Transmission of afferent information from urinary bladder, urethra and perineum to periaqueductal gray of cat

Duong, Myto; Downie, John W.; Du, Huan-Ji

doi:10.1016/s0006-8993(98)01294-3

“…In the rat, electrical stimulation of bladder afferents in the pelvic nerve elicits negative field potentials in the dorsal PAG at a mean latency of 13 ms which is considerably shorter than the mean latency of field potentials in the region of the PMC (42 ms) (479). In the cat, a similar difference between latencies of pelvic afferent evoked field potentials in the PAG (11 ms) (202) and PMC in the (30–40 ms) (142) has been noted.…”

Section: Voiding Mechanismssupporting

confidence: 53%

“…Some of these interneurons make excitatory and inhibitory synaptic connections with PGN (27, 28, 150, 429) and participate in segmental spinal reflexes (150); whereas others send long projections to supraspinal centers, such as the PAG (Figs. 8 and 12), PMC (Barrington’s nucleus), the hypothalamus and thalamus that are involved in the supraspinal control of micturition (60, 68, 71, 184, 202, 270, 425). …”

Section: Anatomy Of the Spinal Pathways Controlling The Lower Urinarymentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

Groat

¹

,

Griffiths

²

,

Yoshimura

³

2014

Comprehensive Physiology

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

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“…Several studies have revealed that neurons ascending from the sacral spinal cord have more neural communications with the PAG than with the PMC (6,8,21). Recent studies with positron emission tomography in humans showed an increase in regional cerebral blood flow in the PAG during urine storage (2,16).…”

mentioning

confidence: 99%

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Numata¹,

Iwata²,

Iuchi³

et al. 2008

American Journal of Physiology-Regulatory, Integrative and Comp

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The periaqueductal gray (PAG) of the mesencephalon has been implicated to be involved in the control of micturition. We investigated the micturition-suppressing region in the PAG of the cat. Decerebrated 27 adult cats were used. A microelectrode was inserted stereotaxically into the PAG, and a region was searched where electrical stimulation suppressed isovolumetric bladder contractions. Simultaneous stimulation of the pontine micturition center (PMC) and micturition-suppressing region in the PAG was performed before and after an injection of bicuculline (GABA(A) blocker) into the PMC. The micturition-suppressing region was found at the dorsolateral margin of the rostral PAG. Bladder contractions were not provoked by simultaneous stimulation of the PMC and micturition-suppressing region in the PAG. However, after bicuculline injection into the PMC, partial bladder contractions were provoked by simultaneous stimulation of the PMC and the micturition-suppressing region in the PAG. These results suggest that the dorsolateral margin of the rostral PAG includes the micturition-suppressing region that seems to have neural connections with the PMC. GABA is assumed to be one of the neurotransmitters that are involved in the PMC inhibition from the micturition-suppressing region in the PAG.

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“…In the rat, electrical stimulation of bladder afferents in the pelvic nerve elicits negative field potentials in the dorsal PAG at a mean latency of 13 ms which is considerably shorter than the mean latency of field potentials in the region of the PMC (42 ms) (479). In the cat, a similar difference between latencies of pelvic afferent evoked field potentials in the PAG (11 ms) (202) and PMC in the (30-40 ms) (142) has been noted.…”

Section: Brain Stem Circuitry: Spinobulbospinal Micturition Reflexmentioning

confidence: 95%

Neural Control of the Lower Urinary Tract

2009

Encyclopedia of Neuroscience

0

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

show abstract

Transmission of afferent information from urinary bladder, urethra and perineum to periaqueductal gray of cat

Cited by 25 publications

References 40 publications

Neural Control of the Lower Urinary Tract

Neural Control of the Lower Urinary Tract

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat

Neural Control of the Lower Urinary Tract

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