Translocation (X;1)(p11.2;q21)

Meloni, Aurelia M.; Sandberg, Avery A.; Pontes, J. Edson; Dobbs, Robert M.

doi:10.1016/0165-4608(92)90388-o

Cited by 17 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 about papillary RCC showing rearrangement of the critical 3p segment, at least at a molecular level [33,34], Several hum an renal cell carcinomas with X;autosome translocations have been reported in recent years (see for review [35]], The t(X;l)(pll.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translo cation form a distinct subgroup of chromophilic RCC, showing clear cell features. These tumors preferentially occur in male patients [36][37][38][39], although one female case has recently been described [40].…”

Section: Classification Of Renal Cell Cancermentioning

confidence: 99%

Cytogenetic classification of renal cell cancer

Berg¹,

Dijkhuizen²,

Oosterhuis

et al. 1997

Cancer Genetics and Cytogenetics

View full text Add to dashboard Cite

Section: Classification Of Renal Cell Cancermentioning

confidence: 99%

Cytogenetic classification of renal cell cancer

Berg¹,

Dijkhuizen²,

Oosterhuis

et al. 1997

Cancer Genetics and Cytogenetics

View full text Add to dashboard Cite

Section: Prcc-tfe3mentioning

confidence: 99%

“…As cloning and molecular strategies improved in the early 1999's, another recurrent gene fusion would soon be described in papillary renal cell carcinoma (PRCC), the second most common carcinoma of the renal tubules accounting for 15-20% of all renal cell carcinomas [62][63][64][65][66]. Karyotypic analysis as early as 1986 (de Jong et al) led to the identification of abnormalities in the Xp11.2 region characterized by a genomic rearrangement, t(X;1)(p11.2;q21.2) [62][63][64][65][66]. Interestingly, before any of the genes surrounding the breakpoint were cloned a gene encoding TFE3, which was originally identified by their ability to bind to μE3 elements in the immunoglobin heavy chain intronic enhancer [67], was mapped to the Xp11.22 locus [68], and later shown to encode a member of the basic helix-loop-helix followed by a leucine zipper family (bHLHzip) of transcription factors.…”

Section: Prcc-tfe3mentioning

confidence: 99%

Dissecting the Molecular Mechanism of RhoC GTPase Expression in the Normal and Malignant Breast

Brenner¹

2011

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

show abstract

Renal cell carcinoma with X;1 translocation in a child with Klinefelter syndrome

et al. 1998

View full text Add to dashboard Cite

Klinefelter syndrome (KS) is a sex chromosome abnormality occurring in 1 in 1,000 males. An association with leukemia, germ cell tumor, and male breast cancer has been suggested in KS. Such information is important for professionals caring for KS patients as the condition is frequently not clinically recognizable until after puberty. We report on a renal cell carcinoma (RCC) in a 10-year-old boy with KS. He developed intermittent hematuria at age 10 years and was diagnosed with a right kidney mass, which on pathology was identified as RCC. In addition, he was known to have learning disabilities and language delays. Analysis of peripheral blood chromosomes showed a 47,XXY karyotype while analysis of tumor cells demonstrated clonal abnormalities including a translocation between chromosomes X and 1, designated 47,XXYc,t(X;1)(p11.2;q21)[6]/47,XXYc,t(X;1),r(Xp)[2]/46,X XYc,-X,t(X;1)[7]. Renal cell carcinoma is rare in childhood and is not previously reported in KS. The oncogenetic significance of the chromosomal regions involved in this translocation is discussed in relation to the congenital abnormality of the patient.

show abstract

Translocation (X;1)(p11.2;q21)

Cited by 17 publications

References 6 publications

Cytogenetic classification of renal cell cancer

Cytogenetic classification of renal cell cancer

Dissecting the Molecular Mechanism of RhoC GTPase Expression in the Normal and Malignant Breast

Renal cell carcinoma with X;1 translocation in a child with Klinefelter syndrome

Contact Info

Product

Resources

About