Transmetallation of Gd-DTPA by Fe3+, Cu2+ and Zn2+ in water: Batch experiments and coagulation–flocculation simulations

Rabiet, Marion; Letouzet, Marine; Hassanzadeh, Sepideh; Simon, Stéphane

doi:10.1016/j.chemosphere.2013.09.102

Cited by 24 publications

(16 citation statements)

References 24 publications

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“…One major challenge in the development of a Gd-based contrast agent is the inherent toxicity of the Gd 3+ ion when dissociated from its chelate in vivo. (Zhou and Lu 2013) In the nanocrystal form (i.e., NaGdF 4 ), the hexagonal phase provides a stable matrix that eliminates transmetallation with endogenous metal ions (i.e., Cu 2+ , Zn 2+ , Fe 2+ /Fe 3+ ) (Morcos 2008;Rabiet et al 2014;Telgmann et al 2012;Wu et al 2010) and hinders any leaching of toxic, free Gd 3+ ions. (Chen et al 2011;Kumar et al 2009) The very low concentration of Gd 3+ when dialyzed against H 2 O demonstrates the high stability of the nanoparticles against dissolution attributed to their thermodynamically stable hexagonal phase.…”

Section: Discussionmentioning

confidence: 99%

Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization

et al. 2021

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Background In this study, we report on the synthesis, imaging, and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided that the nanoparticles are taken up intracellularly. Results Our ultrasmall β-NaGdF4:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohexol. A 2 Gy dose of X-ray induced ~ 20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~ 60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS. Conclusion These biocompatible and in vivo clearable ultrasmall NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications.

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Section: Discussionmentioning

confidence: 99%

Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization

et al. 2021

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“…One major challenge in the development of a Gd-based contrast agent is the inherent toxicity of the Gd 3+ ion when dissociated from its chelate in vivo. [57] In the nanocrystal form (i.e., NaGdF 4 ), the hexagonal phase provides a stable matrix that eliminates transmetallation with endogenous metal ions (i.e., Cu 2+ , Zn 2+ , Fe 2+ /Fe 3+ ) [58][59][60][61] and hinders any leaching of toxic,free Gd 3+ ions. [62,63] The very low concentration of Gd 3+ when dialyzed against H 2 O demonstrates the high stability of the nanoparticles against dissolution attributed to their thermodynamically stable hexagonal phase.…”

Section: Discussionmentioning

confidence: 99%

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

Damasco

Ohulchanskyy

Mahajan

et al. 2021

Preprint

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Background: In this study, we report on the synthesis, imaging and radiosensitizing properties of ultrasmall β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided the nanoparticles are taken up intracellularly.Results: Our ultrasmall β-NaGdF4:Yb50% nanoparticles demonstrate improvement in T1-weighted contrast over the standard clinical MR imaging agent Gd-DTPA and similar CT signal enhancement capabilities as commercial agent iohexol. A 2 Gy dose of X-ray induced ~20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS.Conclusion: These biocompatible and in vivo clearable ultra-small NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications.

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“…One major challenge in the development of a Gd-based contrast agent is the inherent toxicity of the Gd 3+ ion when dissociated from its chelate in vivo. [53] In the nanocrystal form (i.e., NaGdF 4 ), the hexagonal phase provides a stable matrix that eliminates transmetallation with endogenous metal ions (i.e., Cu 2+ , Zn 2+ , Fe 2+ /Fe 3+ ) [54][55][56][57] and hinders any leaching of toxic free Gd 3+ ions. [58,59] The very low concentration of Gd 3+ when dialyzed against H 2 O demonstrates the high stability of the nanoparticles against dissolution attributed to their thermodynamically stable hexagonal phase.…”

Section: Discussionmentioning

confidence: 99%

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

Damasco

Ohulchanskyy

Mahajan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background In this study, we report on the synthesis, imaging properties and radiosensitizing properties of β-NaGdF4:Yb50% nanoparticles as a multifunctional theranostic platform. The synthesized nanoparticles act as potent bimodal contrast agents with superior imaging properties compared to existing agents used for magnetic resonance imaging (MRI) and computed tomography (CT). Clonogenic assays demonstrated that these nanoparticles can act as effective radiosensitizers, provided the nanoparticles are taken up intracellularly. Results A 2 Gy dose of X-ray induced ~ 20% decrease in colony survival when C6 rat glial cells were incubated with non-targeted nanoparticles (NaGdF4:Yb50%), whereas the same X-ray dose resulted in a ~ 60% decrease in colony survival with targeted nanoparticles conjugated to folic acid (NaGdF4:Yb50%-FA). Intravenous administration of nanoparticles resulted in clearance through urine and feces within a short duration, based on the ex vivo analysis of Gd3+ ions via ICP-MS. Conclusion These biocompatible and in vivo clearable ultra-small NaGdF4:Yb50% are promising candidates for further evaluation in image-guided radiotherapy applications.

show abstract

Transmetallation of Gd-DTPA by Fe3+, Cu2+ and Zn2+ in water: Batch experiments and coagulation–flocculation simulations

Cited by 24 publications

References 24 publications

Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization

Excretable, ultrasmall hexagonal NaGdF4:Yb50% nanoparticles for bimodal imaging and radiosensitization

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

Excretable, ultrasmall hexagonal NaGdF4:Yb50% Nanoparticles for bimodal imaging and radiosensitization

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