Transluminal extraction catheter for acute myocardial infarction

Topaz, On; Miller, Greg; Vetrovec, George W.

doi:10.1002/(sici)1097-0304(199703)40:3<291::aid-ccd17>3.0.co;2-s

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…Repeat bypass operation is associated with a relatively high operative risk [2], and urokinase infusion [3] is cumbersome, causing frustration among patients and physicians alike, while standard balloon angioplasty achieves less than desirable results. TEC atherectomy has been described as a successful, alternative mechanical technique for recanalization of degenerative saphenous vein grafts [4][5][6][7][8], with angioscopy studies reporting complete or partial thrombus removal in 75%-100% of thrombotic lesions following TEC [9,10].…”

Section: Discussionmentioning

confidence: 99%

Acute thrombotic-ischemic coronary syndromes: The usefulness of TEC

Topaz

Bernardo

Desai

et al. 1999

Cathet. Cardiovasc. Intervent.

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Section: Discussionmentioning

confidence: 99%

Acute thrombotic-ischemic coronary syndromes: The usefulness of TEC

Topaz

Bernardo

Desai

et al. 1999

Cathet. Cardiovasc. Intervent.

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“…Previous studies have also demonstrated that effective thrombolysis could be achieved using either local infusion of urokinase [6,21] of ultrasound-mediated thrombolytic therapy [25][26][27][28]. A mechanical technique has been applied successfully in acute myocardial infarction and ischemic, thrombotic syndromes [29]. However, these techniques may not be feasible in many clinical situations where small vessels are involved, e.g., stroke treatment, due to the stiffness and relatively larger size of the catheters.…”

Section: Discussionmentioning

confidence: 99%

Enhanced laser thrombolysis with photomechanical drug delivery: An in vitro study

et al. 1998

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Background and Objective: Current techniques for laser thrombolysis are limited because they can not completely clear thrombotic occlusions in arteries, typically leaving residual thrombus on the walls of the artery. The objective of this study was to investigate the possibility of using photomechanical drug delivery to enhance laser thrombolysis by delivering drugs into mural thrombus during laser thrombolysis. Study Design/Materials and Methods: Three experimental protocols were performed in vitro to quantitatively compare the effectiveness of thrombolysis by 1) constant infusion of drug, 2) laser thrombolysis, and 3) photomechanical drug delivery. A fiber‐optic flushing catheter delivered drug (a solution of 1 μm fluorescent microspheres) and light ( a 1 μs pulsed dye laser) into a gelatin‐based thrombus model. The process of laser‐thrombus interaction was visualized using flash photography and the laser‐induced pressure waves were measured using an acoustic transducer. Results Lumen sizes generated by mechanically manipulating the catheter through the thrombus were smaller than those generated by laser ablation. The microspheres could be driven several hundred microns into the mural thrombus. Conclusion Photomechanical drug delivery has potential for enhancement of laser thrombolysis. Two mechanisms seem to be involved in photomechanical drug delivery: 1) mural deposition of the drug at the ablation site and 2) increased exposure of the thrombus surface area to the drug. Lasers Surg. Med. 23:151–160, 1998. © 1998 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Enhanced laser thrombolysis with photomechanical drug delivery: An in vitro study

et al. 1998

View full text Add to dashboard Cite

Background and Objective: Current techniques for laser thrombolysis are limited because they can not completely clear thrombotic occlusions in arteries, typically leaving residual thrombus on the walls of the artery. The objective of this study was to investigate the possibility of using photomechanical drug delivery to enhance laser thrombolysis by delivering drugs into mural thrombus during laser thrombolysis. Study Design/Materials and Methods: Three experimental protocols were performed in vitro to quantitatively compare the effectiveness of thrombolysis by 1) constant infusion of drug, 2) laser thrombolysis, and 3) photomechanical drug delivery. A fiber-optic flushing catheter delivered drug (a solution of 1 m fluorescent microspheres) and light ( a 1 s pulsed dye laser) into a gelatin-based thrombus model. The process of laserthrombus interaction was visualized using flash photography and the laser-induced pressure waves were measured using an acoustic transducer. Results: Lumen sizes generated by mechanically manipulating the catheter through the thrombus were smaller than those generated by laser ablation. The microspheres could be driven several hundred microns into the mural thrombus. Conclusion: Photomechanical drug delivery has potential for enhancement of laser thrombolysis. Two mechanisms seem to be involved in photomechanical drug delivery: 1) mural deposition of the drug at the ablation site and 2) increased exposure of the thrombus surface area to the drug. Lasers Surg. Med. 23: 151-160, 1998.

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Transluminal extraction catheter for acute myocardial infarction

Cited by 8 publications

References 26 publications

Acute thrombotic-ischemic coronary syndromes: The usefulness of TEC

Acute thrombotic-ischemic coronary syndromes: The usefulness of TEC

Enhanced laser thrombolysis with photomechanical drug delivery: An in vitro study

Enhanced laser thrombolysis with photomechanical drug delivery: An in vitro study

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