Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation

Increasing dietary nitrate has no effect on cancellous bone loss or fecal microbiome in ovariectomized rats

“…Further, OVX GF mice are protected from both cancellous and cortical bone loss 30. Since altered microbiome composition is associated with chronic disease and that specific microbiota interacts with the immune system 66, 67, 68, 69, 70, it has been hypothesized that gut microbiome composition may influence the magnitude of bone loss in postmenopausal women 30. Sex steroid deficiency results in a chronic inflammatory state that may contribute to osteoporosis 71.…”

Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD

“…4,5 Pathophysiologically, TMAO may also interact with other host neurohormonal systems, as observed in a rat model whereby angiotensin II infusion in the setting of elevated TMAO levels led to sustained augmentation of BP. 10 Specific microbial genre potentially responsible for enhanced TMA/ TMAO generation have been identified, 4,11 and microbial transplantation studies have confirmed the obligatory role of dietary-induced TMAO-producing intestinal microflora in atherogenesis. 11 In a subsequent study of .4000 patients undergoing elective coronary angiography, elevated TMAO levels predicted death, myocardial infarction, and stroke over a 3-year period of stable patients who electively underwent coronary angiography.…”

“…10 Specific microbial genre potentially responsible for enhanced TMA/ TMAO generation have been identified, 4,11 and microbial transplantation studies have confirmed the obligatory role of dietary-induced TMAO-producing intestinal microflora in atherogenesis. 11 In a subsequent study of .4000 patients undergoing elective coronary angiography, elevated TMAO levels predicted death, myocardial infarction, and stroke over a 3-year period of stable patients who electively underwent coronary angiography. 6 Although elevated circulating L-carnitine and choline/betaine levels (all substrates of TMAO production) were also associated with future risk, their prognostic values were primarily restricted to those with concomitant elevated TMAO levels.…”

Nutrigenomics: A Systems Approach to Cardiometabolic Disease and Personal Nutrition

“…This was the first demonstration that atherosclerosis susceptibility can be transmitted via transplantation of gut microbiota. The study recognizes that gut microbes represent a novel therapeutic target for modulating atherosclerosis susceptibility [14]. Recently, at the 11th International Functional Foods Workshop data was presented that supports continued investments into the development of functional foods that impact cardiovascular health [15].…”

“…Recent human and animal studies indicate clinical and mechanistic links between heart disease and intestinal microbial metabolism of certain dietary nutrients (carnitine, choline and phosphatidylcholine) producing trimethyl-amine N-oxide (TMAO). TMAO is a microbiotadependent metabolite that participates in atherosclerotic plaque formation [14].…”