Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets

Yen, H; Forrest, H. S.; Cheung, Peter Pak-Hang; Wong, Daniel; Li, O; Krauss, Scott; Ferguson, Angela; Crumpton, JC; Jones, Jeremy C.; Choy, Tsj; Ma, Eric; Poon, LL; Smith, GJ; Nicholls, JM; Guan, Yi; Rg, Webster; Webby, Richard J.; Peiris, J S Malik

doi:10.1186/1753-6561-5-s1-p11

Cited by 4 publications

(5 citation statements)

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“…However, human H1v viruses were also shown to successfully infect and transmit between ferrets (Pulit-Penaloza et al 2018a,b, 2019a. Moreover, some swine IAV have been shown to infect and transmit among ferrets without evidence of human zoonosis (Yen et al 2011;Zhu et al 2011;Pascua et al 2012Pascua et al , 2013. The ferret transmission model appears to be a rather liberal litmus test for indicating potential for human infection by swine IAV or an indication that many of the globally circulating swine virus lineages are capable of such infection.…”

Section: Risk Of Contemporary Swine Iav For Humansmentioning

confidence: 99%

Swine Influenza A Viruses and the Tangled Relationship with Humans

Anderson

Chang

Arendsee

et al. 2020

Cold Spring Harb Perspect Med

136

122

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Influenza A viruses (IAVs) are the causative agents of one of the most important viral respiratory diseases in pigs and humans. Human and swine IAV are prone to interspecies transmission, leading to regular incursions from human to pig and vice versa. This bidirectional transmission of IAV has heavily influenced the evolutionary history of IAV in both species. Transmission of distinct human seasonal lineages to pigs, followed by sustained within-host transmission and rapid adaptation and evolution, represent a considerable challenge for pig health and production. Consequently, although only subtypes of H1N1, H1N2, and H3N2 are endemic in swine around the world, extensive diversity can be found in the hemagglutinin (HA) and neuraminidase (NA) genes, as well as the remaining six genes. We review the complicated global epidemiology of IAV in swine and the inextricably entangled implications for public health and influenza pandemic planning.

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Section: Risk Of Contemporary Swine Iav For Humansmentioning

confidence: 99%

Swine Influenza A Viruses and the Tangled Relationship with Humans

Anderson

Chang

Arendsee

et al. 2020

Cold Spring Harb Perspect Med

136

122

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“…More recently, an ‘avian‐like’ H1N1 influenza virus was shown to transmit through four pairs of vaccinated pigs at antibody levels thought to protect against infection (Lloyd et al., 2011). Influenza viruses isolated from pigs were also able to transmit efficiently via direct contact in a ferret model (Yen et al., 2011). Influenza virus transmission was recently quantified in non‐vaccinated and vaccinated pig populations with a reproduction ratio estimate of 10.66 in non‐vaccinated pigs and reproduction ratio estimates of 1 and 0 for pigs vaccinated with heterologous and homologous inactivated vaccines (Romagosa et al., 2011).…”

Section: Influenza Virus Transmission In Pigsmentioning

confidence: 99%

Transmission of Influenza A Virus in Pigs

Torremorell

Allerson

Corzo

et al. 2012

Transboundary and Emerging Diseases

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Summary Influenza A virus infections cause respiratory disease in pigs and are a risk to public health. The pig plays an important role in influenza ecology because of its ability to support replication of influenza viruses from avian, swine and human species. Influenza A virus is widespread in pigs worldwide, and influenza A virus interspecies transmission has been documented in many events. Influenza A virus is mostly transmitted through direct pig‐to‐pig contact and aerosols although other indirect routes of transmission may also exist. Several factors contribute to differences in the transmission dynamics within populations including among others vaccination, pig flow, animal movement and animal introduction which highlights the complexity of influenza A transmission in pigs. In addition, pigs can serve as a reservoir of influenza A viruses for other pigs and other species and understanding mechanisms of transmission within pigs and from pigs to other species and vice versa is crucial. In this paper, we review the current understanding of influenza virus transmission in pigs. We highlight the ubiquity of influenza A virus in the pig population and the widespread distribution of pandemic H1N1 virus worldwide while emphasizing an understanding of the routes of transmission and factors that contribute to virus spread and dissemination within and between pig populations. In addition, we describe transmission events between pigs and other species including people. Understanding transmission is crucial for designing effective control strategies and for making well‐informed recommendations for surveillance.

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“…72 If the new reassortments result in increased transmission, virulence, or immune escape, they may cause a massive threat to humans and public health by potential generation of a new pandemic influenza virus. 57,75 Not much is known about the association between genetic diversity and pathogenicity during SARS-CoV-2 outbreaks in animals. Whole-genome sequencing analysis in SARS-CoV-2infected mink revealed high genetic diversity in farms which tested negative before, suggesting a fast evolution of viruses in the mink populations.…”

Section: Host Species Barriersmentioning

confidence: 99%

Section: Host Species Barriersmentioning

confidence: 99%

Reverse Zoonosis of COVID-19: Lessons From the 2009 Influenza Pandemic

Ayudhya

Kuiken

2020

Vet Pathol

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Over the past decade, pandemics caused by pandemic H1N1 (pH1N1) influenza virus in 2009 and severe acute respiratory syndrome virus type 2 (SARS-CoV-2) in 2019 have emerged. Both are high-impact respiratory pathogens originating from animals. Their wide distribution in the human population subsequently results in an increased risk of human-to-animal transmission: reverse zoonosis. Although there have only been rare reports of reverse zoonosis events associated with the ongoing coronavirus disease 2019 (COVID-19) pandemic from SARS-CoV-2 so far, comparison with the pH1N1 influenza pandemic can provide a better understanding of the possible consequences of such events for public and animal health. The results of our review suggest that similar factors contribute to successful crossing of the host species barriers in both pandemics. Specific risk factors include sufficient interaction between infected humans and recipient animals, suitability of the animal host factors for productive virus infection, and suitability of the animal host population for viral persistence. Of particular concern is virus spread to susceptible animal species, in which group housing and contact network structure could potentially result in an alternative virus reservoir, from which reintroduction into humans can take place. Virus exposure in high-density populations could allow sustained transmission in susceptible animal species. Identification of the risk factors and serological surveillance in SARS-CoV-2-susceptible animal species that are group-housed should help reduce the threat from reverse zoonosis of COVID-19.

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Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets

Cited by 4 publications

References 0 publications

Swine Influenza A Viruses and the Tangled Relationship with Humans

Swine Influenza A Viruses and the Tangled Relationship with Humans

Transmission of Influenza A Virus in Pigs

Reverse Zoonosis of COVID-19: Lessons From the 2009 Influenza Pandemic

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