. This study suggests that there may be survival differences associated with some T-ALL blast cell karyotypes. Better survival is associated with only normal karyotypes and with t(10;14) (translocation of chromosomes 10 and 14); worse survival is associated with the presence of any derivative chromosome. Two new recurring chromosome aberrations previously not reported in T-ALL were found: del(1)(p22) and t(8;12)(q13;p13). Ten aberrations found in this series, which were reported only once previously in T-ALL, can now be considered recurring abnormalities in T-ALL. All 12 of these new recurring aberrations are targets for discovery and characterization of new genes that are important in T-cell development and leukemogenesis.

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Translocation t(8;14)(q24;q32) and del(1)(p22) in FAB-L1 adult acute lymphoblastic leukemia with long survival

Cited by 5 publications

References 22 publications

Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22

Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22

Acute Lymphoblastic Leukemia, FAB-L3, with t(8;14) and Precursor B Cell Immunophenotype: Case Report and Literature Review

New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group report of 343 cases

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