Transmission of Creutzfeldt-Jakob disease by blood transfusion

Klein, Renate; Dumble, Lynette J.

doi:10.1016/0140-6736(93)90549-v

Cited by 79 publications

(28 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 15-, or, even the 35-nm membranes used here, as well as other possible filtration systems [25], may allow steric removal of any presently known viruses, regardless of their structure or resistance to physicochemical treatments. A recent paper also indicates that, under certain experimen tal conditions, a 35-nm membrane used to filter a mouse brain extract could remove aggregated Creutzfeldt-Jakob agent [26], opening even broader perspectives in the safety of biological products, possibly including blood-derived products [27], Finally, it remains to be seen whe ther higher molecular weight plasma proteins, such as factor VIII, or even von Willebrand factor concentrates, can be nanofiltered on 15-or 35-nm membranes under conditions allowing good recovery of biological activity. High-purity preparations with low protein content may be good candi dates for the nanofiltration process.…”

Section: Discussionmentioning

confidence: 99%

Nanofiltration, a New Specific Virus Elimination Method Applied to High-Purity Factor IX and Factor XI Concentrates

Burnouf-Radosevich¹,

Appourchaux²,

Huart³

et al. 1994

Vox Sanguinis

View full text Add to dashboard Cite

We have validated the use of two new regenerated multilayered structured cellulose membranes (BMM), Planova 15 N and Planova 35 N, with respective mean pore sizes of 15 and 35 nm, as a new filtration system to eliminate viruses in highly purified factor IX and factor XI concentrates. Virus spiking experiments indicated that single dead-end filtration on the membranes could remove more than 5.7-7.8 log10 of human immunodeficiency virus, bovine viral diarrhoea virus, porcine pseudorabies virus, reovirus type 3, and simian virus 40, as well as the small non-enveloped viruses, poliovirus Sabin type 1 and bovine parvovirus. In vitro control tests and animal studies (Wessler stasis model, rat hypotension model) of the two concentrates did not reveal any significant differences with the non-nanofiltered material. Viral filtration of plasma derivatives on porous polymeric membranes might be an essential step in the improvement of their viral safety.

show abstract

Section: Discussionmentioning

confidence: 99%

Nanofiltration, a New Specific Virus Elimination Method Applied to High-Purity Factor IX and Factor XI Concentrates

Burnouf-Radosevich¹,

Appourchaux²,

Huart³

et al. 1994

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…The recipient of a kidney obtained from the same donor, which had to be replaced by another donor kidney 2 months after the first transplantation, was in good health at the time of publication. Other case reports frequently contain even less indications for the transmission of the agent by transfusion [27]. As is the matter with the case described above, the concern usually is to claim an iatrogenic cause for a disease which might also go for a sporadic case of CJD.…”

Section: Case Reportsmentioning

confidence: 99%

Creutzfeldt-Jakob Disease and Human Transmissible Spongiform Encephalopathies

2005

Transfus Med Hemother

View full text Add to dashboard Cite

“…[1,9,10] Son y llarda FBS kullan m na ba l alerji ve baz prion bula riski nedeniyle farkl kültür teknikleri denenmektedir. Serumsuz media kullan m , trombositten zengin plazma, AB pozitif serum bunlardan baz lar d r. [16][17][18][19][20][21][22][23][24][25] Bu çal mada sa l kl vericilerden elde edilen MKH'lerin, %10 otolog serum (OS), %5 OS, %3 OS ve %1 OS kullan larak kültüre edilmesi ve FBS ile kültüre edilen MKH'lerle say , görünüm, immunfenotipik özel-likler ve ya dokusuna farkl la ma yönünden kar la tr lmas amaçland .…”

Section: G Runclassified

Autologous Serum For Expansion Of Human Bone Marrow Derivated Mesenchymal Stem Cell

