Transmission of maternal immunity

Mason, J. H.; Dalling, T.; Gordon, W. S.

doi:10.1002/path.1700330324

Cited by 86 publications

(29 citation statements)

References 5 publications

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“…It has been suggested that this period may be curtailed by the onset of protein digestion (Mason, Dalling & Gordon, 1930;Hill, 1956;Deutsch & Smith, 1957;Chamberlain, Perry & Jones, 1965), but it has been demonstrated that the absorption of polyvinyl pyrrolidone by the young pig (Lecce, Matrone & Morgan, 1961;Hardy, 1965Hardy, , 1969b, by the calf (Hardy, 1969a) and by the young rat (Clarke & Hardy,1969) ceases at the same time as the absorption of intact protein. Thus, since PVP is not broken down within the gut, protein digestion cannot be the factor which limits the absorption of antibodies.…”

Section: Discussionmentioning

confidence: 99%

The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig

Hardy¹

1969

The Journal of Physiology

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SUMMARY1. The intestinal absorption of [1311]porcine and bovine serum yglobulin after oral administration has been investigated in conscious pigs less than 20 hr old. Absorption was measured by the concentration of 1311 in venous blood during the 6 hr after feeding and also by the distribution of 131I between homogenates of the alimentary tract and the rest of the animal at the end of the experiment.2. The concentration of 131I in the blood was always low after feeding [131I]y-globulin, although a large proportion of the isotope fed was found to have left the alimentary tract. This indicated that much of the [1311]-y-globulin had been hydrolysed into fragments of low mol.wt. which were not retained in the plasma. There were no significant differences between results obtained with homologous and heterologous y-globulin.3. Examination by gel-filtration confirmed that, after feeding [131I]_ serum y-globulin, much of the 131I in the plasma was associated with material of mol.wt. less than 12,400 and demonstrated that the breakdown of bovine y-globulin was comparable with that of homologous y-globulin. with that from a chloride solution with a similar Na+ and K+ concentration showed that, although the blood concentration remained low, colostrum reduced the hydrolysis of the labelled protein.5. This effect of colostrum could be simulated by the addition to the chloride solution of either the synthetic trypsin inhibitor Trasylol or a higher concentration of unlabelled protein.

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Section: Discussionmentioning

confidence: 99%

The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig

Hardy¹

1969

The Journal of Physiology

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“…In the pig, in the horse, and in ungulates, passive immunity is transmitted principally by means of intestinal absorption of antibodies from colostrum or milk (4, 10, 37,68) . At birth the pig possesses only traces of antibodies (44,46,60), the main source of which is colostrum (20,47,48,53) .…”

Section: Introductionmentioning

confidence: 99%

Early Stages of Intestinal Absorption of Specific Antibodies in the Newborn

Kraehenbuhl

Campiche

1969

The Journal of Cell Biology

147

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In mammals, passive immunity is transferred from mother to offspring by transplacental passage or by intestinal absorption. The rabbit receives antibodies exclusively across the placenta, whereas intestinal absorption is the principal source of antibodies for the new-born pig. In the rat, passive immunity is transferred by both pathways. The role of the jejunal absorptive cells was investigated in these three species, by the use of specific immune globulins as tracers of protein absorption. Rabbit anti-peroxidase and anti-ferritin antibodies were injected into the jejunum of newborn pigs, rats, and rabbits, and absorption was studied over the first 2 hr. The specific antibodies were detected in glutaraldehyde-fixed tissues after in vitro treatment with the antigens, and in sera by immunological methods. Intact antibodies are transferred into the circulation of the pig and the rat, but not into that of the rabbit. In the three species, the jejunal absorptive cells take up antibodies by endocytosis. In the pig, the antibodies are transported across the epithelium in vacuoles. In the rabbit, the endocytosis of antibodies triggers a lysosomal response and all absorbed antibodies are trapped in lysosomes. In the rat, both situations are found; there is no evidence of transfer of antibody fragments into the circulation.

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“…Thus, it has been demonstrated that the placentas of sheep, goats, pigs, horses, cattle, and dogs are impermeable to the passage of antibodies, whereas those of human beings, rabbits, and guinea pigs are readily permeable (8,12). It has been suggested by Kuttner and Rather (13) that the nature of the anatomical barrier, particularly the number of layers of tissue that are interposed between the maternal and fetal circulations, plays an important part in this process.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that in many animal species maternal antibodies are present in the milk at the time of birth and during the first few days of the postpartum period, and that in the dog, cow, horse, and sheep significant quantities of a variety of different antibodies are transferred to the newborn during the 1st day of life v/a the mother's milk (8). A similar situation has been found to obtain in the rabbit with respect to the antibodies to the G-g factors.…”

Section: Isoantibodies To Tke G-g Factors In M I L Kmentioning

confidence: 99%

Experimental Erythroblastosis Fetalis in Rabbits

Kellner

Hedal

1953

Journal of Experimental Medicine

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Female rabbits became immunized during pregnancy to the rabbit blood group factors G or g in five out of ten instances in which the red cells of the fetuses carried one of the factors absent in the mother. Antibodies so produced were of low titer and disappeared in all cases within 6 weeks after the birth of the litter. Repeated pregnancies did not result in additive increases in titer. Antibodies to the G-g factors, whether produced by the injection of red cells or by pregnancy, crossed the placenta readily from mother to fetus and were found at birth (and prior to nursing) associated with the red cells and in the serum of the fetuses. The rabbit placenta appeared to be equally permeable to the agglutinating and coating antibodies. The implications of these findings and their relation to the pathogenesis of erythroblastosis fetalis are briefly touched upon.

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Transmission of maternal immunity

Cited by 86 publications

References 5 publications

The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig

The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig

Early Stages of Intestinal Absorption of Specific Antibodies in the Newborn

Experimental Erythroblastosis Fetalis in Rabbits

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Transmission of maternal immunity

Cited by 86 publications

References 5 publications

The break‐down of [131I]γ‐globulin in the digestive tract of the new‐born pig

The break‐down of [131I]γ‐globulin in the digestive tract of the new‐born pig

Early Stages of Intestinal Absorption of Specific Antibodies in the Newborn

Experimental Erythroblastosis Fetalis in Rabbits

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The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig

The break‐down of [¹³¹I]γ‐globulin in the digestive tract of the new‐born pig