Transmission of Bovine Leukosis by Serum, Blood, Bone-marrow and Leukocytes

Weinhold, Elmar G.; Straub, O C

doi:10.1159/000391242

Cited by 4 publications

(2 citation statements)

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“…It should be pointed out that Cow 10 developed PL from the 3rd month after oral administration, a fact which, as emphasized previously (HATZIOLOS, 1968 a), concurs with the concept of a vertical or horizontal transmission of the bovine leukemia agent particularly via colostrum and milk. This natural transmission, as suggested earlier (MARSHAK and DUTCHER, 1965), was observed in experimental studies (THEILEN et al, 1967;WEINHOLD and STRAUB, 1968), and was recently confirmed (LARSON et al, 1970). Milk could serve as a mechanical vector with whole neoplastic cells as does the mosquito in transmitting oncogenesis in hamsters (BANFIELD et al, 1965).…”

Section: Histopathologic Changessupporting

confidence: 67%

Bovine Lymphosarcoma: The Effect of Inoculations on Newborn Calves

Hatziolos

2010

Zentralblatt Für Veterinärmedizin Reihe B

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Summary Eight cattle originally inoculated at birth with bovine lymphosarcoma (BLS) material were observed during the 5th and 6th years of life. The inoculum had been given in the form of emulsion i. p. (group I), sonicated extracts parenterally (group II) or per os daily for 16 days (group III) and tissue culture i. v. or i. p. (group IV). Twenty‐eight normal cows of the same age taken from a leukemia‐free dairy herd, and 2 others of the same age with special conditions were included as controls (group V). One of these, 179, from a herd with a history of a single instance of lymphosarcoma, had lymphocytosis. RBC, PCV, and hemoglobin values of all the animals were within the physiological limits. Variations appeared to be related to the management of the animals. The majority of group I and II animals had CLC counts at suspicious levels. The CLC counts of one cow in group III remained at high positive levels, as they had since shortly after the animal received the agent per os; the second cow of this group developed CLC counts, from a previous suspicious state, to positive levels, during the 6th year. In group IV, both animals had CLC counts at positive levels for both years of observation. The average CLC counts of the control cows, with the exception of Cow 179, which had PL for more than 5 years, remained at suspicious levels. However, a good number of cows with increased CLC counts had records of chronic conditions. At necropsy, the inoculated cattle had no real neoplastic changes. Noted were areas of cortical hyperplasia in some lymph nodes and partial fibrosis or a combination of both in others. Wide cortex with compact areas, effaced trabeculae, and sinuses tightly packed with immature lymphoid cells or blastcells were noted in the lymph nodes and spleen of animals of group III and IV. Hematologic and histologic changes were attributed to the inoculum and for some animals could indicate a prodromal leukemic state. Changes in some of the lymph nodes of Cow 179 are believed to be related to the persistent lymphocytosis. Résumé Lymphosarcome bovin: effet d'une inoculation chez les veaux nouveau‐nés III. Observations au cours des cinquième et sixième années On observe au cours de leurs 5ème et 6ème années, 8 bovins, auxquels on avait inoculé des prélèvements de lymphosarcome bovin au moment de leur naissance. L'inoculum avait été administré sous forme d'une émulsion i. p. (groupe 1), d'extraits traités aux ultra‐sons, par voie parentérale (groupe 2) ou per os, chaque jour pendant 16 jours (groupe 3) et d'une culture de tissus i. v. ou i. p. (groupe 4). Comme contrôle (groupe 5), on utilise 28 vaches laitières normales du même âge, provenant d'un troupeau exempt de leucémie et deux autres du même âge se trouvant dans des conditions spéciales. L'une des deux (No. 179), provenant d'un troupeau avec un cas de lymphosarcome, était atteinte d'une lymphocytose. Chez tous les animaux, le nombre des érythrocytes, le volume cellulaire total et les taux d'hémoglobine varient dans les limites physiologiques. Les variation...

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Section: Histopathologic Changessupporting

confidence: 67%

Bovine Lymphosarcoma: The Effect of Inoculations on Newborn Calves

Hatziolos

2010

Zentralblatt Für Veterinärmedizin Reihe B

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“…There was agreement that this complex disease is probably an infectious process of viral etiology; that susceptibility is a genetic characteristic and among susceptible animals transmission may occur either vertically or horizontally (20). WEI~OLD and STRAUB (31) among cattle by inoculation of tissues, and they referred to the previous studies of similar nature. There are many reports of viruses associated with lymphomatous tissues or leukocyges of the bovine (8--15, 18, 19, 21--24, 27, 30).…”

Section: Introductionmentioning

confidence: 99%

A small intranuclear virus recovered from lymphatic tissue of a bovine with malignant lymphoma

Burroughs

Cardinet

1973

Archiv f Virusforschung

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Madin-Darby Bovine Kidney (MDBK) ceils were permanently infected with a virus following inoculation and long-term incubation with lymphatic tissue from a 7-year-old bovine with lymphocytic type of malignant lymphoma. The virus, passed to a calf by dripping a suspension into its eyes, nostrils, and mouth, was recovered from lymphatic tissue 106 days later. One of 6 calves inoculated with a quantity of concentrated virus suspension developed persistent lymphoeytosis in approximately 2 years. Permanently infected MDBK cells of a line infected for several months were agglutinated by both coneanavalin A and wheat germ lipase contaminant. Electron mierographs of thin sections of cells revealed many virions in the nuclei. Enveloped particles ranged from 47 to 58 m~x in diameter. Autoradiographic studies resulted in labelling the intranuclear virions of infected cells with uridine-5-3H. Incorporation of isotope was not inhibited by FUdR and actinomycin D.

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Studies on increasing the virulence of the bovine leukosis virus

Straub

1976

Theriogenology

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Transmission of Bovine Leukosis by Serum, Blood, Bone-marrow and Leukocytes

Cited by 4 publications

References 0 publications

Bovine Lymphosarcoma: The Effect of Inoculations on Newborn Calves

Bovine Lymphosarcoma: The Effect of Inoculations on Newborn Calves

A small intranuclear virus recovered from lymphatic tissue of a bovine with malignant lymphoma

Studies on increasing the virulence of the bovine leukosis virus

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