Transmission from preganglionic fibres in the hypogastric nerve to peripheral ganglia of male guinea‐pigs

Blackman, J. G.; Crowcroft, P. J.; Devine, C.E.; Holman, Mollie E.; Yonemura, K

doi:10.1113/jphysiol.1969.sp008784

Cited by 83 publications

(18 citation statements)

References 17 publications

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“…In the vas deferens from the treated rats the noradrenaline concentration had fallen by only 50%. The noradrenergic innervation of this organ is supplied by pelvic ganglia which lie peripherally, are highly resistant to immunosympathectomy, and have certain properties reminiscent more of parasympathetic than of typical orthosympathetic ganglia (Blackman, Crowcroft, Devine, Holman & Yonemura, 1969).…”

Section: Discussionmentioning

confidence: 99%

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Clark¹,

Laverty²,

Phelan

1972

British J Pharmacology

151

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Summary1. In newborn rats treated with 6-hydroxydopamine hydrobromide (6-OHDA) (50-150 mg/kg on 5-7 days) a widespread and long-lasting dose related sympathectomy was demonstrated. 2. When rats given 6-hydroxydopamine (100 mg/kg, seven treatments) in the neonatal period were killed at 10 weeks the concentration of noradrenaline (NA) in the heart, mesentery and vas deferens was significantly reduced. There was no alteration in the catecholamine content of the adrenal glands. 3. The amplitude of the responses of perfused mesenteric arteries from 6-hydroxydopamine treated rats to intra-arterial noradrenaline was not increased, compared with controls, but the duration of responses was increased. 4. 6-Hydroxydopamine given to newborn rats caused a long-lasting depletion of noradrenaline in three of the five regions of the central nervous system (cortex, cerebellum and spinal cord) studied. The concentration of noradrenaline in the pons-medulla was increased, but in the thalamic region was unchanged. The treated rats showed significantly lower exploratory activity. 5. Treatment of newborn rats with 6-hydroxydopamine thus has striking and long-lasting effects on peripheral and central adrenergic systems.

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Section: Discussionmentioning

confidence: 99%

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Clark¹,

Laverty²,

Phelan

1972

British J Pharmacology

151

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“…It has been previously shown that these are very simple (mostly monopolar) neurons, which receive synaptic inputs from either the hypogastric or pelvic nerves (Tabatabai et al 1986). We found in the rat that very few neurons receive input from both nerves, in contrast to pelvic ganglia in guinea pigs and cats, where many neurons receive input from both spinal levels (Blackman et al 1969;Crowcroft and Szurszewski 1971;de Groat et al 1979). It had been previously reported that all neurons in male rat pelvic ganglia are activated by at least one large synaptic input and that most cells had additional subthreshold inputs (Tabatabai et al 1986).…”

Section: Properties Of Action Potential Afterhyperpolarizations (Ahps)mentioning

confidence: 95%

Postnatal Maturational Changes in Rat Pelvic Autonomic Ganglion Cells: A Mixture of Steroid-Dependent and -Independent Effects

Kanjhan

Osborne

Ouyang

et al. 2003

Journal of Neurophysiology

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Kanjhan, R., P. B. Osborne, M. Ouyang, and J. R. Keast. Postnatal maturational changes in rat pelvic autonomic ganglion cells: a mixture of steroid-dependent and -independent effects. J Neurophysiol 89: 315-323, 2003. 10.1152/jn.00479.2002. Androgens have potent effects on the maturation and maintenance of a number of neural pathways involved in reproductive behaviors in males. Most studies in this area have focused on central pathways, but androgen receptors are expressed by many peripheral neurons innervating reproductive organs, and previous studies have demonstrated structural and chemical changes in these neurons at puberty and after castration. We have performed the first electrophysiological comparison of pelvic autonomic ganglion neurons in male rats before and after puberty and following pre-or postpubertal castration. Studies were performed in vitro on intact ganglia with hypogastric and pelvic nerves attached to allow synaptic activation of sympathetic or parasympathetic neurons, respectively. Pelvic ganglion neurons underwent many changes in their passive and active membrane properties over the pubertal period, and some of these changes were dependent on exposure to circulating androgens. The most pronounced steroid-dependent effects were on membrane capacitance (soma size) in sympathetic neurons and duration of the action potential afterhyperpolarization in tonic neurons. Our study also showed that rat pelvic ganglion cells and their synaptic inputs were more diverse than previously reported. In conclusion, this study demonstrated that rat pelvic ganglion neurons undergo considerable postnatal changes in their electrophysiological properties. The steroid dependence of some of these changes indicates that circulating androgens may influence reproductive behaviors at many locations within the nervous system not just in the brain and spinal cord.

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“…Since the pioneer work of Langley & Anderson (1896 a, b), it has been repeatedly confirmed that some preganglionic fibres in the pelvic nerve form synapses with nerve cells in the pelvic plexus (Blackman, Crowcroft, Devine, Holman & Yonemura, 1969;de Groat & Krier, 1978). On the other hand, Gillespie (1968) showed that cholinergic preganglionic nerves in the colonic wall synapse with cholinergic cells in the myenteric plexus.…”

Section: Introductionmentioning

confidence: 98%

Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.

Fukai

Fukuda²

1985

The Journal of Physiology

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SUMMARY1. Electrophysiological and histological techniques were used to study the nature of the innervation of the colon by the sacral parasympathetic nerve of the dog.2. Many cells which incorporate horseradish peroxidase (HRP) were observed in ganglia of the pelvic plexus, but not in the sacral cord, after HRP was injected into the wall of the distal colon. Stimulation of the pelvic ganglia by an application of dimethylphenylpiperazinium contracted the distal colon. The contraction was reduced by nicotine applied to the colon.3. Compound action potentials in responses of rectal strands of the pelvic nerve to stimulation of the sacral ventral roots decreased or disappeared after hexamethonium bromide (C6) was applied to the pelvic plexus. Conduction velocities of the potentials showed that most of the preganglionic fibres were B fibres, and nearly all the post-ganglionic fibres were C fibres.4. Many C fibres were observed by electron microscopy in the rectal strands after degeneration of the pelvic and hypogastric nerves. Stimulation of such rectal strands caused a contraction of the colon, which diminished after C6 was applied to the distal colon.5. These results show that the sacral parasympathetic nerve innervating the colon comprises three serial neurones located in the sacral spinal cord, the pelvic plexus and the myenteric plexus.

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Transmission from preganglionic fibres in the hypogastric nerve to peripheral ganglia of male guinea‐pigs

Cited by 83 publications

References 17 publications

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Long‐lasting peripheral and central effects of 6‐hydroxydopamine in rats

Postnatal Maturational Changes in Rat Pelvic Autonomic Ganglion Cells: A Mixture of Steroid-Dependent and -Independent Effects

Three serial neurones in the innervation of the colon by the sacral parasympathetic nerve of the dog.

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