Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Rosso, Fernando; Rojas, Olga L.; Gil, Cindy Carolina Suarez; Vargas, Jaime Alberto López; Mesa, Juan E.; Carrillo, Diana Cristina Henao; Ramirez, Liliana Meza; Rusca, Luis Armando Caicedo

doi:10.1111/tid.13660

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…If this donor had presented in Florida, there would be a concern for Malaria, given the cases of local transmission identified in 2023. 7,8 Without the demographic information provided, the differential broadens further to include other parasitic infections and viral encephalitis such as West Nile Virus, 9 many of which have high penetrance to organ recipients. This case highlights the potential for transmissibility of infection within a newly transplanted organ.…”

Section: Casesmentioning

confidence: 99%

“…Keeping up to date on outbreaks is important given the concern for transmission of diseases from donor to recipients. If this donor had presented in Florida, there would be a concern for Malaria, given the cases of local transmission identified in 2023 7,8 . Without the demographic information provided, the differential broadens further to include other parasitic infections and viral encephalitis such as West Nile Virus, 9 many of which have high penetrance to organ recipients.…”

Section: Introductionmentioning

confidence: 99%

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“They paged me what?”: A transplant infectious disease guide to donor calls

Gorsline,

Tyler,

Sigler

et al. 2023

Transplant Infectious Dis

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Donor‐derived infections in solid organ transplantation can be prevented by risk stratification of donors based on available information, and inquiries surrounding possible or diagnosed infection are common questions posed to transplant infectious disease subspecialists. This article outlines the five key steps in addressing a donor call from a transplant team in a systematic approach, focusing on donor and recipient‐specific factors, transmissibility and treatment of possible infections, and the likelihood of a patient's future organ offers and mortality remaining on the waitlist. These principles are then applied to five donor call cases, in which we review the key takeaway points and supporting literature. These cases can be used as a resource for teaching with trainees. image

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Section: Casesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“They paged me what?”: A transplant infectious disease guide to donor calls

Gorsline,

Tyler,

Sigler

et al. 2023

Transplant Infectious Dis

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“…Rarely, malaria transmission via organ transplantation has been reported. In a recent case series, authors reported P. vivax infections in three patients who received a liver, kidney, or a heart transplant from a single donor who was later found to have had malaria prior to his death [15 ▪ ]. Their review suggested that the laboratory and clinical features of P. vivax infection in transplant recipients could be severe and included thrombocytopenia, hemolytic anemia, fever and graft dysfunction due to hemodynamic changes.…”

Section: New Insights Into Pathogenesismentioning

confidence: 99%

Update on pathogenesis, management, and control of Plasmodium vivax

Khan

Daily

2022

Current Opinion in Infectious Diseases

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Purpose of reviewThis is a review of Plasmodium vivax epidemiology, pathogenesis, disease presentation, treatment and innovations in control and elimination. Here, we examine the recent literature and summarize new advances and ongoing challenges in the management of P. vivax. Recent findingsP. vivax has a complex life cycle in the human host which impacts disease severity and treatment regimens. There is increasing data for the presence of cryptic reservoirs in the spleen and bone marrow which may contribute to chronic vivax infections and possibly disease severity. Methods to map the geospatial epidemiology of P. vivax chloroquine resistance are advancing, and they will inform local treatment guidelines. P. vivax treatment requires an 8-aminoquinoline to eradicate the dormant liver stage. Evidence suggests that higher doses of 8-aminoquinolines may be needed for radical cure of tropical frequentrelapsing strains. Summary P. vivax is a significant global health problem. There have been recent developments in understanding the complexity of P. vivax biology and optimization of antimalarial therapy. Studies toward the development of best practices for P. vivax control and elimination programs are ongoing. Keywords 8-aminoquinoline, cryptic infection, glucose-6-phosphate dehydrogenase deficiency, P. vivax drug resistance, P. vivax prevention, P. vivax treatment, Plasmodium vivax, Plasmodium vivax circumsporozoite protein (PvCSP) vaccine development, radical cure P. vivax was estimated to cause 4.5 million (2%) of the 241 million cases of malaria in 2020 [2]. P. vivax is prevalent in the Middle East, Asia, the Western Pacific and Central and South America as well as in parts of Africa [1]. P. vivax accounted for 68.3% of malaria cases in the Americas, 36.3% of cases in Southeast Asia, 30.1% of cases in the Western Pacific, 18.1% of cases in the Eastern Mediterranean and 0.3% of cases in Africa in 2020 [2].P. vivax, like other Plasmodium species, is acquired from the bite of an infected female Anopheles mosquito. Sporozoites enter the bloodstream

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“…4 However, it can also be transmitted by blood transfusion, transplacental, organ transplantation, and through the use of improper syringes. 5 Regarding transfusion-transmitted malaria (TTM), in Brazil, a single case was reported in São Paulo in 2011. 6 Nevertheless, there is a lack of data about the prevalence of asymptomatic infected blood donors in such urban areas across Brazil.…”

Section: Introductionmentioning

confidence: 99%

“…The parasite is spread by the bite of female Anopheles mosquitoes 4 . However, it can also be transmitted by blood transfusion, transplacental, organ transplantation, and through the use of improper syringes 5 …”

Section: Introductionmentioning

confidence: 99%

Detection of Plasmodium spp. in asymptomatic blood donors by the new Brazilian NAT PLUS HIV/HBV/HCV/Malaria Bio‐Manguinhos kit

Costa,

Rocha,

Lopes

et al. 2024

Transfusion

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BackgroundTransfusion‐transmitted malaria (TTM) is a public health problem in endemic and nonendemic areas. The Brazilian Ministry of Health (MH) requested the development of a nucleic acid amplification test (NAT) for the detection of Plasmodium spp. in public blood centers to increase blood safety.Study Design and MethodsThe new Brazilian NAT kit named NAT PLUS HIV/HBV/HCV/Malaria Bio‐Manguinhos was first implemented in HEMORIO, a public blood center in the city of Rio de Janeiro. Since October 1, 2022, this blood center has been testing all its blood donations for malaria in a pool of six plasma samples to detect Plasmodium spp. by real‐time polymerase chain reaction (PCR).ResultsSince the implementation of the NAT PLUS platform until February 2023, HEMORIO has successfully received and tested 200,277 donations. The platform detected two asymptomatic donors in the city of Rio de Janeiro, which is a nonendemic region for malaria. Our analyses suggested a malaria from the Amazon region caused by Plasmodium vivax, in the first case, while an autochthonous transmission case by Plasmodium malariae was identified in the rural area of Rio de Janeiro state.DiscussionThe NAT PLUS platform detects Plasmodium spp. in plasma samples with sensitivity capable of detecting subpatent infections. This is the first time worldwide that a group developed and implemented molecular diagnosis for Plasmodium spp. to be used by public blood centers to avoid TTM.

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Transmission of malaria from donors to solid organ transplant recipients: A case report and literature review

Cited by 9 publications

References 27 publications

“They paged me what?”: A transplant infectious disease guide to donor calls

“They paged me what?”: A transplant infectious disease guide to donor calls

Update on pathogenesis, management, and control of Plasmodium vivax

Detection of Plasmodium spp. in asymptomatic blood donors by the new Brazilian NAT PLUS HIV/HBV/HCV/Malaria Bio‐Manguinhos kit

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