Transmission of Pseudomonas cepacia by social contact in cystic fibrosis

Smyth, Alan; Heaf, D P; Corkill, J. E.; Hart, Tony; Sisson, Penny; Freeman, R.

doi:10.1016/0140-6736(93)92847-m

Cited by 9 publications

(4 citation statements)

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“…A previous French epidemiological survey showed that the prevalence rates of B. cepacia colonization varied from 0 to 40% within CF centers (31). These data strongly suggested the possibility of epidemic situations in some centers, as previously described in North American (21) and British (12,24,33,34) CF centers. The present DNA-based study clearly demonstrates the occurrence of cross-contamination in 7 of the 13 French CF centers investigated.…”

Section: Discussionsupporting

confidence: 66%

“…Pulmonary colonization with Burkholderia cepacia (formerly Pseudomonas cepacia), a bacterium which was first described as a phytopathogen, is associated with poor clinical prognosis in some patients with cystic fibrosis (CF) (14,19,38). Several outbreaks have been reported in North America (15,21) and Great Britain (12,24,26,33,34). Person-to-person transmission was corroborated by genomic analysis of isolates in these outbreaks.…”

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confidence: 99%

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Genotypic analysis of Burkholderia cepacia isolates from 13 French cystic fibrosis centers

et al. 1997

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Burkholderia cepacia has been involved in outbreaks of pulmonary infection among patients with cystic fibrosis (CF), and the spread of a highly transmissible clone has been reported throughout the United Kingdom and Canada. These data prompted a DNA-based typing study of the strains recovered in French CF centers. Ninety-five isolates recovered from 71 patients attending 13 CF centers in 9 regions of France were characterized by randomly amplified polymorphic DNA (RAPD) analysis and pulsed-field gel electrophoresis (PFGE). Twenty-one genotypes were identified among the 95 isolates, and the results of RAPD and PFGE were concordant for 89 isolates (94%). Cross-colonization was demonstrated in 7 of the 13 CF centers. The investigation of serial isolates showed that most chronically colonized patients harbored a single B. cepacia strain. A geographically clustered distribution of B. cepacia genotypes was observed, except for one genotype, which was detected in four regions but was proven to be different from the genotype of the British-Canadian highly transmissible strain. The present study confirms the ability of B. cepacia to spread among CF communities in France and the importance of epidemiological surveys in the institution of prevention policies.

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Section: Discussionsupporting

confidence: 66%

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confidence: 99%

Genotypic analysis of Burkholderia cepacia isolates from 13 French cystic fibrosis centers

et al. 1997

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“…Smyth et al [83] noted that on cessation of Adult CF Association meetings in the local area, no new isolates of BCC occurred.…”

Section: Social Eventsmentioning

confidence: 99%

Infection prevention and control in cystic fibrosis: a systematic review of interventions

Rowbotham

Palser

Smith

et al. 2019

Expert Review of Respiratory Medicine

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Introduction: Cystic fibrosis is a life-limiting genetic condition characterized by recurrent pulmonary infection. Acquisition of infection can occur from environmental reservoirs, person-to-person transmission and from the healthcare environment. Primary prevention of infections through infection prevention and control measures is an important strategy in cystic fibrosis care. Areas covered: Here we present a systematic review of the evidence base around infection prevention and control in cystic fibrosis. We found 36 studies and 7 guidelines that met our inclusion criteria. Strategies covered include cohort segregation, individual segregation, hand hygiene, facemasks, combination strategies, equipment strategies, and adherence. Quality of evidence overall was deemed low or very low. Most guideline recommendations have little or no evidence to support them. Expert opinion: Although low quality, there is an abundance of evidence suggesting segregation is beneficial in reducing pathogen spread. Undertaking high-quality studies may, therefore, be ethically challenging. Large-scale registry studies may provide a better strategy for answering questions on the efficacy of infection control policy. With the rise of antibiotic resistance, effective eradication of cystic fibrosis pathogens is becoming more difficult so primary prevention through infection control will become increasingly important over the coming years. ARTICLE HISTORY

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“…Person to person spread has been proposed for multi-drug resistant P. aeruginosa, 4 MRSA, 5 B. cepacia complex 6 and M. abscessus. 7 Acquisition of both P. aeruginosa 8 and MRSA 5 from the hospital environment has been suggested. P. aeruginosa is present in the homes of CF patients with a new pulmonary infection but it has not been established whether the patient contaminates their environment or vice versa.…”

Section: Introductionmentioning

confidence: 99%

Infection prevention and control in cystic fibrosis: One size fits all The argument against

Smyth

Smith

Rowbotham

2020

Paediatric Respiratory Reviews

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Transmission of Pseudomonas cepacia by social contact in cystic fibrosis

Cited by 9 publications

References 1 publication

Genotypic analysis of Burkholderia cepacia isolates from 13 French cystic fibrosis centers

Genotypic analysis of Burkholderia cepacia isolates from 13 French cystic fibrosis centers

Infection prevention and control in cystic fibrosis: a systematic review of interventions

Infection prevention and control in cystic fibrosis: One size fits all The argument against

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