Kozanoğlu¹,

Boğa²,

Maytalman³

et al. 2009

TUTFD

View full text Add to dashboard Cite

© Trakya Üniversitesi T p Fakültesi Dergisi. AVES Yay nc l k taraf ndan bas lm t r. Her hakk sakl d r. © Medical Journal of TrakyaAmaç: Mezenkimal kök hücreler (MKH) en s k kemik ili inden elde edilen ve bir çok dokuya farkl la ma yetene ine sahip çok yönelimli öncü hücrelerdir. MKH'ler %10 fetal bovin serumlu (FBS) besiyerinde üretilirler. Bu çal mada amaç FBS'un olas risklerinden uzaklalmas için otolog serum kullanarak klinik kullan m için uygun MKH üretimini sa lamakt r. Gereç ve Yöntemler:Ya lar 28-34 aras nda de i en 10 kemik ili i donoründen yaz l onamlar al narak 10 mL kemik ili i ve 500 mL periferik kan örne i al nd . Kemik ili inden fikol yo unluk derecelendirme yöntemiy-le mononükleer hücreler izole edildi. E it say da hücre (1x10 6 /mL) RPMI-1640 medium kullan larak %10 FBS, otolog serum (OS), %10, %5, %3 ve %1 konsantrasyonlar nda kültüre edildi. Her pasaj aras nda morfolojik de erlendirme, hücre say m ve ak m sitometrik yöntem-ler kullan larak immunfenotipik analizler yap ld . Üçüncü pasaja ula an gruplarda ya dokusuna farkl la t rma gerçekle tirildi. Bulgular:Hücre say m ve izolasyon aç s ndan en iyi grubun %10 OS grubu oldu u gösterildi. Buna ilave olarak %5 OS ve %10 FBS gruplar ndaki sonuçlar n benzer oldu u gözlemlendi. Ak m sitometrik sonuçlar de erlendirildi inde gruplar aras nda istatistiksel fark yoktu. Ya dokusuna farkl la t rma aç s ndan %3 OS ve %1 OS d nda di er gruplarda farkl la ma sa land .Sonuç: Sonuç olarak özellikle %10 OS ve %5 OS kullan larak MKH kültürleri yap labilece i saptand .Anahtar sözcükler: Mezenkimal kök hücre; otolog serum; kemik ili i; fetal buza serum.Objective: Mesenchymal stem cells (MSC), mostly derivated from bone marrow, are capable of differentiating into many tissues. In the culture medium consisting of 10% fetal bovine serum (FBS), MSCs can grown easily. To obtain insights into their ex-vivo expansion, the role of the autologous serum (OS) on growth and differentiation capacity of human bone marrow MSCs in comparison to cells grown in FBS was studied. Material and Methods:MSCs were cultured by using a RPMI-1640 medium consisting of 10% FBS, and OS 10%, 5%, 3% and 1%. Equally, 1x10 6 /mL cells were incubated into each flask. Cell count, viability, and flow cytometry studies were done at every passage after completing detachment in the cultures.Results: 10% OS group was found to be superior compared to the other study groups as regard to cell count and isolation. In addition, it has been observed that similar resuts were found in 5% OS and 10% FBS groups. Immunophenotyping analysis of the cells revealed no statistical difference between the groups. MSCs isolated from all study groups were successfully differentiated into adipogenic lineages except 3% and 1% OS groups. Conclusion:The expansion potency from bone marrowderived MSCs was maintained in culture media using 10% and 5% OS.

show abstract

Transmission of Creutzfeldt-Jakob disease by blood transfusion

Cited by 79 publications

References 2 publications

Nanofiltration, a New Specific Virus Elimination Method Applied to High-Purity Factor IX and Factor XI Concentrates

Nanofiltration, a New Specific Virus Elimination Method Applied to High-Purity Factor IX and Factor XI Concentrates

Creutzfeldt-Jakob Disease and Human Transmissible Spongiform Encephalopathies

Autologous Serum For Expansion Of Human Bone Marrow Derivated Mesenchymal Stem Cell

Contact Info

Product

Resources

About