Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples

Dorak, M. Tevfik; Tang, Jianming; Penman-Aguilar, Ana; Westfall, Andrew O.; Zulu, Isaac; Lobashevsky, Elena; Kancheya, Nzali; Schaen, Margaret; Allen, Susan; Kaslow, Richard A.

doi:10.1016/s0140-6736(04)16505-7

Cited by 55 publications

(48 citation statements)

References 11 publications

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“…Together, our data from Africans suggest important functional differences between B*58 and B*57 in the context of HIV/AIDS. Although the preeminence of HLA-B alleles in HIV/AIDS has been demonstrated experimentally and epidemiologically (7,14), in our Zambian cohort certain HLA-C alleles in linkage disequilibrium with their corresponding HLA-B alleles appeared to be contributing to their effect on VL. In particular, Cw*18 showed significant associations with low VL both in the presence and in the absence of B*5703, with which it is in linkage disequilibrium; conversely, VL was higher in subjects carrying B*5703 who lacked Cw*18.…”

Section: Discussioncontrasting

confidence: 51%

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Lazaryan¹,

Lobashevsky²,

Mulenga³

et al. 2006

J Virol

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Human leukocyte antigen (HLA) class I alleles can be grouped into supertypes according to their shared peptide binding properties. We examined alleles of the HLA-B58 supertype (B58s) in treatment-naïve human immunodeficiency virus type 1 (HIV-1)-seropositive Africans (423 Zambians and 202 Rwandans). HLA-B and HLA-C alleles were resolved to four digits by a combination of molecular methods, and their respective associations with outcomes of HIV-1 infection were analyzed by statistical procedures appropriate for continuous or categorical data. The effects of the individual alleles on natural HIV-1 infection were heterogeneous. In HIV-1 subtype C-infected Zambians, the mean viral load (VL) was lower among B*5703 (P ‫؍‬ 0.01) or B*5703-Cw*18 (P < 0.001) haplotype carriers and higher among B*5802 (P ‫؍‬ 0.02) or B*5802-Cw*0602 (P ‫؍‬ 0.03) carriers. The B*5801-Cw*03 haplotype showed an association with low VL (P ‫؍‬ 0.05), whereas B*5801 as a whole did not. Rwandans with HIV-1 subtype A infection showed associations of B*5703 and B*5802 with slow (P ‫؍‬ 0.06) and rapid (P ‫؍‬ 0.003) disease progression, respectively. In neither population were B*1516-

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Section: Discussioncontrasting

confidence: 51%

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Lazaryan¹,

Lobashevsky²,

Mulenga³

et al. 2006

J Virol

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“…Several studies have shown a role for HLA polymorphism in protection against HIV transmission [7][8][9][10][11][12], but its mechanism of action remains uncertain. In addition to the induction of alloimmune responses, differential HLA-restricted epitope recognition by HIV-specific CTL in recipient and donor, and HLA-KIR interactions that regulate NK cell activity have been proposed [36,37].…”

Section: Discussionmentioning

confidence: 99%

“…ESN female sex workers (FSWs) in Nairobi displayed rare HLA alleles thus being capable of manifesting alloimmune responses against the largest proportion of the population [7], and possessed specific HLA subtypes that were associated with a reduced risk of HIV infection [8]. Similarly, a decreased risk of HIV-1 transmission from mother to child and in heterosexual couples was associated with HLA class I discordance and with particular HLA alleles [9][10][11][12]. However, the alloimmune responses that are expected to result from these particular HLA polymorphisms in ESN subjects have been more difficult to detect.…”

Section: Introductionmentioning

confidence: 99%

Suppressed cellular alloimmune responses in HIV-exposed seronegative female sex workers

Jennes

Evertse

Borget

et al. 2006

Clinical and Experimental Immunology

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“…Three of these samples from our previous newborn study (origin: South Wales, UK) 42 carried B*0801-DRB1*0301, B*1302-DRB1*0701 and B*4402-DRB1*0401, respectively; two samples from bone marrow donors from the Korea Marrow Donor Program (KMDP) 112 carried B*3701-DRB1*1001; two samples from a Mongolian population study 113 carried B*5801-DRB1*0301; and two samples from a Zambian HIV-1 transmission study 114 carried B*4201-DRB1*0302. All had the same HLA and non-HLA gene polymorphisms as the corresponding CEHs.…”

Section: Other Samplesmentioning

confidence: 99%

Conserved extended haplotypes of the major histocompatibility complex: further characterization

et al. 2006

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Since the complete sequencing of a human major histocompatibility complex (MHC) haplotype, interest in non-human leucocyte antigen (HLA) genes encoded in the MHC has been growing. Non-HLA genes, which outnumber the HLA genes, may contribute to or account for HLA and disease associations. Most information on non-HLA genes has been obtained in separate studies of individual loci. To comprehensively address polymorphisms of relevant non-HLA genes in 'conserved extended haplotypes' (CEH), we investigated 101 International Histocompatibility Workshop reference cell lines and nine additional anonymous samples representing all 37 unambiguously characterized CEHs at MICA, NFKBIL1, LTA, NCR3, AIF1, HSPA1A, HSPA1B, BF, NOTCH4 and a single nucleotide polymorphism (SNP) at HLA-DQA1 as well as MICA, NOTCH4, HSPA1B and all five tumour necrosis factor short tandem repeat (STR) polymorphisms. This work (1) provides an extensive catalogue of MHC polymorphisms in all CEHs, (2) unravels interrelationships between HLA and non-HLA haplotypical lineages, (3) resolves reported typing ambiguities and (4) describes haplospecific markers for a number of CEHs. Analysis also identified a DQA1 SNP and segments containing MHC class III polymorphisms that corresponded with class II (DRB3 and DRB4) lineages. These results portray the MHC where lineages containing non-HLA and HLA variants in linkage disequilibrium may operate in concert and can guide more thorough design and interpretation of HLA-disease relationships.

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Transmission of HIV-1 and HLA-B allele-sharing within serodiscordant heterosexual Zambian couples

Cited by 55 publications

References 11 publications

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Human Leukocyte Antigen B58 Supertype and Human Immunodeficiency Virus Type 1 Infection in Native Africans

Suppressed cellular alloimmune responses in HIV-exposed seronegative female sex workers

Conserved extended haplotypes of the major histocompatibility complex: further characterization

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