Transmission of Maternal Antibodies to Sendai Virus in Mice and its Significance in Enzootic Infection

Abstract

SUMMARYMaternal antibodies to Sendai virus appeared to be transferred to newborn mice to a greater extent via colostrum and gastro-intestinal tract than via the placenta. Serum antibody reached a maximum within a week of birth and remained high for a few weeks before decreasing gradually. The immunoelectrophoretic analysis of serum globulins of suckling mice demonstrated IgG1 and IgG~ but no IgA, and suggested a selective transport of maternal globulins through the gastrointestinal epithelium of suckling mice. The maternal antibody effectively protected one-day-old newborn mice against intranasal challenge by a lethal dose of Sendal virus, but was less effective against the contact infection of 3-week-old mice. Thus, passive immunity appeared to be brief. Enzootic infections with Sendai virus are discussed on the basis of these experiments.

The role of colostrum and milk in protection of the neonatal mouse against peripheral infection with Ross River virus

“…Serum was taken from the mothers and neonates 9 days after birth b Sera were fractionated on a Sepharose CL-4B-protein A column using a linear pl-[ gradient Non-fraetionated 640 1280 < 10 < 10 serum Serum pools were fraetionated on a Sepharose CL-48 protein A column b Neonates from uninfected mothers were fostered onto post-parturient immune mothers previously infected at gestation day 11 with 2600 P F U of Ross River virus. This agrees with FAHEY and BA~TI~ (2) and IIDA et al (6), and suggests that the major role of eolostral IgM and IgA is in defense of the neonate against enteric pathogens. Serum was taken from the mothers and neonates 9 days after birth c ReeiproeM of the H I titre presented (Table 1) suggests t h a t t h e p r o t e c t i o n was n o t d u e to a n a c t i v e i m m u n e response, a n d t h a t t h e a n t i -R R V I g G (Table 2) was therefore m a t e r n a l in origin.…”

Protection of mice against virulent virus infection by a temperature-sensitive mutant derived from an HVJ (Sendai virus) carrier culture

“…It might possibly occur that antibody formed in response to contact infection in the mothers would be transferred to newborn mice via colostrum. However, it should take too long time for the mother to form antibodies and to secrete these into milk to allow maternal antibodies to interfere in this system (6,18). In a i0 days' interval between primary infection and challenge the mother showed no HI antibody response within an observation period of 15 days.…”

Comparison of protective effects of serum antibody on respiratory and systemic infection of Sendai virus in mice

“…For the viruses which usually involve the infection of the respiratory tract, such as influenza and parainfluenza viruses, local immunity of the IgA class has been considered a most important factor [3, 4, 13-16, 20, 25]. Serum antibody has been also postulated to play an important role in the protection against the infections [4,9,23,[31][32][33], and the findings are contradictory whether serum antibody is less effective for the protection against infections on the surface of the respiratory tract [1 t, 12, 14, 19, 21, 24, 35]. Sendai virus, a parainfluenza virus type 1 that is exclusively pneumotropic in mice, has been studied widely as a model for respiratory viral infections.…”