Transmission of human mitochondrial DNA along the paternal lineage in transmitochondrial mice

Kidgotko, O. V.; Kustova, Maria Ye.; Sokolova, Vassilina A.; Bass, Mikhail G.; Vasilyev, V. B.

doi:10.1016/j.mito.2013.03.004

Cited by 16 publications

(4 citation statements)

References 38 publications

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“…The possibility of paternal inheritance of mtDNA has been reported previously in mice, including across multiple generations. 3,4 Tissue-specific inheritance of paternal mtDNA in humans has also been reported in a single individual with mitochondrial myopathy whose skeletal muscle had a de novo homoplasmic 2-bp deletion in the MT-ND2 gene on the paternal mtDNA haplotype, while only maternal mtDNA was detected in other tissues tested. 5 The recent finding by Luo et al 2 prompts reconsideration of whether paternal inheritance may be more common in humans than previously considered.…”

Section: Introductionmentioning

confidence: 84%

Biparental inheritance of mitochondrial DNA in humans is not a common phenomenon

Rius

Cowley

Riley

et al. 2019

Genetics in Medicine

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Section: Introductionmentioning

confidence: 84%

Biparental inheritance of mitochondrial DNA in humans is not a common phenomenon

Rius

Cowley

Riley

et al. 2019

Genetics in Medicine

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“…Despite the numerous pathways that either eliminate paternal mitochondria or prevent their replication, paternal mitochondrial leakage is still detected in many species such as fish ( Peng et al 2018 ), insects ( Kondo et al 1990 ; Ma et al 2014 ; Polovina et al 2020 ), mice ( Gyllensten et al 1991 ; Kidgotko et al 2013 ), sheep ( Zhao et al 2004 ), and even human beings ( Luo et al 2018 ). One study found that paternal mitochondria in mice are eliminated in intraspecific crosses but not in interspecific crosses ( Kaneda et al 1995 ).…”

Section: Introductionmentioning

confidence: 99%

“…It is also important to discern whether the preserved paternal mitochondria are functional, as there would be little apparent evolutionary benefit from retaining nonfunctional mitochondria. Previously, there have been a few studies showing paternal mitochondrial leakage in fruit flies and mice ( Kidgotko et al 2013 ; Wolff et al 2013 ; Polovina et al 2020 ), but no studies showing the functional state of the retained paternal mitochondria.…”

Section: Introductionmentioning

confidence: 99%

Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila

Cao,

Luo,

Chen

et al. 2024

Genetics

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The maternal inheritance of mitochondria is a widely accepted paradigm, and mechanisms that prevent paternal mitochondria transmission to offspring during spermatogenesis and post-fertilization have been described. Although certain species do retain paternal mitochondria, the factors affecting paternal mitochondria inheritance in these cases are unclear. More importantly, the evolutionary benefit of retaining paternal mitochondria and their ultimate fate are unknown. Here we show that transplanted exogenous paternal D. yakuba mitochondria can be transmitted to offspring when maternal mitochondria are dysfunctional in D. melanogaster. Furthermore, we show that the preserved paternal mitochondria are functional, and can be stably inherited, such that the proportion of paternal mitochondria increases gradually in subsequent generations. Our work has important implications that paternal mitochondria inheritance should not be overlooked as a genetic phenomenon in evolution, especially when paternal mitochondria are of significant differences from the maternal mitochondria or the maternal mitochondria are functionally abnormal. Our results improve the understanding of mitochondrial inheritance and provide a new model system for its study.

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“…Uniparental inheritance was first shown in rats [5] and mice [6] and then confirmed in humans [7]. Although several studies debate the biparental mtDNA inheritance [8][9][10][11], such cases seem to be very rare, and their mechanisms remain largely unknown. Secondly, the mitochondrial genome exists in multiple copies.…”

Section: Introductionmentioning

confidence: 99%

Natural and Artificial Mechanisms of Mitochondrial Genome Elimination

Zakirova

Muzyka

Мазунин

et al. 2021

Life

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The generally accepted theory of the genetic drift of mitochondrial alleles during mammalian ontogenesis is based on the presence of a selective bottleneck in the female germline. However, there is a variety of different theories on the pathways of genetic regulation of mitochondrial DNA (mtDNA) dynamics in oogenesis and adult somatic cells. The current review summarizes present knowledge on the natural mechanisms of mitochondrial genome elimination during mammalian development. We also discuss the variety of existing and developing methodologies for artificial manipulation of the mtDNA heteroplasmy level. Understanding of the basics of mtDNA dynamics will shed the light on the pathogenesis and potential therapies of human diseases associated with mitochondrial dysfunction.

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Transmission of human mitochondrial DNA along the paternal lineage in transmitochondrial mice

Cited by 16 publications

References 38 publications

Biparental inheritance of mitochondrial DNA in humans is not a common phenomenon

Biparental inheritance of mitochondrial DNA in humans is not a common phenomenon

Maternal mitochondrial function affects paternal mitochondrial inheritance in Drosophila

Natural and Artificial Mechanisms of Mitochondrial Genome Elimination

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