Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

Boerma, Evert-Jan G.; Siebert, Reiner; Kluin, Philippus; Baudis, Michael

doi:10.1038/leu.2008.281

Cited by 186 publications

(130 citation statements)

References 52 publications

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“…We found that Burkitt lymphoma cases had low number of additional cytogenetic abnormalities (mean of 1.7), compared with unclassifiable (3.3) and diffuse large B-cell lymphomas (21.7), which is also in agreement with the recent observations that approximately 80% of Burkitt lymphoma cases have a simple karyotype with a low cytogenetic imbalance complexity score of 0-2. 23 Furthermore, using the cut-off of two additional cytogenetic abnormalities, we found that there were a number of significant differences between the patients with simple (group I) versus complex (group II) karyotypes. Notably, group I cases were more likely to have a diagnosis of Burkitt lymphoma and express bcl-6.…”

Section: Discussionmentioning

confidence: 85%

“…Although pediatric and adult Burkitt lymphoma cases have some differences in morphology and immunophenotype, 3,4 from a genomic complexity and gene expression point of view, Burkitt lymphoma in children and adults is the same disease. 13,14,23,30,31 It should also be noted that our study focused on MYC-IG rearrangement. Future studies should include non-IG partner genes to comprehensively assess the spectrum of MYC-rearranged lymphomas.…”

Section: Discussionmentioning

confidence: 99%

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Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

et al. 2010

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Rearrangement of MYC with immunoglobulin genes is a hallmark of Burkitt lymphoma. However, this rearrangement is not entirely specific and is often accompanied by varying numbers of additional cytogenetic abnormalities. This study aimed to assess the impact of karyotypic complexity, in correlation with comprehensive immunophenotypic analyses on the diagnosis and clinical outcomes of 34 cases of MYC-IG rearranged lymphomas that included Burkitt lymphoma (twenty-two cases), diffuse large B-cell lymphoma (three cases), unclassifiable B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (six cases), and plasmablastic lymphoma (three cases). Additional cytogenetic abnormalities were observed in 26 of 34 cases (76%), including four cases (12%) that harbored dual translocations involving BCL-2 or BCl-6. Burkitt lymphoma cases had a significantly lower number of additional abnormalities (mean of 1.7), compared with unclassified B-cell lymphoma (3.3), diffuse large B-cell lymphoma (21.7), and plasmablastic lymphoma (6.7). Cases with simple karyotype (p2 additional abnormalities) were more likely to have a diagnosis of Burkitt lymphoma (89 versus 33% in patients with 42 additional abnormalities, Po0.01) and express bcl-6 (95 versus 47%, Po0.01). In addition, Burkitt lymphoma, bcl-6 expression, and simple karyotype were individual predictors of better overall survival. However, in multivariate analyses, only bcl-6 expression remained an independent predictor, although survival could be further stratified by karyotypic complexity in bcl-6( þ ) patients. We conclude that simple karyotype and bcl-6 expression suggest a diagnosis of Burkitt lymphoma and may portend better overall survival. These results may be very useful in the diagnosis and stratification of MYC-IG rearranged high-grade B-cell lymphomas.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

et al. 2010

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“…A relatively resolution-independent surrogate marker of genomic instability, CNA complexity, was determined for each case by evaluating the occurrence of gain and loss events per chromosome arm, with a maximum score of 2 per arm (i.e. occurrence of one or more of each gain and loss; modified from [27]). …”

Section: Exploratory Data Mining and Statistical Analysismentioning

confidence: 99%

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

Bueren

Gerß²,

Hagel

et al. 2012

J Neurooncol

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Little is known about frequency, association with clinical characteristics, and prognostic impact of DNA copy number alterations (CNA) on survival in central primitive neuroectodermal tumors (CNS-PNET) and tumors of the pineal region. Searches of MEDLINE, Pubmed, and EMBASE-after the original description of comparative genomic hybridization in 1992 and July 2010-identified 15 case series of patients with CNS-PNET and tumors of the pineal region whose tumors were investigated for genomewide CNA. One additional case study was identified from contact with experts. Individual patient data were extracted from publications or obtained from investigators, and CNAs were converted to a digitized format suitable for data mining and subgroup identification. Summary profiles for genomic imbalances were generated from case-specific data. Overall survival (OS) was estimated using the Kaplan-Meier method, and by univariable and multivariable Cox regression models. In their overall CNA profiles, low grade tumors of the pineal region clearly diverged from CNS-PNET and pineoblastoma. At a median follow-up of 89 months, 7-year OS rates of CNS-PNET, pineoblastoma, and low grade tumors of the pineal region were 22.9 ± 6, 0 ± 0, and 87.5 ± 12 %, respectively. Multivariable analysis revealed that histology (CNS-PNET), age (2.5 years), and possibly recurrent CNAs were associated with unfavorable OS. DNA copy number profiling suggests a close relationship between CNS-PNET and pineoblastoma. Low grade tumors of the pineal region differed from CNS-PNET and pineoblastoma. Due to their high biological and clinical variability, a coordinated prospective validation in future studies is necessary to establish robust risk factors. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 -3 - AbstractLittle is known about frequency, association with clinical characteristics, and prognostic impact of DNA copy number alterations (CNA) on survival in central primitive neuroectodermal tumors (CNS-PNET) and tumors of the pineal region.Searches of MEDLINE, Pubmed, and EMBASE -after the original description of comparative genomic hybridization and July 2010 -identified 15 case series of patients with CNS-PNET and tumors of the pineal region whose tumors were investigated for genome-wide CNA. One additional case study was identified from contact with experts. Individual patient data were extracted from publications or obtained from investigators, and CNAs were converted to a digitized format suitable for data mining and subgroup identification. Summary profiles for genomic imbalances were generated from case specific data. Overall survival (OS) was estimated using Kaplan-Meier method, by univariable, and multivariable Cox regression models. In their overall CNA profiles, low grade tumors of the pineal region clearly diverged from CNS-PNET and pineoblas...

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“…According to a report by Tomita et al, DHL has an extremely poor prognosis, with a median survival time of approximately 6 months and 1-year survival rate of 22 % [7]. In the majority of cases, it is at an advanced stage at diagnosis, with bone marrow and central nervous system infiltration, with some reports suggesting that these patients have elevated serum LDH levels and are resistant to chemotherapy [8], and others suggesting a poor prognosis [9,24].…”

Section: Discussionmentioning

confidence: 99%

A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature

Sekiguchi

Shimada

Imai

et al. 2014

Indian J Hematol Blood Transfus

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Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

Cited by 186 publications

References 52 publications

Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

A Case of Advanced Primary Thyroid Double-Hit B Cell Lymphoma in Which Complete Remission has been Maintained After High-Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation Performed During the Second Remission, with a Review of the Literature

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