Translocation t(8;16)(p11;p13) in acute nonlymphoblastic leukemia (M4) possibly secondary to Hodgkin's disease

Translocation t(8;16)(p11;p13) in neonatal acute monocytic leukaemia

“…On the other hand, t(8;16)(pll;p13) may be specifically linked to the differentiated AMoL subtype (M5b) with active haemophagocytosis by leukaemic cells [7]. Nineteen cases of acute non-lymphocytic leukaemia (ANLL) with t(8;16)(p11;p13) have been reported [2,3,[5][6][7][8][9]. Seven cases occurred in childhood and 18 cases are of monocytic lineage (M4 6 cases, M5a 6 cases, M5b 5 cases and M5 without subtype 1 case).…”

RT-PCR analysis of theMOZ-CBP andCBP-MOZ chimeric transcripts in acute myeloid leukemias with t(8;16)(p11;p13)

“…Only a few reported patients, however, have undergone bone marrow transplantation, and it remains to be seen whether this treatment modality may modify the disease outcome. Among the 40 patients with t(8;16)-positive AML (Mitelman, 1998;present study), nine (23%) had been exposed to chemotherapy (CT) or irradiation (Lai et al, 1987;Brookwell and Hunt, 1988;Barbata et al, 1989;Quesnel et al, 1993;Demuynck et al, 1995;Savasan et al, 1996;Michallet et al, 1998;present Case 1). Most patients with therapy-related AML (t-AML) and t(8;16) had received CT including an anthracycline (Quesnel et al, 1993;Michallet et al, 1998), as was also the case for our Patient 1 who developed AML less than one year after ABVD treatment, that includes doxorubicin, for Hodgkin's disease.…”

3p21 is a recurrent treatment-related breakpoint in myelodysplastic syndrome and acute myeloid leukemia

“…The biological significance of this unusual anomaly associated with 3p21 is unclear, but it may be a treatment-related chromosomal abnormality. Abnormalities which involve chromosome region 16p 13 were also detected in other cases of secondary malignant hematological diseases (Whang-Peng et al 1988;Barbata et al, 1989;Pui et al" 1989).…”