This study was conducted to estimate the prevalence and identify risk factors associated with trematode infections in cattle in and around Bahir Dar, northwest Ethiopia. Fecal samples collected from randomly selected 369 cattle were examined using simple sedimentation technique for differential trematode eggs count. The animals were found shedding eggs of three groups of trematodes, namely
Fasciola
spp., paramphistomes and
Schistosoma
spp. The overall prevalence of trematodes was 61.0%, and specific prevalence for
Fasciola
, paramphistomes and
Schistosoma
was 20.1%, 48.5% and 16.5%, respectively. A substantial overlap was observed in the occurrence of
Fasciola
and paramphistomes. The prevalence of all the three trematodes identified in this study was significantly (
P
< 0.05) associated with body condition and breed, while the prevalence of
Fasciola
and paramphistomes was also associated with age. The mean (± SE) fecal egg count per gram of feces (EPG) for
Fasciola
, paramphistomes and
Schistosoma
was 4.3 (± 0.55), 25.7 (± 2.11) and 3.1 (± 0.42), respectively. EPG of
Fasciola
was significantly correlated with EPG of paramphistomes (
P
<
0.001). The EPG for all the three trematodes was associated with body condition and breed of animals (
P
< 0.05), while EPG for paramphistomes was also affected by age of the animals (
P
< 0.05). The prevalence of all the three major trematodes of animal health importance with high rate of mixed infection along with poor body condition, suggests substantial economic loss incurred due to reduced productivity in cattle in the study area.