Transmission of Hepatitis C in a Pharmacologic Study

Saginur, Raphael; Nixon, Judith; Devries, Barbara; Bruce, Natalie; Carruthers, Christopher; Scully, L. J.; Berger, Rachel P.; Leech, Judy; Nicolle, Lindsay E.; Mackenzie, A. M. R.

doi:10.1086/501848

Cited by 9 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…URATION OF ANTIMICRObial therapy is critically important because insufficient treatment can lead to therapeutic failure or recurrent disease, 1,2 whereas prolonged treatment can increase costs, promote antimicrobial resistance, and increase the risk for Clostridium difficile infection (CDI). 3,4 The optimal treatment duration for urinary tract infection (UTI) in ambulatory, noncatheterized women is well defined.…”

mentioning

confidence: 99%

Urinary Tract Infection in Male Veterans

Drekonja¹,

Rector²,

Cutting³

et al. 2013

JAMA Intern Med

120

View full text Add to dashboard Cite

Background: Lengthier antimicrobial therapy is associated with increased costs, antimicrobial resistance, and adverse drug events. Therefore, establishing minimum effective antimicrobial treatment durations is an important public health goal. The optimal treatment duration and current treatment patterns for urinary tract infection (UTI) in men are unknown. We used Veterans Affairs administrative data to study male UTI treatment and outcomes.Methods: Male UTI episodes in the Veterans Affairs system (fiscal year 2009) were identified by combining International Classification of Diseases, Ninth Revision codes with UTI-relevant antimicrobial prescriptions. Episodes were categorized as index, early recurrence (Ͻ30 days), or late recurrence (Ն30 days) cases. Drug name, treatment duration, and outcomes (recurrence and Clostridium difficile infection during 12 months) were recorded for index cases. Demographic, clinical, and treatment characteristics were assessed for associations with outcomes in univariate and multivariate analyses.Results: Among 4 854 765 outpatient male veterans, 39 149 UTI episodes involving 33 336 unique patients were identified, including 33 336 index cases (85.2%), 1772 early recurrences (4.5%), and 4041 late recurrences (10.3%). Highest-use antimicrobial agents were ciprofloxacin (62.7%) and trimethoprim-sulfamethoxazole (26.8%); 35.0% of patients received shorterduration treatment (Յ7 days), and 65.0% of patients received longer-duration treatment (Ͼ7 days). Of the index cases, 4.1% were followed by early recurrence and 9.9% by late recurrence. Longer-duration treatment was not associated with a reduction in early or late recurrence but was associated with increased late recurrence compared with shorter-duration treatment (10.8% vs 8.4%, P Ͻ .001), including in multivariate analysis (odds ratio, 1.20; 95% CI, 1.10-1.30). In addition, C difficile infection risk was significantly higher with longerduration vs shorter-duration treatment (0.5% vs 0.3%, P =.02) and exhibited a similar suggestive trend in multivariate analysis (odds ratio, 1.42; 95% CI, 0.97-2.07). Conclusion:Longer-duration treatment (Ͼ7 days) for male UTI in the outpatient setting was associated with no reduction in early or late recurrence.

show abstract

mentioning

confidence: 99%

Urinary Tract Infection in Male Veterans

Drekonja¹,

Rector²,

Cutting³

et al. 2013

JAMA Intern Med

120

View full text Add to dashboard Cite

show abstract

“…These patients were hospitalized in surgical as well as medical departments and in seven different hospitals including small community hospitals, private clinics and university tertiary care centers. This, we believe, is an important finding as there is a growing body of evidence implicating patient‐to‐patient transmission as result of unsafe injection practices and equipment 1–3,8 , 23,24 , 27–31 …”

Section: Discussionmentioning

confidence: 64%

“…This, we believe, is an important finding as there is a growing body of evidence implicating patient-topatient transmission as result of unsafe injection practices and equipment. [1][2][3]8,23,24,[27][28][29][30][31] Most of the procedures implicated as possible causes of transmission in this series have been previously described including abdominal surgery, gynecological and dental procedures as well as transmission associated with glucose finger stick testing in diabetic patients. 4,8,10,16,20,21,32,33 We have not found previous reports linking HCV transmission with prostate biopsy.…”

Section: Discussionmentioning

confidence: 99%

Acute hepatitis C in Israel: A predominantly iatrogenic disease?

Lurie¹,

Landau²,

Blendis³

et al. 2007

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…Existen reportes de transmisión del VHC que no ocurrieron durante la atención sanitaria sino durante otras actividades relacionadas con la salud, como los brotes ocurridos en sujetos voluntarios de ensayos clínicos con fármacos en Canadá y en Suecia, que adquirieron la infección probablemente por inyecciones no seguras (Saginur et al, 2001;Schvarcz, Sönnerborg, Johansson, & Nyström, 1997).…”

Section: Actualización En Hepatitis Cunclassified

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C

Vélez‐Möller

2017

CTS

View full text Add to dashboard Cite

La hepatitis C, infección producida por el virus de la hepatitis C (VHC), que se transmite por sangre, es la principal causa de hepatitis crónica, cirrosis y cáncer del hígado a nivel mundial. La mortalidad, incidencia y prevalencia de las infecciones por VHC han ido en aumento, superando en muchos casos la de otras infecciones como el VIH. Más de 71 millones de personas en el mundo padecen hepatitis C crónica, pero el 80% desconoce que tiene la infección y solamente 1% ha recibido tratamiento, pese a que existen medicamentos que curan la infección en más del 90% de los casos y pueden disminuir el riesgo de las complicaciones que llevan a la muerte. En el 2016 los países miembros de la Organización Mundial de la Salud (OMS) acordaron la primera estrategia mundial del sector salud contra la hepatitis víricas 2016-2021, y para su implementación es necesario concienciar a todos los involucrados acerca de la magnitud de las hepatitis virales. Esta revisión aborda aspectos epidemiológicos, microbiológicos y clínicos con el propósito de presentar un panorama general de la situación actual de la hepatitis C a nivel mundial y nacional.

show abstract

Transmission of Hepatitis C in a Pharmacologic Study

Abstract: Infection control standards in clinical research must be maintained vigorously to prevent transmission of blood-borne pathogens such as HCV.

Cited by 9 publications

References 26 publications

Urinary Tract Infection in Male Veterans

Urinary Tract Infection in Male Veterans

Acute hepatitis C in Israel: A predominantly iatrogenic disease?

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C

Contact Info

Product

Resources

About

Transmission of Hepatitis C in a Pharmacologic Study

Abstract: Infection control standards in clinical research must be maintained vigorously to prevent transmission of blood-borne pathogens such as HCV.

Cited by 9 publications

References 26 publications

Urinary Tract Infection in Male Veterans

Urinary Tract Infection in Male Veterans

Acute hepatitis C in Israel: A predominantly iatrogenic disease?

Estado actual de la epidemiologí­a, diagnóstico, tratamiento y control de la hepatitis C

Contact Info

Product

Resources

About

Estado actual de la epidemiología, diagnóstico, tratamiento y control de la hepatitis C