Transmission of Streptococcus pneumoniae in an urban slum community

Reis, Joice Neves; Palma, Tania; Ribeiro, Guilherme S.; Pinheiro, Ricardo M.; Ribeiro, Cássio T.; Cordeiro, Soraia Machado; Filho, Hermes Pedreira da Silva; Moschioni, Monica; Thompson, Terry A.; Spratt, Brian G.; Riley, Lee W.; Barocchi, Michèle A.; Reis, Mitermayer Galvão dos; Ko, Albert I.

doi:10.1016/j.jinf.2008.06.017

“…13,19,25 described by other studies, as well as the association between penicillin resistance and sulfamethoxazole-trimethoprim resistance. 13,19,26 With regard to the resistance rates of 8.7 and 6.5% for erythromycin and tetracycline found in our study, similar results were found with strains isolated in different Brazilian studies, with results ranging from 1 to 10% for erythromycin and from 12.6 to 24% for tetracycline. 13,19,26 In Europe, these rates are higher, and they may be higher than 50%…”

Section: Antimicrobial Agents Resistant Strains N (%)supporting

confidence: 90%

Alta prevalência de crianças portadoras de Streptococcus pneumoniae resistentes à penicilina em creches públicas

Velásquez¹,

Parussolo²,

Cardoso³

et al. 2009

J. Pediatr. (Rio J.)

0

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Objectives: To investigate the prevalence of Streptococcus pneumoniae (pneumococci) in the nasopharynx of healthy children enrolled in public day-care centers of the municipality of Umuarama, state of Paraná, Brazil. The susceptibility of the pneumococcal strains to antimicrobial agents was also studied.Methods: Nasopharyngeal specimens from 212 children were collected from April to October 2008. After the specimens were seeded onto blood agar and incubated at 37 °C for 24-48 hours, the colonies suspected of belonging to S. pneumoniae were identified using α-hemolysis, optochin sensitivity, and bile solubility test. Penicillin susceptibility was investigated using the disk diffusion and dilution tests. Susceptibility to the other antimicrobial agents indicated for the treatment of pneumococcal infections was investigated using the disk diffusion test. Results:The prevalence of nasopharyngeal pneumococci was 43.4% (92/212), with higher rates in children between 2 and 5 years old (p = 0.0005). There was no significant difference between sexes. Intermediate and full resistance to penicillin were found in 34.8 (32/92) and 22.8% (21/92) isolates, respectively. Sixty-seven strains (72.8%) were resistant to sulfamethoxazole-trimethoprim, eight (8.7%) were resistant to erythromycin, and six (6.5%) to tetracycline. One strain was resistant to clindamycin (1.1%) and another was resistant to chloramphenicol (1.1%). All strains were sensitive to levofloxacin, ofloxacin, rifampicin, telithromycin, linezolid, and vancomycin. Nine strains were considered multiresistant because they were resistant to three or more classes of antimicrobial agents. Conclusions:The present study detected a high prevalence of healthy children colonized with penicillin-resistant S. pneumoniae strains who may be important reservoirs of this pathogen in the community.J Pediatr (Rio J). 2009;85(6):516-522: Streptococcus pneumoniae, nasopharynx, healthy carriers, penicillin resistance.

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“…O alto índice de resistência ao sulfametoxazol-trimetoprim encontrado em nosso estudo (72,8%) é semelhante ao descrito em outros trabalhos, assim como a associação entre resistência à penicilina e sulfametoxazol-trimetoprim 13,19,26 .…”

Section: Tabela 3 -Perfil Da Multirresistência De Nove Amostras De Stunclassified

“…Em relação às taxas de resistência de 8,7 e 6,5% para eritromicina e tetraciclina encontradas em nosso estudo, resultados semelhantes foram obtidos com amostras isoladas em diferentes estudos brasileiros, com resultados variando de 1 a 10% para eritromicina e de 12,6 a 24% para tetraciclina 13,19,26 . Na Europa, estes índices são mais elevados, podendo ser superiores a 50% para os macrolídeos e superiores a 80% para a tetraciclina 27,28 .…”

Section: Tabela 3 -Perfil Da Multirresistência De Nove Amostras De Stunclassified

High prevalence of children colonized with penicillin-resistant <i>Streptococcus pneumoniae</i> in public day-care centers

