Transmission of betapapillomaviruses between domestic partners in an Australian community

Plasmeijer, Elsemieke I.; Green, Adèle C.; Koning, Maurits N.C. de; O’Rourke, Peter; Quint, Wim; Feltkamp, Mariet C.W.; Neale, Rachel E.

doi:10.1016/j.jcv.2009.12.004

Cited by 6 publications

(9 citation statements)

References 20 publications

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“…The number of simultaneously detected antibodies was associated with the number of betaPV types present in eyebrow hairs (P < 0.001). Antibodies against HPV5, 8,15,20,24,38,49, and 92 were statistically significantly associated with the presence of the same type in eyebrow hairs (P < 0.05), whereas this association was not apparent for HPV 9, 17, 23, 36, 75, 76, and 93.…”

Section: Betapv Infection and Seropositivity Are High In The 3 Countriesmentioning

confidence: 89%

“…The presence of antibodies to the major capsid protein L1 of 15 betaPV types (i.e., HPV5, 8,9,15,17,20,23,24,36,38,49,75,76,92, and 93) was analyzed in a multiplex analyzer (Luminex) as previously described (22,40). Concerning quality control measures, the glutathione-casein-coupled bead sets were loaded with their respective antigens in 1 batch.…”

Section: Betapv Serologymentioning

confidence: 99%

“…The presence of betaPV evokes a serologic response (22) in a proportion of people infected (23). Little is known about the relation between betaPV infection and seroreactivity (24), but it is conceivable that detectable betaPV antibodies are indicators of an infection that is present at a higher viral load, perhaps due to local proliferation and inflammation of the skin (25). Several studies have shown associations between serologic responses to betaPV and squamous cell carcinoma or actinic keratoses (26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%

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Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

et al. 2010

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Human papillomaviruses (betaPV) from the beta genus cannot be classified according to their oncogenicity due to a paucity of information. This study evaluates the association between betaPV infection and cutaneous squamous cell carcinoma in conjunction with measures of UV exposure and susceptibility. We performed casecontrol studies in the Netherlands, Italy, and Australia, countries with profoundly different UV exposures. The presence of 25 betaPV types in eyebrow hair follicles was determined using a highly sensitive HPV DNA genotyping assay, and antibodies for the 15 most prevalent betaPV types in a total of 689 squamous cell carcinoma cases and 845 controls were detected using multiplex serology. Multivariate logistic regression models were used for case-control comparisons and interaction analyses. BetaPV DNA was detected in eyebrow hairs of more than 90% of all participants. The presence of betaPV DNA was associated with an increased risk of squamous cell carcinoma in the Netherlands (OR ¼ 2.8; 95% CI 1.3-5.8) and Italy (OR ¼ 1.7; 95% CI 0.79-3.6), but not in Australia (OR ¼ 0.91; 95% CI 0.53-1.6). Seropositivity for betaPV in controls ranged between 52% and 67%. A positive antibody response against 4 or more betaPV types was associated with squamous cell carcinoma in Australia (OR ¼ 2.2; 95% CI 1.4-3.3), the Netherlands (OR ¼ 2.0; 95% CI 1.2-3.4) and fair-skinned Italians (OR ¼ 1.6, 95% CI 0.94-2.7). The association between UV susceptibility and squamous cell carcinoma was stronger in betaPV-seropositive people. These combined data support the hypothesis that betaPV may play a role in the development of cutaneous squamous cell carcinoma. Cancer Res; 70(23); 9777-86. Ó2010 AACR.

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Section: Betapv Infection and Seropositivity Are High In The 3 Countriesmentioning

confidence: 89%

Section: Betapv Serologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

et al. 2010

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“…Male self-inoculation also was observed to occur and was attributed to casual contact or masturbation. The feasibility of HPV transmission through sex related skin-to-skin contact also was demonstrated in a cross-sectional study which found that co-habiting partners of the opposite-sex shared a greater number of beta-PV types than either shared with randomly selected matched members of the population 248. Among participants in this study with at least one virus infection (26 couples), 74% of the partners and 46% of the control pairs shared at least one type ( P = 0.02).…”

Section: Human Papillomavirus Virusmentioning

confidence: 95%

The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

Efird

Toland

Lea

et al. 2011

Clin Med Insights Oncol

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The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important population at great risk for CSCC. An association has been reported between oral contraceptive (OC) use, human papillomavirus virus (HPV) and cervical cancer, and there could be a similar association for CSCC. The cutaneous HPV β-E6 protein, a close cousin of the transformative E6 protein underlying anogenital cancers, has been shown to inhibit apoptosis in response to UVR damage and stimulate morphologic transformation in rodent fibroblast cell lines. Furthermore, OC use has been shown to enhance HPV transcription and may contribute to CSCC risk through this pathway.

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“…In the last decade, several studies have shown that HPV DNA can be recovered from healthy skin in humans from very early stages of life [6], [21], that skin infections with multiple HPV genotypes are very common [7], [22], [23] and that several recently identified cutaneous HPVs may not be associated with any clinical manifestations [5], [24]. In view of these facts, the clinical significance of any novel HPV genotype needs to be carefully examined.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Novel Cutaneous Human Papillomavirus Genotypes HPV-150 and HPV-151

et al. 2011

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DNA from two novel HPV genotypes, HPV-150 and HPV-151, isolated from hair follicles of immuno-competent individuals, was fully cloned, sequenced and characterized. The complete genomes of HPV-150 and HPV-151 are 7,436-bp and 7,386-bp in length, respectively. Both contain genes for at least six proteins, namely E6, E7, E1, E2, L2, L1, as well as a non-coding upstream regulatory region located between the L1 and E6 genes: spanning 416-bp in HPV-150 (genomic positions 7,371 to 350) and 322-bp in HPV-151 (genomic positions 7,213 to 148). HPV-150 and HPV-151 are phylogenetically placed within the Betapapillomavirus genus and are most closely related to HPV-96 and HPV-22, respectively. As in other members of this genus, the intergenic E2-L2 region is very short and does not encode for an E5 gene. Both genotypes contain typical zinc binding domains in their E6 and E7 proteins, but HPV-151 lacks the regular pRb-binding core sequence within its E7 protein. In order to assess the tissue predilection and clinical significance of the novel genotypes, quantitative type-specific real-time PCR assays were developed. The 95% detection limits of the HPV-150 and HPV-151 assays were 7.3 copies/reaction (range 5.6 to 11.4) and 3.4 copies/reaction (range 2.5 to 6.0), respectively. Testing of a representative collection of HPV-associated mucosal and cutaneous benign and malignant neoplasms and hair follicles (total of 540 samples) revealed that HPV-150 and HPV-151 are relatively rare genotypes with a cutaneous tropism. Both genotypes were found in sporadic cases of common warts and SCC and BCC of the skin as single or multiple infections usually with low viral loads. HPV-150 can establish persistent infection of hair follicles in immuno-competent individuals. A partial L1 sequence of a putative novel HPV genotype, related to HPV-150, was identified in a squamous cell carcinoma of the skin obtained from a 64-year old immuno-compromised male patient.

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Transmission of betapapillomaviruses between domestic partners in an Australian community

Cited by 6 publications

References 20 publications

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

Multicenter Study of the Association between Betapapillomavirus Infection and Cutaneous Squamous Cell Carcinoma

The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma

Characterization of Novel Cutaneous Human Papillomavirus Genotypes HPV-150 and HPV-151

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