Transmammary-delivered meloxicam in piglets undergoing castration and tail docking: impact on pharmacokinetics and pain biomarkers

Bates, Jessica L.

doi:10.31274/etd-180810-4341

Cited by 1 publication

(2 citation statements)

References 21 publications

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“…Sows were administered 30 mg/kg meloxicam orally for 3 days to evaluate whether analgesic concentrations could be delivered to their offspring via milk. Button ulcers and gastritis were identified in 2/5 sows and their litters [16].…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle

Fritz

Ensley

Lawrence

et al. 2023

Veterinary Sciences

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Adverse effects associated with overdose of NSAIDs are rarely reported in cattle, and the risk level is unknown. If high doses of NSAIDs can be safely administered to cattle, this may provide a longer duration of analgesia than using current doses where repeated administration is not practical. Meloxicam was administered to 5 mid-lactation Holstein dairy cows orally at 30 mg/kg, which is 30 times higher than the recommended 1 mg/kg oral dose. Plasma and milk meloxicam concentrations were determined using high-pressure liquid chromatography with mass spectroscopy (HPLC-MS). Pharmacokinetic analysis was performed by using noncompartmental analysis. The geometric mean maximum plasma concentration (Cmax) was 91.06 µg/mL at 19.71 h (Tmax), and the terminal elimination half-life (T1/2) was 13.79 h. The geometric mean maximum milk concentration was 33.43 µg/mL at 23.74 h, with a terminal elimination half-life of 12.23 h. A thorough investigation into the potential adverse effects of a meloxicam overdose was performed, with no significant abnormalities reported. The cows were humanely euthanized at 10 d after the treatment, and no gross or histologic lesions were identified. As expected, significantly higher plasma and milk concentrations were attained after the administration of 30 mg/kg meloxicam with similar half-lives to previously published reports. However, no identifiable adverse effects were observed with a drug dose 30 times greater than the industry uses within 10 days of treatment. More research is needed to determine the tissue withdrawal period, safety, and efficacy of meloxicam after a dose of this magnitude in dairy cattle.

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Section: Discussionmentioning

confidence: 99%

“…Sows were administered 30 mg/kg meloxicam per os for 3 consecutive days in an attempt to deliver adequate meloxicam for analgesia in milk to their offspring [16]. Minor lesions in the gastrointestinal tract were noted at necropsy in some animals, but this dose was well-tolerated clinically.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle

Fritz

Ensley

Lawrence

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

show abstract

Transmammary-delivered meloxicam in piglets undergoing castration and tail docking: impact on pharmacokinetics and pain biomarkers

Abstract: This thesis is dedicated to my parents, Kent and Marla Bates. Without their unwavering support, guidance, and encouragement towards education, I wouldn't be the person and the veterinarian that I am today. .

Cited by 1 publication

References 21 publications

Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle

Pharmacokinetics, Milk Residues, and Toxicological Evaluation of a Single High Dose of Meloxicam Administered at 30 mg/kg per os to Lactating Dairy Cattle

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