Velásquez

¹

,

Parussolo

²

,

Cardoso

³

et al. 2009

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Objectives: To investigate the prevalence of Streptococcus pneumoniae (pneumococci) in the nasopharynx of healthy children enrolled in public day-care centers of the municipality of Umuarama, state of Paraná, Brazil. The susceptibility of the pneumococcal strains to antimicrobial agents was also studied.Methods: Nasopharyngeal specimens from 212 children were collected from April to October 2008. After the specimens were seeded in blood agar and incubated at 37 °C for 24-48 hours, the colonies suspected of belonging to S. pneumoniae were identified using α-hemolysis, optochin sensitivity, and bile solubility test. Penicillin susceptibility was investigated using the disk diffusion and dilution tests. Susceptibility to the other antimicrobial agents indicated for the treatment of pneumococcal infections was investigated using the disk diffusion test. Results:The prevalence of nasopharyngeal pneumococci was 43.4% (92/212), with higher rates in children between 2 and 5 years old (p = 0.0005). There was no significant difference between sexes. Intermediate and full resistance to penicillin were found in 34.8 (32/92) and 22.8% (21/92) isolates, respectively. Sixty-seven strains (72.8%) were resistant to sulfamethoxazole-trimethoprim, eight (8.7%) were resistant to erythromycin, and six (6.5%) to tetracycline. One strain was resistant to clindamycin (1.1%) and another was resistant to chloramphenicol (1.1%). All strains were sensitive to levofloxacin, ofloxacin, rifampicin, telithromycin, linezolid, and vancomycin. Nine strains were considered multiresistant because they were resistant to three or more classes of antimicrobial agents. Conclusions:The present study detected a high prevalence of healthy children colonized with penicillin-resistant S. pneumoniae strains who may be important reservoirs of this pathogen in the community.J Pediatr (Rio J). 2009;85(6): 516-522: Streptococcus pneumoniae, nasopharynx, healthy carriers, penicillin resistance. ResumoObjetivos: Investigar a prevalência de Streptococcus pneumoniae (pneumococos) na nasofaringe de crianças sadias atendidas em creches municipais da cidade de Umuarama (PR). Avaliar a susceptibilidade aos antimicrobianos dos pneumococos isolados.Métodos: Secreção da nasofaringe de 212 crianças foi coletada no período de abril a outubro de 2008. Após semeadura dos espécimes em ágar sangue e incubação a 37 °C por 24-48 horas, as colônias suspeitas de pertencerem a S. pneumoniae foram identificadas pela α-hemóli-se, sensibilidade à optoquina e bile solubilidade. A susceptibilidade à penicilina foi investigada pelos testes de disco-difusão e de diluição. A susceptibilidade aos demais antimicrobianos indicados no tratamento das infecções pneumocócicas foi realizada por disco-difusão.Resultados: A prevalência de pneumococos na nasofaringe foi de 43,4% (92/212), sendo maior em crianças com idade entre 2 e 5 anos (p = 0,0005). Não houve diferença significativa entre os sexos. Resistência intermediária e resistência plena à penicilina foram encontradas respectivamente e...

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“…En el caso de este estudio, se reporta una mayor percepción de inseguridad en barrios de viviendas sociales, en comparación con campamentos, lo cual indica un deterioro +Model RCHIPE-35; No. of Pages 9 8 S. Burgos et al en el ambiente social que podría vincularse a eventos en la esfera psicosocial de los niños y niñas y sus familias y a diferenciales de morbilidad, que requerirían ser evaluados en un estudio con mayor capacidad generativa de evidencia. En términos metodológicos es importante destacar que existen limitaciones a considerar en la interpretación de los resultados.…”

Section: Discussionunclassified

Salud ambiental infantil en el contexto de la reubicación de familias de campamentos a viviendas sociales

Burgos

¹

,

Sigala

²

,

Argueta

³

et al. 2015

Revista Chilena de Pediatría

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Transmission of Streptococcus pneumoniae in an urban slum community

Abstract: Background-Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.

Cited by 33 publications

References 34 publications

Alta prevalência de crianças portadoras de Streptococcus pneumoniae resistentes à penicilina em creches públicas

Alta prevalência de crianças portadoras de Streptococcus pneumoniae resistentes à penicilina em creches públicas

High prevalence of children colonized with penicillin-resistant <i>Streptococcus pneumoniae</i> in public day-care centers

Salud ambiental infantil en el contexto de la reubicación de familias de campamentos a viviendas sociales

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Transmission of Streptococcus pneumoniae in an urban slum community

Abstract: Background-Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries.

Cited by 33 publications

References 34 publications

Alta prevalência de crianças portadoras de Streptococcus pneumoniae resistentes à penicilina em creches públicas

Alta prevalência de crianças portadoras de Streptococcus pneumoniae resistentes à penicilina em creches públicas

High prevalence of children colonized with penicillin-resistant &lt;i&gt;Streptococcus pneumoniae&lt;/i&gt; in public day-care centers

Salud ambiental infantil en el contexto de la reubicación de familias de campamentos a viviendas sociales

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High prevalence of children colonized with penicillin-resistant <i>Streptococcus pneumoniae</i> in public day-care centers