Transmission FTIR derivative spectroscopy for estimation of furosemide in raw material and tablet dosage form

Abstract

A Fourier transform infrared derivative spectroscopy (FTIR-DS) method has been developed for determining furosemide (FUR) in pharmaceutical solid dosage form. The method involves the extraction of FUR from tablets with N,N-dimethylformamide by sonication and direct measurement in liquid phase mode using a reduced path length cell. In general, the spectra were measured in transmission mode and the equipment was configured to collect a spectrum at 4 cm−1 resolution and a 13 s collection time (10 scans co-added). The spectra were collected between 1400 cm−1 and 450 cm−1. Derivative spectroscopy was used for data processing and quantitative measurement using the peak area of the second order spectrum of the major spectral band found at 1165 cm−1 (SO2 stretching of FUR) with baseline correction. The method fulfilled most validation requirements in the 2 mg/mL and 20 mg/mL range, with a 0.9998 coefficient of determination obtained by simple calibration model, and a general coefficient of variation <2%. The mean recovery for the proposed assay method resulted within the (100±3)% over the 80%–120% range of the target concentration. The results agree with a pharmacopoeial method and, therefore, could be considered interchangeable.

Influence of variation in molar ratio on co-amorphous drug-amino acid systems

“…We have previously suggested that Fur forms a dimer in the amorphous form via hydrogen bonds between the carboxylate and the sulfonamide groups (16). This is finding is supported by the FTIR spectra, as the strong SO 2 asymmetric stretching band at 1140 cm -1 in crystalline Fur is highly reduced in the FTIR spectrum of amorphous Fur (30).…”

Ultraviolet irradiation of glycine in presence of pyrite as a model of chemical evolution: an experimental and molecular modelling approach

“…For some authors (Barth & Haris 2009), this advantage consists of a second derivative that is straightforward and requires no a priori knowledge of band parameters. An additional application of these procedures is that the solute concentration in the Beer–Lambert law (1) lc or in its second derivative (2) is not affected (Gallignani et al 2014). …”

Co-Amorphous Formulations of Furosemide with Arginine and P-Glycoprotein Inhibitor Drugs

“…In the co-amorphous FUR:VER 1:1 and 1:2 mixtures ( Figure 2 a), these peaks had shifted to higher wavenumbers, i.e., to 1677 and 1681 cm −1 , and 1565 and 1567 cm −1 , respectively. The peaks at 1315 cm −1 (asymmetric SO 2 stretching) and 1139 cm −1 (symmetric SO 2 stretching) in FUR [ 35 ] had shifted to 1325 and 1331 cm −1 , and to 1143 and 1145 cm −1 in the co-amorphous FUR:VER 1:1 and 1:2, respectively.…”