Transmission dynamics of Trichomonas vaginalis and HIV/AIDS coinfection

Bhunu, C. P.; Mushayabasa, Steady

doi:10.1016/j.hivar.2015.05.005

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…These observations would suggest and that STIs, particularly T. vaginalis, may constitute a significant risk factor for HIV susceptibility in women. The preponderance of T. vaginalis infection among HIV seropositives is particularly interesting in many instances [12], as other studies have noted that T. vaginalis infection may expand the portal of entry for HIV in exposed individuals, thus facilitating HIV transmission and increasing HIV shedding [13,14]. Investigators have reported that wet mount procedure that is often used for T. vaginalis screening seems to have a low sensitivity of about 70%.…”

Section: Discussionmentioning

confidence: 99%

Coinfections of Human Immunodeficiency Virus and Sexually Transmitted Infections among HIV Seropositive Pregnant Women at Healthcare Centres in Akure, Southwestern Nigeria

Kassim

2016

Int Arch Med

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Background: Sexually transmitted infections (STIs) represent significant risk factors for HIV transmission and adverse fetal complications in pregnancy. We tested 240 pregnant women for their HIV serostatus and for the effects of HIV-STI coinfections on CD4+ cell counts and on HIV plasma viral load. The study was conducted at four antenatal clinics in Akure, Ondo State of Nigeria between November 2014 and December 2015. Methods:The HIV-1/2 strip was used for preliminary determination of HIV serostatus and this was followed by a confirmatory Abbott enzyme-linked immunosorbent assay (ELISA) procedure. CD4+ T-cell counts were done by cytometric analysis while viral load was determined by COBAS ® AmpliPrep TaqMan HIV-1 procedure. Liver enzymes were determined by an automated chemistry analyzer. Detection of hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus-6 (HPV-6) and herpes simplex virus type-2 (HSV-2) were determined by ELISA. The syphilis VDRL test was done by the rapid plasma reagin procedure, while Trichomonas vaginalis infection was demonstrated by the wet mount procedure. Infections with Chlamydia trachomatis and Neisseria gonorrhoeae were determined respectively by ELISA and by culture on proteose peptone agar supplemented with 5% serum. Results:The results show prevalence of STIs in 33.3% of the 240 study participants; 77.5% for HIV seropositive and 22.5% for seronegative subjects. Trichomonas vaginalis constituted the highest isolate

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Section: Discussionmentioning

confidence: 99%

Coinfections of Human Immunodeficiency Virus and Sexually Transmitted Infections among HIV Seropositive Pregnant Women at Healthcare Centres in Akure, Southwestern Nigeria

Kassim

2016

Int Arch Med

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“…The model extends the model for the transmission dynamics of TV and HIV in Bhunu and Mushayabasa, and is to the author's knowledge is the first to incorporate control strategies of TV and HIV coinfection in a population. In addition, it extends numerous TV models in the literature such as those in Bhunu and Mushayabasa and Bowden and Garnett by (inter alia): Allowing for TV transmission by treated individuals ( η ≠ 0), this is not considered in Bhunu and Mushayabasa, Subdividing the infected population with TV into counselled and noncounselled individuals, this is not considered in Bhunu and Mushayabasa, Assessing various control strategies for TV (counselling, treatment, and condom use). …”

Section: Model Formulationmentioning

confidence: 99%

“…Although it is one of the most prevalent nonviral STI's, it receives the least public health attention . Few papers have attempted a mathematical model on this topic . Trichomonas vaginalis requires more attention due to the damage it causes to the vaginal epithelium, which increases a woman's susceptibility to HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Mathematical analysis of a model for the transmission dynamics of Trichomonas vaginalis (TV) and HIV coinfection

Garba

Mumba

2018

Math Methods in App Sciences

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A deterministic model for the transmission dynamics of HIV and Trichomonas vaginalis (TV) in a human population is designed and rigorously analysed. The model is shown to exhibit the phenomenon of backward bifurcation, where a stable disease-free equilibrium coexists with a stable endemic equilibrium whenever the associated reproduction number is less than unity. This phenomenon can be removed by assuming that the coinfection of individuals with HIV and TV is negligible. Furthermore, in the absence of coinfection, the disease-free equilibrium of the model is shown to be globally asymptotically stable whenever the associated reproduction number is less than unity. Numerical simulation of the model, using initial and demographic data, shows that increased incidence of TV in a population increases HIV incidence in the population. It is further shown that control strategies, such as the treatment, condom use, and counselling of individuals with TV symptoms, can lead to the effective control or elimination of the HIV in the population if their effectiveness level is high enough. The time to disease elimination is reduced if more than one strategy (hybrid strategy) is considered.

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“…When combined, these versions may help researchers to understand the dynamics of HIV and tuberculosis co-infection. Treatment of Trichomoniasis vaginalis infections may aid in the battle against HIV/AIDS epidemic to a lesser extent, according to Bhunu et al [28], considering the high cost of antiretroviral drugs in underdeveloped nations, as well as the importance of Trichomoniasis, vaginalis infections in HIV transmission. Gandhi et al [29] have discussed dynamical features of a VL framework with time delay and specified stability conditions, as well as the occurrence of Hopf bifurcation.…”

Section: Introductionmentioning

confidence: 99%

A Mathematical modelling for co-infection dynamics of Japanese encephalitis-Dengue and influence of JE Vaccine on Dengue disease

Dwivedi,

Keval,

Baniya

2024

Proyecciones (Antofagasta)

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A non-linear deterministic mathematical model has been described with the co-infection dynamics of Japanese encephalitis(JE) and dengue disease, incorporating the JE vaccine. A basic reproduction number is discussed to study transmission potential of the co-infection model. In co-infection model, disease-free equilibrium points of Japanese encephalitis and dengue, along with endemic, are presented in system and investigated their stability with the help of their specified method. Our analysis suggests that vaccination against Japanese encephalitis positively affect control of co-infection. By using Center Manifold Theory, the model undergoes backwards bifurcation phenomenon and this has been occurred when basic reproduction number is smaller than unity. It is shown that by taking simultaneous preventive steps, the basic reproduction number of co-infection can be reduced to less than one after eliminating both infections. Sensitivity analysis has been performed to determine which parameters significantly affect disease dynamics. The effects of these parameters on transmission of disease were investigated using a numerical simulation. According to the findings, we obtain that JE-dengue co-infection can be managed with use of JE vaccine, also minimize JE transmission rate rapidly.

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Transmission dynamics of Trichomonas vaginalis and HIV/AIDS coinfection

Cited by 4 publications

References 28 publications

Coinfections of Human Immunodeficiency Virus and Sexually Transmitted Infections among HIV Seropositive Pregnant Women at Healthcare Centres in Akure, Southwestern Nigeria

Coinfections of Human Immunodeficiency Virus and Sexually Transmitted Infections among HIV Seropositive Pregnant Women at Healthcare Centres in Akure, Southwestern Nigeria

Mathematical analysis of a model for the transmission dynamics of Trichomonas vaginalis (TV) and HIV coinfection

A Mathematical modelling for co-infection dynamics of Japanese encephalitis-Dengue and influence of JE Vaccine on Dengue disease

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